scholarly journals 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 5695-5706 ◽  
Author(s):  
Giada Poli ◽  
Elisabetta Ceni ◽  
Roberta Armignacco ◽  
Tonino Ercolino ◽  
Letizia Canu ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Proteomic Analysis ◽  
Therapeutic Targets ◽  
2D Dige

scholarly journals Proteomic analysis of ovomucoid hypersensitivity in mice by two-dimensional difference gel electrophoresis (2D-DIGE)

2007 ◽  
Vol 45 (12) ◽  
pp. 2372-2380 ◽  
Author(s):  
D.J. Hobson ◽  
P. Rupa ◽  
G.J. Diaz ◽  
H. Zhang ◽  
M. Yang ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Gel Electrophoresis ◽  
Two Dimensional ◽  
2D Dige ◽  
Difference Gel Electrophoresis

Proteomic analysis of follicular fluid from women with and without endometriosis: New therapeutic targets and biomarkers

2013 ◽  
Vol 80 (6) ◽  
pp. 441-450 ◽  
Author(s):  
Edson Guimarães Lo Turco ◽  
Fernanda Bertuccez Cordeiro ◽  
Paula Helena de Carvalho Lopes ◽  
Fábio Cesar Gozzo ◽  
Eduardo Jorge Pilau ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Proteomic Analysis ◽  
Therapeutic Targets ◽  
New Therapeutic Targets

scholarly journals 2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I

Molecules ◽  
2011 ◽  
Vol 16 (4) ◽  
pp. 3048-3065 ◽  
Author(s):  
Zhong-Chao Wang ◽  
Du E ◽  
De-Ligen Batu ◽  
Ya-Latu Saixi ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
2D Dige ◽  
Breast Hyperplasia

scholarly journals Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shenjie Li ◽  
Wei Xiang ◽  
Junjie Tian ◽  
Haorun Wang ◽  
Shuiwang Hu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Proteomic Analysis ◽  
Differentially Expressed ◽  
Migration And Invasion ◽  
Differentially Expressed Proteins ◽  
C6 Cells ◽  
2D Dige

Bone marrow-derived mesenchymal stem cells (BM-MSCs) display high tumor tropism and cause indirect effects through the cytokines they secrete. However, the effects of BM-MSCs on the biological behaviors of glioblastoma multiforme remain unclear. In this study, the conditioned medium from BM-MSCs significantly inhibited the proliferation of C6 cells ( P < 0.05 ) but promoted their migration and invasion ( P < 0.05 ). Two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) proteomic analysis revealed 17 proteins differentially expressed in C6 cells exposed to the BM-MSC-conditioned medium including five upregulated proteins and 12 downregulated proteins. Among these, six differentially expressed proteins (Calr, Set, Oat, Npm1, Ddah1, and Tardbp) were closely related to cell proliferation and differentiation, and nine proteins (Pdia6, Sphk1, Anxa4, Vim, Tuba1c, Actr1b, Actn4, Rap2c, and Tpm2) were associated with motility and the cytoskeleton, which may modulate the invasion and migration of tumor cells. Above all, by identifying the differentially expressed proteins using proteomics and bioinformatics analysis, BM-MSCs could be genetically modified to specifically express tumor-suppressive factors when BM-MSCs are to be used as tumor-selective targeting carriers in the future.

Proteomic Analysis of Influenza a Virus Infected Mammalian Cells by 2D-DIGE

2010 ◽  
pp. 429-432
Author(s):  
D. Vester ◽  
E. Rapp ◽  
Y. Genzel ◽  
D. Gade ◽  
U. Reichl
Keyword(s):  
Influenza A Virus ◽  
Proteomic Analysis ◽  
Mammalian Cells ◽  
Influenza A ◽  
2D Dige
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