scholarly journals Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells

Oncotarget ◽  
2015 ◽  
Vol 6 (10) ◽  
pp. 7959-7969 ◽  
Author(s):  
Rafael Soares Lindoso ◽  
Federica Collino ◽  
Giovanni Camussi
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Extracellular Vesicles ◽  
Renal Cancer ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Renal Cancer Stem Cells

scholarly journals Dendritic-cell-based immunotherapy evokes potent anti-tumor immune responses in CD105+ human renal cancer stem cells

2017 ◽  
Vol 56 (11) ◽  
pp. 2499-2511 ◽  
Author(s):  
Xiao-Fei Zhang ◽  
De-sheng Weng ◽  
Ke Pan ◽  
Zi-Qi Zhou ◽  
Qiu-zhong Pan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dendritic Cell ◽  
Cancer Stem Cells ◽  
Immune Responses ◽  
Renal Cancer ◽  
Renal Cancer Stem Cells

scholarly journals Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

2011 ◽  
Vol 71 (15) ◽  
pp. 5346-5356 ◽  
Author(s):  
Cristina Grange ◽  
Marta Tapparo ◽  
Federica Collino ◽  
Loriana Vitillo ◽  
Christian Damasco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Renal Cancer ◽  
Premetastatic Niche ◽  
Renal Cancer Stem Cells

Wharton's jelly mesenchymal stromal cells have contrasting effects on proliferation and phenotype of cancer stem cells from different subtypes of lung cancer

2016 ◽  
Vol 345 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Francesca Vulcano ◽  
Luisa Milazzo ◽  
Carmela Ciccarelli ◽  
Adriana Eramo ◽  
Giovanni Sette ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Wharton’S Jelly ◽  
Wharton's Jelly

scholarly journals MP067MICRORNA PROFILING USING NEXT-GENERATION SEQUENCING IN RENAL CANCER STEM CELLS: A NEW REGULATORY MECHANISM

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii450-iii450
Author(s):  
Grazia Serino ◽  
Fabio Sallustio ◽  
Vanessa Galleggiante ◽  
Monica Rutigliano ◽  
Claudia Curci ◽  
...  
Keyword(s):  
Stem Cells ◽  
Next Generation Sequencing ◽  
Cancer Stem Cells ◽  
Renal Cancer ◽  
Regulatory Mechanism ◽  
Next Generation ◽  
Renal Cancer Stem Cells ◽  
Generation Sequencing

Targeting Strategies for Renal Cancer Stem Cell Therapy

2020 ◽  
Vol 26 (17) ◽  
pp. 1964-1978 ◽  
Author(s):  
Pengchao Fang ◽  
Liuting Zhou ◽  
Lee Y. Lim ◽  
Hualin Fu ◽  
Zhi-xiang Yuan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Cell Carcinoma ◽  
Stem Cell ◽  
Targeted Therapy ◽  
Cancer Stem Cells ◽  
Renal Cancer ◽  
Treatment Resistance ◽  
Treatment Efficiency ◽  
Renal Carcinogenesis ◽  
Renal Cancer Stem Cells

Renal cell carcinoma (RCC) is an intractable genitourinary malignancy that accounts for approximately 4% of adult malignancies. Currently, there is no approved targeted therapy for RCC that has yielded durable remissions, and they remain palliative in intent. Emerging evidence has indicated that renal tumorigenesis and RCC treatment-resistance may originate from renal cancer stem cells (CSCs) with tumor-initiating capacity (CSC hypothesis). A better understanding of the mechanism underlying renal CSCs will help to dissect RCC heterogeneity and drug treatment efficiency, to promote more personalized and targeted therapies. In this review, we summarized the stem cell characteristics of renal CSCs. We outlined the targeting strategies and challenges associated with developing therapies that target renal CSCs angiogenesis, immunosuppression, signaling pathways, surface biomarkers, microRNAs and nanomedicine. In conclusion, CSCs are an important role in renal carcinogenesis and represent a valid target for treatment of RCC patients.

BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation

2014 ◽  
Vol 141 (6) ◽  
pp. 1013-1024 ◽  
Author(s):  
Lin Wang ◽  
Paul Park ◽  
Frank La Marca ◽  
Khoi D. Than ◽  
Chia-Ying Lin
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Bone Formation ◽  
Renal Cancer ◽  
Renal Cancer Stem Cells

scholarly journals Differentiation Therapy: Targeting Human Renal Cancer Stem Cells with Interleukin 15

2011 ◽  
Vol 103 (24) ◽  
pp. 1884-1898 ◽  
Author(s):  
Sandy Azzi ◽  
Stefania Bruno ◽  
Julien Giron-Michel ◽  
Denis Clay ◽  
Aurore Devocelle ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Renal Cancer ◽  
Differentiation Therapy ◽  
Interleukin 15 ◽  
Renal Cancer Stem Cells

scholarly journals Development of extracellular matrix supported 3D culture of renal cancer cells and renal cancer stem cells

2018 ◽  
Vol 71 (1) ◽  
pp. 149-163 ◽  
Author(s):  
Kamila Maliszewska-Olejniczak ◽  
Klaudia K. Brodaczewska ◽  
Zofia F. Bielecka ◽  
Wojciech Solarek ◽  
Anna Kornakiewicz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Renal Cancer ◽  
3D Culture ◽  
Renal Cancer Stem Cells
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