scholarly journals Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation

Oncotarget ◽  
2015 ◽  
Vol 6 (35) ◽  
pp. 37544-37556 ◽  
Author(s):  
XiangJian Chen ◽  
KeQing Shi ◽  
YuQun Wang ◽  
Mei Song ◽  
Wu Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Experimental Validation ◽  
Clinical Value ◽  
Mirna Expression Profiling ◽  
Profiling Analysis

scholarly journals Left-Sided Colorectal Cancer Distinct in Indigenous African Patients Compared to Other Ethnic Groups in South Africa.

2021 ◽  
Author(s):  
M. McCabe ◽  
C. Penny ◽  
P. Magangane ◽  
S. Mirza ◽  
Y. Perner
Keyword(s):  
Colorectal Cancer ◽  
South Africa ◽  
Ethnic Groups ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Expression Patterns ◽  
Molecular Characteristics ◽  
Anatomical Site ◽  
Molecular Features ◽  
Mirna Expression Profiling

Abstract Introduction: A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (<50years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological and miRNA expression patterns in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease. Methods: A retrospective cohort (2011-2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [Right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer’s exact and Chi-square tests were conducted. Additional miRNA expression profiling was performed on IA patient samples. Results: IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association. MiRNA expression profiling revealed unique clustering, with dysregulation of let-7 and miRNA-125. Conclusion: This study revealed distinct histopathological features for LCC, and suggests BAT25/26, miRNAs let-7a-5p and miRNA-125a/b-5p as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended.

scholarly journals Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer

2015 ◽  
Vol 6 (1) ◽  
pp. e1614-e1614 ◽  
Author(s):  
R Vishnubalaji ◽  
R Hamam ◽  
M-H Abdulla ◽  
M A V Mohammed ◽  
M Kassem ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Regulatory Networks ◽  
Genome Wide ◽  
Mirna Expression Profiling

scholarly journals Identification of novel MiRNAs and MiRNA expression profiling during grain development in indica rice

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 264 ◽  
Author(s):  
Ying Lan ◽  
Ning Su ◽  
Yi Shen ◽  
Rongzhi Zhang ◽  
Fuqing Wu ◽  
...  
Keyword(s):  
Mirna Expression ◽  
Expression Profiling ◽  
Indica Rice ◽  
Grain Development ◽  
Mirna Expression Profiling

Hepatic miRNA expression profiling in genetically modified mouse models of different atherosclerosis susceptibility

2016 ◽  
Vol 252 ◽  
pp. e206-e207
Author(s):  
S. Manzini ◽  
M. Busnelli ◽  
M. Chiara ◽  
C. Parolini ◽  
F. Dellera ◽  
...  
Keyword(s):  
Mouse Models ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Genetically Modified ◽  
Mirna Expression Profiling
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