scholarly journals miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1

Oncotarget ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 13491-13501 ◽  
Author(s):  
Yonglei Liu ◽  
Yutong Wang ◽  
Xiangjun Sun ◽  
Chuanzhong Mei ◽  
Liying Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals 2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL

2015 ◽  
Vol 21 ◽  
pp. 3442-3448 ◽  
Author(s):  
Yuping Zhang ◽  
Feizhou Huang ◽  
Jian Wang ◽  
Hongwu Luo ◽  
Zhichao Wang
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway

2019 ◽  
Vol Volume 12 ◽  
pp. 1765-1779 ◽  
Author(s):  
Yi Hou ◽  
Chunna Lan ◽  
Ying Kong ◽  
Chunjiao Zhu ◽  
Wenna Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Genetic Ablation ◽  
Cancer Cell Apoptosis

Sorafenib Affects Liver Cancer Cell Proliferation and Apoptosis by Regulating DJ-1-PTEN/PI3K/AKT Signaling Pathway

2020 ◽  
Vol 10 (8) ◽  
pp. 1219-1224
Author(s):  
Qiang Yu ◽  
Xiaoming Peng ◽  
Lihua Gong ◽  
Xiaoqiong Liu ◽  
Yuanyuan Shan
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Pten Expression ◽  
Akt Pathway ◽  
Cancer Cell Proliferation ◽  
Liver Cancer Cell ◽  
Sorafenib Treatment ◽  
L Cells

Objective: To assess sorafenib's role in regulating DJ-1-PTEN/PI3 K/AKT pathway and affecting the biological effects of liver cancer cells. Methods: Human normal liver HL-7702, liver cancer MHC97-L, and HCCLM3 cells were cultured in vitro to measure DJ-1 and PTEN expression. MHC97-L and HCCLM3 cells were treated with 0, 1.0, 2.0 M of sorafenib followed by analysis of cell viability by CCK-8, and DJ-1 and PTEN expressions by Western blot. MHC97-L cells were separated into control group, 2.0 M Sorafenib treatment group, Sorafenib + pcDNA3.1-Blank group, and Sorafenib + pcDNA3.1-DJ-1 group. Cell proliferation was assessed by flow cytometry and EdU staining. Results: Compared with HL-7702 cells, DJ-1 expression was significantly increased, while PTEN level was significantly declined in MHC97-L and HCCLM3 cells. Sorafenib treatment significantly inhibited the proliferation activity of MHC97-L and HCCLM3 cells. Different concentrations of sorafenib significantly downregulated DJ-1 expression and enhanced PTEN expression in MHC97-L cells. pcDNA3.1-DJ-1 transfection on the basis of sorafenib treatment significantly elevated DJ-1 and p -AKT levels, reduced PTEN expression, decreased cell apoptosis, and enhanced cell proliferation. Conclusion: Sorafenib downregulates DJ-1 expression and affects PTEN/PI3K/AKT pathway activity to exert an anti-tumor effect that inhibits liver cancer cell proliferation and promotes cell apoptosis.

scholarly journals AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer

2021 ◽  
Vol 45 (6) ◽  
Author(s):  
Zhuo Xiang ◽  
Qing Miao ◽  
Jin Zhang ◽  
Guoxin Liu ◽  
Shuyi Xue ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Notch Signaling ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

scholarly journals Downregulation of PITX2 inhibits the proliferation and migration of liver cancer cells and induces cell apoptosis

2021 ◽  
Vol 16 (1) ◽  
pp. 1322-1329
Author(s):  
Kebinuer Tuerxun ◽  
Shufang Zhang ◽  
Yuexin Zhang
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Cell Apoptosis ◽  
Migration And Invasion ◽  
Liver Cancer Cell ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Pitx2 Expression

Abstract Paired-like homeodomain 2 (PITX2) functions as a transcription factor to participate in vertebrate embryogenesis, and dysregulated PITX2 expression was associated with the progression of various cancers. The functional role of PITX2 in tumorigenesis of liver cancer remains unknown. Western blot analysis showed that expression levels of PITX2 were enhanced in the liver cancer tissues and cells. siRNAs targeting PITX2 induced downregulation of PITX2 in liver cancer cells. siRNA-induced knockdown of PITX2 decreased liver cancer cell viability and proliferation, while promoting cell apoptosis by increasing cleaved-PARP, cleaved caspase 3, and cleaved caspase 9. The knockdown of PITX2 repressed liver cancer cell migration and invasion. In conclusion, elevated PITX2 expression was associated with liver cancer progression through repression of cell apoptosis and promoting cell proliferation and metastasis, and silencing of PITX2 might serve as a potential therapeutic strategy for the treatment of liver cancer.

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