scholarly journals Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer

Oncotarget ◽  
2020 ◽  
Vol 11 (46) ◽  
pp. 4253-4265
Author(s):  
Erika Heninger ◽  
Nan Sethakorn ◽  
David Kosoff ◽  
Peiman Hematti ◽  
Morgan D. Kuczler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
High Risk ◽  
Bone Marrow Microenvironment ◽  
Localized Prostate Cancer ◽  
Immune Profiling

PO-1196: long term results with moderately hypofractionated RT in high-risk localized prostate cancer.

2020 ◽  
Vol 152 ◽  
pp. S630
Author(s):  
S. Maulik ◽  
I. Mallick ◽  
M. Arunsingh ◽  
S. Chatterjee ◽  
R. Achari ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Localized Prostate Cancer ◽  
Long Term Results

scholarly journals Hypofractionated radiotherapy versus conventional radiotherapy in patients with intermediate- to high-risk localized prostate cancer: a meta-analysis of randomized controlled trials

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Wei Guo ◽  
Yun-Chuan Sun ◽  
Jian-Qiang Bi ◽  
Xin-Ying He ◽  
Li Xiao
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Adverse Events ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Localized Prostate Cancer ◽  
Hypofractionated Radiotherapy ◽  
Cancer Specific Survival ◽  
Conventional Radiotherapy ◽  
Results Of Treatment

Abstract Background Prostate cancer is one of the most common cancers in the world. The results of treatment after hypofractionated radiotherapy only have been reported from several small randomized clinical trials. Therefore, we conducted a meta-analysis to compare clinical outcomes of hypofractionated radiotherapy versus conventional radiotherapy in the treatment of intermediate- to high-risk localized prostate cancer. Methods Relevant studies were identified through searching related databases till August 2018. Hazard ratio (HR) or risk ratio (RR) with its corresponding 95% confidence interval (CI) was used as pooled statistics for all analyses. Results The meta-analysis results showed that overall survival (HR = 1.12, 95% CI: 0.93–1.35, p = 0.219) and prostate cancer-specific survival (HR = 1.29, 95% CI: 0.42–3.95, p = 0.661) were similar in two groups. The pooled data showed that biochemical failure was RR = 0.90, 95% CI: 0.76–1.07, p = 0.248. The incidence of acute adverse gastrointestinal events (grade ≥ 2) was higher in the hypofractionated radiotherapy (RR = 1.70, 95% CI: 1.12–2.56, p = 0.012); conversely, for late grade ≥ 2 gastrointestinal adverse events, a significant increase in the conventional radiotherapy was found (RR = 0.75, 95% CI: 0.61–0.91, p = 0.003). Acute (RR = 1.01, 95% CI: 0.89–1.15, p = 0.894) and late (RR = 0.98, 95% CI: 0.86–1.10, p = 0.692) genitourinary adverse events (grade ≥ 2) were similar for both treatment groups. Conclusion Results suggest that the efficacy and risk for adverse events are comparable for hypofractionated radiotherapy and conventional radiotherapy in the treatment of intermediate- to high-risk localized prostate cancer.

scholarly journals The prognostic impact of cytokeratin-positive cells in bone marrow of patients with localized prostate cancer

2002 ◽  
Vol 103 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Wolfgang Lilleby ◽  
Jahn M. Nesland ◽  
Sophie D. Fosså ◽  
Goran Torlakovic ◽  
Håkon Waehre ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Localized Prostate Cancer ◽  
Prognostic Impact

scholarly journals Prevalence of Prostate Cancer Metastases after Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment

Neoplasia ◽  
2012 ◽  
Vol 14 (5) ◽  
pp. 429-439 ◽  
Author(s):  
Younghun Jung ◽  
Yusuke Shiozawa ◽  
Jingcheng Wang ◽  
Natalie McGregor ◽  
Jinlu Dai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Molecular Basis ◽  
Bone Marrow Microenvironment ◽  
Cancer Metastases ◽  
Intravenous Inoculation

scholarly journals Undertreatment of High-Risk Localized Prostate Cancer in the California Latino Population

2018 ◽  
Vol 16 (11) ◽  
pp. 1353-1360 ◽  
Author(s):  
Daphne Y. Lichtensztajn ◽  
John T. Leppert ◽  
James D. Brooks ◽  
Sumit A. Shah ◽  
Weiva Sieh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Localized Prostate Cancer ◽  
Latino Population
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