scholarly journals The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Michał Dobrakowski ◽  
Marta Boroń ◽  
Ewa Birkner ◽  
Aleksandra Kasperczyk ◽  
Ewa Chwalińska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Essential Metals ◽  
Short Term ◽  
Oxidative Stress Parameters ◽  
Short Term Exposure ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
And Oxidative Stress ◽  
Stress Parameters

The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally exposed to lead for 36 to 44 days. Their blood lead level at the beginning of the study was 10.7 ± 7.67 μg/dl and increased to the level of 49.1 ± 14.1 μg/dl at the end of the study. The levels of calcium, magnesium, and zinc increased significantly after lead exposure compared to baseline by 3%, 3%, and 8%, respectively, while the level of copper decreased significantly by 7%. The malondialdehyde (MDA) level and the activities of catalase (CAT) and superoxide dismutase (SOD) did not change due to lead exposure. However, the level of lipid hydroperoxides (LPH) in serum increased significantly by 46%, while the level of erythrocyte lipofuscin (LPS) decreased by 13%. The serum levels of essential metals are modified by a short-term exposure to lead in occupationally exposed workers. A short-term exposure to lead induces oxidative stress associated with elevated levels of LPH but not MDA.

scholarly journals DYNAMICS OF PHOTOSYNTHETIC AND OXIDATIVE STRESS PARAMETERS OF TWO SPINACH SPECIES AFTER SHORT-TERM LOW UV-B RADIATION EFFECT

2019 ◽  
Vol 18 (1) ◽  
pp. 141-149
Author(s):  
Irena Januškaitienė ◽  
Sandra Sakalauskienė
Keyword(s):  
Oxidative Stress ◽  
Photosynthetic Rate ◽  
Radiation Effect ◽  
Radical Scavenging ◽  
Short Term ◽  
Oxidative Stress Parameters ◽  
Scavenging Capacity ◽  
Positive Effect ◽  
And Oxidative Stress ◽  
Stress Parameters

This work aimed to underline the dynamics of photosynthetic and oxidative stress parameters of ‘Matador’ and ‘Andromeda’ spinach species after short-term 1 and 2 kJm–2 UV-B radiation effect. When plants reached 3–4 leaves growths stage, the exposure to 1 kJm–2 and 2 kJm–2 UV-B radiation was done once for 68 and 136 minutes, respectively. The photosynthetic and oxidative stress parameters were determined 2, 24, 48 and 72 hours after exposure. The stimulating effect of UV-B emerged on the 3rd day after exposure. The positive effect of UV-B was more pronounced for ‘Matador’. The highest DPPH radical-scavenging capacity and the highest concentration of α-tocopherols were detected 24 hours after 2 kJ UV-B exposure, but the decrease in photosynthetic rate was the highest as well. Meanwhile, on the 3rd day after 1 kJ UV-B exposure, the indicators of oxidative stress of ‘Matador’ decreased, and the photosynthetic rate increased. This study highlights that low UV-B radiation acts as an eustress, by awaking positive changes in photosynthetic and oxidative stress parameters of spinach.

Decreased paraoxonase 1 activity and increased oxidative stress in low lead−exposed workers

2011 ◽  
Vol 30 (9) ◽  
pp. 1196-1203 ◽  
Author(s):  
Thinnakorn Permpongpaiboon ◽  
Amar Nagila ◽  
Phannee Pidetcha ◽  
Kulwadee Tuangmungsakulchai ◽  
Soontharee Tantrarongroj ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Linear Regression Analysis ◽  
Exposed Group ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Control Group ◽  
Oxidative Stress Parameters ◽  
Exposed Workers ◽  
Stress Parameters

Paraoxonase 1 (PON1) has been proposed as an antioxidant enzyme. Although lead-inhibited PON1 activity has been demonstrated mostly based on in vitro experiments, it is uncertain whether this phenomenon is relevant in pathogenesis of lead-induced oxidative stress in the lead exposure. We examined associations of blood lead levels (BLL) and PON1 activity along with oxidative stress parameters in lead exposure workers. We determined malondialdehyde (MDA), conjugated diene (CD), total peroxides (TP), total antioxidant status (TAS), the oxidative stress index (OSI), and PON1 activity in earthenware factory workers ( n = 60) and control subjects ( n = 65). The lead-exposed group significantly increased lipid peroxidation parameters and OSI compared to the control group ( p < 0.001). The lead-exposed group had significantly decreased PON1 activity and TAS levels compared to the control group ( p < 0.001). Multiple linear regression analysis revealed that BLL were significantly correlated with decreased TAS ( r = −0.496) and PON1 activity ( r = −0.434), but with increased CD ( r = 0.694), TP ( r = 0.614), MDA ( r = 0.788), and OSI ( r = 0.722). Interestingly, BLL at 10 µg/dL significantly decreased PON1 activity and increased oxidative stress parameters with insignificant changes in other biochemical and hematological parameters. Altogether, the reduction of PON1 activity may associate in an imbalance in pro-oxidants and antioxidants, leading to oxidative damage in lead-exposed workers even at low BLL.

Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration

2016 ◽  
Vol 32 (2) ◽  
pp. 519-528 ◽  
Author(s):  
Lara M. Gomes ◽  
Milena Carvalho-Silva ◽  
Letícia J. Teixeira ◽  
Joyce Rebelo ◽  
Isabella T. Mota ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Mood Stabilizers ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Behavior and oxidative stress parameters in rats subjected to the animal's models induced by chronic mild stress and 6-hydroxydopamine

2021 ◽  
Vol 406 ◽  
pp. 113226
Author(s):  
Talita Tuon ◽  
Sandra S. Meirelles ◽  
Airam B. de Moura ◽  
Thayse Rosa ◽  
Laura A. Borba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Oxidative Stress Parameters ◽  
6 Hydroxydopamine ◽  
And Oxidative Stress ◽  
Stress Parameters

Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Jennifer Chidera Awurum ◽  
Sunday Amos Onikanni ◽  
Adedotun Adefolalu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Role ◽  
Diabetic Rats ◽  
Gene Expressions ◽  
Ki 67 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

scholarly journals The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation, and Oxidative Stress Parameters and Fecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity—PRO-DEMET Randomized Study Protocol

2021 ◽  
Vol 10 (7) ◽  
pp. 1342
Author(s):  
Oliwia Gawlik-Kotelnicka ◽  
Anna Skowrońska ◽  
Aleksandra Margulska ◽  
Karolina H. Czarnecka-Chrebelska ◽  
Igor Łoniewski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Study Protocol ◽  
Bifidobacterium Longum ◽  
White Blood Cells ◽  
Fecal Microbiota ◽  
Probiotic Supplementation ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.

MS97 THE EFFECT OF THE n-3/n-6 PUFA RATIO ON THE TRANSFORMATION OF POSTPRANDIAL STATE PROATHEROGENIC LDL PHENOTYPE AND OXIDATIVE STRESS PARAMETERS

2010 ◽  
Vol 11 (2) ◽  
pp. 129-130 ◽  
Author(s):  
A. Dembinska-Kiec ◽  
M. Malczewska-Malec ◽  
H. Roche ◽  
I. Leszczynska-Golabek ◽  
J. Hartwich ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pufa Ratio ◽  
Oxidative Stress Parameters ◽  
Postprandial State ◽  
And Oxidative Stress ◽  
Stress Parameters
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