scholarly journals N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26235-26246 ◽  
Author(s):  
Carmela Mazzoccoli ◽  
Vitalba Ruggieri ◽  
Tiziana Tataranni ◽  
Francesca Agriesti ◽  
Ilaria Laurenzana ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Chemotherapeutic Agents ◽  
Neuroblastoma Cell Line

scholarly journals Sulfatide-Rich Liposome Uptake by a Human-Derived Neuroblastoma Cell Line

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1615
Author(s):  
Daniel Arroyo-Ariza ◽  
Elizabeth Suesca ◽  
Chad Leidy ◽  
John M. Gonzalez
Keyword(s):  
Cell Membrane ◽  
Cell Line ◽  
Targeted Delivery ◽  
Neuroblastoma Cell ◽  
Density Lipoprotein ◽  
Chemotherapeutic Agents ◽  
Neuroblastoma Cell Line ◽  
Endocytic Pathway ◽  
Astrocytoma Cell Line ◽  
Astrocytoma Cell

Liposomes are bilayer membrane vesicles that can serve as vehicles for drug delivery. They are a good alternative to free drug administration that provides cell-targeted delivery into tumors, limiting the systemic toxicity of chemotherapeutic agents. Previous results from our group showed that an astrocytoma cell line exhibits selective uptake of sulfatide-rich (SCB) liposomes, mediated by the low-density lipoprotein receptor (LDL-R). The goal of this study was to assess the uptake of liposomes in a neuroblastoma cell line. For this purpose, we used two types of liposomes, one representing a regular cell membrane (DOPC) and another rich in myelin components (SCB). An astrocytoma cell line was used as a control. Characterization of liposome uptake and distribution was conducted by flow cytometry and fluorescence microscopy. Similar levels of LDL-R expression were found in both cell lines. The uptake of SCB liposomes was higher than that of DOPC liposomes. No alterations in cell viability were found. SCB liposomes were located near the cell membrane and did not colocalize within the acidic cellular compartments. Two endocytic pathway inhibitors did not affect the liposome uptake. Neuroblastoma cells exhibited a similar uptake of SCB liposomes as astrocytoma cells; however, the pathway involved appeared to be different than the hypothesized pathway of LDL-R clathrin-mediated endocytosis.

scholarly journals HLXB9 Gene Expression, and Nuclear Location during In Vitro Neuronal Differentiation in the SK-N-BE Neuroblastoma Cell Line

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105481 ◽  
Author(s):  
Claudia Giovanna Leotta ◽  
Concetta Federico ◽  
Maria Violetta Brundo ◽  
Sabrina Tosi ◽  
Salvatore Saccone
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Nuclear Location

scholarly journals Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line

2000 ◽  
Vol 275 (20) ◽  
pp. 15226-15231 ◽  
Author(s):  
Vincenzo De Laurenzi ◽  
Giuseppe Raschellá ◽  
Daniela Barcaroli ◽  
Margherita Annicchiarico-Petruzzelli ◽  
Marco Ranalli ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line

Proteins involved in neuronal differentiation of neuroblastoma cell line N1E-115

2007 ◽  
Vol 28 (12) ◽  
pp. 2009-2017 ◽  
Author(s):  
Ji-eun Oh ◽  
Angelika Freilinger ◽  
Ellen Gelpi ◽  
Arnold Pollak ◽  
Markus Hengstschläger ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line

scholarly journals Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation

2001 ◽  
Vol 268 (5) ◽  
pp. 1352-1362 ◽  
Author(s):  
Alain Lombet ◽  
Violetta Zujovic ◽  
Mustapha Kandouz ◽  
Claude Billardon ◽  
Santos Carvajal-Gonzalez ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Induced Apoptosis

PPARβ agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y

2007 ◽  
Vol 211 (3) ◽  
pp. 837-847 ◽  
Author(s):  
S. Di Loreto ◽  
B. D'Angelo ◽  
M.A. D'Amico ◽  
E. Benedetti ◽  
L. Cristiano ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line
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