scholarly journals Time‐resolved mRNA and miRNA expression profiling reveals crucial coregulation of molecular pathways involved in epithelial–pneumococcal interactions

2020 ◽  
Vol 98 (9) ◽  
pp. 726-742 ◽  
Author(s):  
Haiyan Li ◽  
Li Lin ◽  
Lei Chong ◽  
Shuge Gu ◽  
Shunhang Wen ◽  
...  
Keyword(s):  
Mirna Expression ◽  
Expression Profiling ◽  
Molecular Pathways ◽  
Time Resolved ◽  
Mirna Expression Profiling

scholarly journals Identification of novel MiRNAs and MiRNA expression profiling during grain development in indica rice

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 264 ◽  
Author(s):  
Ying Lan ◽  
Ning Su ◽  
Yi Shen ◽  
Rongzhi Zhang ◽  
Fuqing Wu ◽  
...  
Keyword(s):  
Mirna Expression ◽  
Expression Profiling ◽  
Indica Rice ◽  
Grain Development ◽  
Mirna Expression Profiling

scholarly journals Left-Sided Colorectal Cancer Distinct in Indigenous African Patients Compared to Other Ethnic Groups in South Africa.

2021 ◽  
Author(s):  
M. McCabe ◽  
C. Penny ◽  
P. Magangane ◽  
S. Mirza ◽  
Y. Perner
Keyword(s):  
Colorectal Cancer ◽  
South Africa ◽  
Ethnic Groups ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Expression Patterns ◽  
Molecular Characteristics ◽  
Anatomical Site ◽  
Molecular Features ◽  
Mirna Expression Profiling

Abstract Introduction: A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (<50years), with no unique histopathological or molecular characteristics. Anatomical site as well as microsatellite instability (MSI) status have shown to be associated with different clinicopathological and molecular features. This study aimed to ascertain key histopathological and miRNA expression patterns in microsatellite stable (MSS) and low-frequency MSI (MSI-L) patients, to provide insight into the mechanism of the disease. Methods: A retrospective cohort (2011-2015) of MSS/MSI-L CRC patient samples diagnosed at Charlotte Maxeke Johannesburg Academic Hospital was analyzed. Samples were categorized by site [Right colon cancer (RCC) versus left (LCC)], ethnicity [IA versus other ethnic groups (OEG)] and MSI status (MSI-L vs MSS). T-test, Fischer’s exact and Chi-square tests were conducted. Additional miRNA expression profiling was performed on IA patient samples. Results: IA patients with LCC demonstrated an increased prevalence in males, sigmoid colon, signet-ring-cell morphology, MSI-L with BAT25/26 marker instability and advanced disease association. MiRNA expression profiling revealed unique clustering, with dysregulation of let-7 and miRNA-125. Conclusion: This study revealed distinct histopathological features for LCC, and suggests BAT25/26, miRNAs let-7a-5p and miRNA-125a/b-5p as negative prognostic markers in African CRC patients. Larger confirmatory studies are recommended.

Hepatic miRNA expression profiling in genetically modified mouse models of different atherosclerosis susceptibility

2016 ◽  
Vol 252 ◽  
pp. e206-e207
Author(s):  
S. Manzini ◽  
M. Busnelli ◽  
M. Chiara ◽  
C. Parolini ◽  
F. Dellera ◽  
...  
Keyword(s):  
Mouse Models ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Genetically Modified ◽  
Mirna Expression Profiling

scholarly journals miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples

2017 ◽  
Vol Volume 10 ◽  
pp. 4225-4238 ◽  
Author(s):  
Ovidiu-Leonard Braicu ◽  
Liviuta Budisan ◽  
Rares Buiga ◽  
Ancuta Jurj ◽  
Patriciu Achimas-Cadariu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Mirna Expression Profiling ◽  
Formalin Fixed

scholarly journals Identification of Differentially Expressed MicroRNAs in Osteosarcoma

Sarcoma ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Rishi R. Lulla ◽  
Fabricio F. Costa ◽  
Jared M. Bischof ◽  
Pauline M. Chou ◽  
Maria de F. Bonaldo ◽  
...  
Keyword(s):  
High Throughput ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Differentially Expressed ◽  
Pcr Analysis ◽  
Osteosarcoma Cell ◽  
Human Osteoblasts ◽  
Normal Human ◽  
Mirna Expression Profiling

A limited number of reports have investigated the role of microRNAs in osteosarcoma. In this study, we performed miRNA expression profiling of osteosarcoma cell lines, tumor samples, and normal human osteoblasts. Twenty-two differentially expressed microRNAs were identified using high throughput real-time PCR analysis, and 4 (miR-135b, miR-150, miR-542-5p, and miR-652) were confirmed and validated in a different group of tumors. Both miR-135b and miR-150 have been previously shown to be important in cancer. We hypothesize that dysregulation of differentially expressed microRNAs may contribute to tumorigenesis. They might also represent molecular biomarkers or targets for drug development in osteosarcoma.

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