scholarly journals Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1

Oncotarget ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 10271-10282 ◽  
Author(s):  
Qiwei Li ◽  
Ming Zhan ◽  
Wei Chen ◽  
Benpeng Zhao ◽  
Kai Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Cisplatin Resistance ◽  
Tract Cancer ◽  
Phenylethyl Isothiocyanate

scholarly journals MiR-200c-3p Modulates Cisplatin Resistance in Biliary Tract Cancer by ZEB1-Independent Mechanisms

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3996
Author(s):  
Florian Posch ◽  
Felix Prinz ◽  
Amar Balihodzic ◽  
Christian Mayr ◽  
Tobias Kiesslich ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Cisplatin Resistance ◽  
Epithelial Mesenchymal Transition ◽  
Gene Expression Pattern ◽  
Underlying Mechanism ◽  
P Value ◽  
Mesenchymal Transition ◽  
Tract Cancer

Biliary tract cancer is a major global health issue in cancer-related mortality. Therapeutic options are limited, and cisplatin-based treatment schedules represent the mainstay of first-line therapeutic strategies. Although the gain of survival by the addition of cisplatin to gemcitabine is moderate, acquired cisplatin resistance frequently leads to treatment failures with mechanisms that are still poorly understood. Epithelial–mesenchymal transition (EMT) is a dynamic process that changes the shape, function, and gene expression pattern of biliary tract cancer cells. In this study, we explored the influence of the EMT-regulating miR-200c-3p on cisplatin sensitivity in biliary tract cancer cells. Using gain of function experiments, we demonstrated that miR-200c-3p regulates epithelial cell markers through the downregulation of the transcription factor ZEB1. MiR-200c-3p upregulation led to a decreased sensitivity against cisplatin, as observed in transient overexpression models as well as in cell lines stably overexpressing miR-200c-3p. The underlying mechanism seems to be independent of miR-200c-3p’s influence on ZEB1 expression, as ZEB1 knockdown resulted in the opposite effect on cisplatin resistance, which was abolished when ZEB1 knockdown and miR-200c-3p overexpression occurred in parallel. Using a gene panel of 40 genes that were previously associated with cisplatin resistance, two (Dual Specificity Phosphatase 16 (DUSP16) and Stratifin (SFN)) were identified as significantly (>2 fold, p-value < 0.05) up-regulated in miR-200c-3p overexpressing cells. In conclusion, miR-200c-3p might be an important contributor to cisplatin resistance in biliary tract cancer, independently of its interaction with ZEB1.

scholarly journals CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells

2011 ◽  
Vol 27 (4) ◽  
pp. 1266-1276 ◽  
Author(s):  
JIAN-HUA YU ◽  
XIANG-YU ZHONG ◽  
WEI-GUANG ZHANG ◽  
ZHI-DONG WANG ◽  
QIN DONG ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Suppressor Gene ◽  
Tract Cancer

DZNep may directly target putative cancer stem cells in biliary tract cancer cells by inhibition of PRC2

2014 ◽  
Vol 52 (08) ◽  
Author(s):  
C Mayr ◽  
A Wagner ◽  
A Stöcklinger ◽  
M Jakab ◽  
R Illig ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Tract Cancer

Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody–cytotoxic drug conjugate

2019 ◽  
Vol 83 (4) ◽  
pp. 659-671 ◽  
Author(s):  
Yoriko Yamashita-Kashima ◽  
Yasushi Yoshimura ◽  
Takaaki Fujimura ◽  
Sei Shu ◽  
Mieko Yanagisawa ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Cytotoxic Drug ◽  
Molecular Targeting ◽  
Trastuzumab Emtansine ◽  
Drug Conjugate ◽  
Tract Cancer

scholarly journals Aberrant expression of the PHF14 gene in biliary tract cancer cells

2013 ◽  
Vol 5 (6) ◽  
pp. 1849-1853 ◽  
Author(s):  
TAKAKO AKAZAWA ◽  
KOHICHIROH YASUI ◽  
YASUYUKI GEN ◽  
NOBUHISA YAMADA ◽  
AKIRA TOMIE ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Aberrant Expression ◽  
Tract Cancer

scholarly journals Disrupted transforming growth factor-? signaling and deregulated growth in human biliary tract cancer cells

2000 ◽  
Vol 86 (6) ◽  
pp. 782-789 ◽  
Author(s):  
Shujiro Yazumi ◽  
Kohaku Ko ◽  
Norihiko Watanabe ◽  
Hisashi Shinohara ◽  
Kiyotsugu Yoshikawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Transforming Growth Factor ◽  
Growth Factor Signaling ◽  
Tract Cancer

scholarly journals Cytotoxic effects of chemokine receptor 4 inhibition by AMD3100 in biliary tract cancer cells: Potential drug synergism with gemcitabine

2015 ◽  
Vol 12 (2) ◽  
pp. 2247-2252 ◽  
Author(s):  
CHRISTIAN MAYR ◽  
DANIEL NEUREITER ◽  
MARTIN PICHLER ◽  
FRIEDER BERR ◽  
ANDREJ WAGNER ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biliary Tract ◽  
Chemokine Receptor ◽  
Biliary Tract Cancer ◽  
Drug Synergism ◽  
Potential Drug ◽  
Cytotoxic Effects ◽  
Tract Cancer ◽  
Chemokine Receptor 4
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