scholarly journals Ethanol Extract of Annona Muricata. L Induces liver Cancer Cell Apoptosis through ROS Pathway

2016 ◽  
Vol 9 (3) ◽  
pp. 919-925 ◽  
Author(s):  
HUALI YANG ◽  
NA LIU ◽  
SHAOCHIN LEE
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Ethanol Extract ◽  
Annona Muricata ◽  
Liver Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals 2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL

2015 ◽  
Vol 21 ◽  
pp. 3442-3448 ◽  
Author(s):  
Yuping Zhang ◽  
Feizhou Huang ◽  
Jian Wang ◽  
Hongwu Luo ◽  
Zhichao Wang
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1

Oncotarget ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 13491-13501 ◽  
Author(s):  
Yonglei Liu ◽  
Yutong Wang ◽  
Xiangjun Sun ◽  
Chuanzhong Mei ◽  
Liying Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway

2019 ◽  
Vol Volume 12 ◽  
pp. 1765-1779 ◽  
Author(s):  
Yi Hou ◽  
Chunna Lan ◽  
Ying Kong ◽  
Chunjiao Zhu ◽  
Wenna Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Liver Cancer Cell ◽  
Genetic Ablation ◽  
Cancer Cell Apoptosis

Sorafenib Affects Liver Cancer Cell Proliferation and Apoptosis by Regulating DJ-1-PTEN/PI3K/AKT Signaling Pathway

2020 ◽  
Vol 10 (8) ◽  
pp. 1219-1224
Author(s):  
Qiang Yu ◽  
Xiaoming Peng ◽  
Lihua Gong ◽  
Xiaoqiong Liu ◽  
Yuanyuan Shan
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Pten Expression ◽  
Akt Pathway ◽  
Cancer Cell Proliferation ◽  
Liver Cancer Cell ◽  
Sorafenib Treatment ◽  
L Cells

Objective: To assess sorafenib's role in regulating DJ-1-PTEN/PI3 K/AKT pathway and affecting the biological effects of liver cancer cells. Methods: Human normal liver HL-7702, liver cancer MHC97-L, and HCCLM3 cells were cultured in vitro to measure DJ-1 and PTEN expression. MHC97-L and HCCLM3 cells were treated with 0, 1.0, 2.0 M of sorafenib followed by analysis of cell viability by CCK-8, and DJ-1 and PTEN expressions by Western blot. MHC97-L cells were separated into control group, 2.0 M Sorafenib treatment group, Sorafenib + pcDNA3.1-Blank group, and Sorafenib + pcDNA3.1-DJ-1 group. Cell proliferation was assessed by flow cytometry and EdU staining. Results: Compared with HL-7702 cells, DJ-1 expression was significantly increased, while PTEN level was significantly declined in MHC97-L and HCCLM3 cells. Sorafenib treatment significantly inhibited the proliferation activity of MHC97-L and HCCLM3 cells. Different concentrations of sorafenib significantly downregulated DJ-1 expression and enhanced PTEN expression in MHC97-L cells. pcDNA3.1-DJ-1 transfection on the basis of sorafenib treatment significantly elevated DJ-1 and p -AKT levels, reduced PTEN expression, decreased cell apoptosis, and enhanced cell proliferation. Conclusion: Sorafenib downregulates DJ-1 expression and affects PTEN/PI3K/AKT pathway activity to exert an anti-tumor effect that inhibits liver cancer cell proliferation and promotes cell apoptosis.

scholarly journals AB4 inhibits Notch signaling and promotes cancer cell apoptosis in liver cancer

2021 ◽  
Vol 45 (6) ◽  
Author(s):  
Zhuo Xiang ◽  
Qing Miao ◽  
Jin Zhang ◽  
Guoxin Liu ◽  
Shuyi Xue ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Notch Signaling ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis
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