scholarly journals Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression

Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 19559-19574 ◽  
Author(s):  
Chiara Ciardiello ◽  
Maria Serena Roca ◽  
Alessia Noto ◽  
Francesca Bruzzese ◽  
Tania Moccia ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Primary Cultures ◽  
Erbb Receptors ◽  
Synergistic Antitumor Activity

scholarly journals MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

2011 ◽  
Vol 18 (6) ◽  
pp. 711-719 ◽  
Author(s):  
Patrick Brest ◽  
Sandra Lassalle ◽  
Veronique Hofman ◽  
Olivier Bordone ◽  
Virginie Gavric Tanga ◽  
...  
Keyword(s):  
Cell Death ◽  
Thyroid Cancer ◽  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Trichostatin A ◽  
Primary Cultures ◽  
Cancer Drugs ◽  
Deacetylase Inhibitor ◽  
Thyroid Cancer Cells

The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, the aim of this study was to characterize HDACi-induced miRNAs and to determine their functional importance in the induction of cell death alone or in combination with other cancer drugs. Two HDACi, trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death in BCPAP, TPC-1, 8505C, and CAL62 cell lines and in primary cultures of papillary thyroid cancer (PTC) cells. In addition, miR-129-5p alone was sufficient to induce cell death and knockdown experiments showed that expression of this miRNA was required for HDACi-induced cell death. Moreover, miR-129-5p accentuated the anti-proliferative effects of other cancer drugs such as etoposide or human α-lactalbumin made lethal for tumor cells (HAMLET). Taken together, our data show that miR-129-5p is involved in the antitumor activity of HDACi and highlight a miRNA-driven cell death mechanism.

A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

2008 ◽  
Vol 51 (8) ◽  
pp. 2350-2353 ◽  
Author(s):  
Philip Jones ◽  
Sergio Altamura ◽  
Raffaele De Francesco ◽  
Odalys Gonzalez Paz ◽  
Olaf Kinzel ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors
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