scholarly journals Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast

Oncotarget ◽  
2021 ◽  
Author(s):  
Karamat Mohammad ◽  
Emmanuel Orfanos ◽  
Vladimir I. Titorenko
Keyword(s):  
Caloric Restriction ◽  
Budding Yeast ◽  
Quiescent Cells

scholarly journals Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast

2020 ◽  
Vol 21 (13) ◽  
pp. 4717
Author(s):  
Karamat Mohammad ◽  
Jennifer Anne Baratang Junio ◽  
Tala Tafakori ◽  
Emmanuel Orfanos ◽  
Vladimir I. Titorenko
Keyword(s):  
Caloric Restriction ◽  
Budding Yeast ◽  
Yeast Cells ◽  
Yeast Culture ◽  
Chronological Aging ◽  
Quiescent Cells ◽  
Cellular Events ◽  
Age Related ◽  
Calorie Diet ◽  
Cellular Quiescence

After Saccharomyces cerevisiae cells cultured in a medium with glucose consume glucose, the sub-populations of quiescent and non-quiescent cells develop in the budding yeast culture. An age-related chronology of quiescent and non-quiescent yeast cells within this culture is discussed here. We also describe various hallmarks of quiescent and non-quiescent yeast cells. A complex aging-associated program underlies cellular quiescence in budding yeast. This quiescence program includes a cascade of consecutive cellular events orchestrated by an intricate signaling network. We examine here how caloric restriction, a low-calorie diet that extends lifespan and healthspan in yeast and other eukaryotes, influences the cellular quiescence program in S. cerevisiae. One of the main objectives of this review is to stimulate an exploration of the mechanisms that link cellular quiescence to chronological aging of budding yeast. Yeast chronological aging is defined by the length of time during which a yeast cell remains viable after its growth and division are arrested, and it becomes quiescent. We propose a hypothesis on how caloric restriction can slow chronological aging of S. cerevisiae by altering the chronology and properties of quiescent cells. Our hypothesis posits that caloric restriction delays yeast chronological aging by targeting four different processes within quiescent cells.

scholarly journals Domestication reprogrammed the budding yeast life cycle

2020 ◽  
Author(s):  
Matteo De Chiara ◽  
Benjamin Barré ◽  
Karl Persson ◽  
Amadi Onyetuga Chioma ◽  
Agurtzane Irizar ◽  
...  
Keyword(s):  
Life Cycle ◽  
Evolutionary History ◽  
Budding Yeast ◽  
World Population ◽  
Model Species ◽  
Quiescent Cells ◽  
Gamete Formation ◽  
The World ◽  
Wild Yeasts ◽  
Yeast Evolution

AbstractDomestication of plants and animals is the foundation for feeding the world population. We report that domestication of the model yeast S. cerevisiae reprogrammed its life cycle entirely. We tracked growth, gamete formation and cell survival across many environments for nearly 1000 genome sequenced isolates and found a remarkable dichotomy between domesticated and wild yeasts. Wild yeasts near uniformly trigger meiosis and sporulate when encountering nutrient depletions, whereas domestication relaxed selection on sexual reproduction and favoured survival as quiescent cells. Domestication also systematically enhanced fermentative over respiratory traits while decreasing stress tolerance. We show that this yeast domestication syndrome was driven by aneuploidies and gene function losses that emerged independently in multiple domesticated lineages during the specie’s recent evolutionary history. We found domestication to be the most dramatic event in budding yeast evolution, raising questions on how much domestication has distorted our understanding of this key model species.

Obesity reduction by physical activity and caloric restriction: standard care versus personalised management

2004 ◽  
Vol 29 (05) ◽  
Author(s):  
N Byrne ◽  
A Hills ◽  
J Meerkin ◽  
R Ross ◽  
R Laukkanen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Caloric Restriction ◽  
Standard Care
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