scholarly journals The prognostic impact of cytokeratin-positive cells in bone marrow of patients with localized prostate cancer

2002 ◽  
Vol 103 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Wolfgang Lilleby ◽  
Jahn M. Nesland ◽  
Sophie D. Fosså ◽  
Goran Torlakovic ◽  
Håkon Waehre ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Localized Prostate Cancer ◽  
Prognostic Impact

Perioperative Activation of Disseminated Tumor Cells in Bone Marrow of Patients With Prostate Cancer

2009 ◽  
Vol 27 (10) ◽  
pp. 1549-1556 ◽  
Author(s):  
Dorothea Weckermann ◽  
Bernhard Polzer ◽  
Thomas Ragg ◽  
Andreas Blana ◽  
Günter Schlimok ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Tumor Cells ◽  
Cox Regression ◽  
Systemic Disease ◽  
Disseminated Tumor Cells ◽  
Comparative Genomic ◽  
Prognostic Impact ◽  
Primary Tumors ◽  
Cox Regression Analysis

Purpose The outcome of prostate cancer is highly unpredictable. To assess the dynamics of systemic disease and to identify patients at high risk for early relapse we followed the fate of disseminated tumor cells in bone marrow for up to 10 years and genetically analyzed such cells isolated at various stages of disease. Patients and Methods Nine hundred bone marrow aspirates from 384 patients were stained using the monoclonal antibody A45-B/B3 directed against cytokeratins 8, 18, and 19. Log-rank statistics and Cox regression analysis were applied to determine the prognostic impact of positive cells detected before surgery (244 patients) and postoperatively (214 patients). Samples from primary tumors (n = 55) and single disseminated tumor cells (n = 100) were analyzed by comparative genomic hybridization. Results Detection of cytokeratin-positive cells before surgery was the strongest independent risk factor for metastasis within 48 months (P < .001; relative risk [RR], 5.5; 95% CI, 2.4 to 12.9). In contrast, cytokeratin-positive cells detected 6 months to 10 years after radical prostatectomy were consistently present in bone marrow with a prevalence of approximately 20% but had no influence on disease outcome. Characteristic genotypes of cytokeratin-positive cells were selected at manifestation of metastasis. Conclusion Cytokeratin-positive cells in the bone marrow of prostate cancer patients are only prognostically relevant when detected before surgery. Because we could not identify significant genetic differences between pre- and postoperatively isolated tumor cells before manifestation of metastasis, we postulate the existence of perioperative stimuli that activate disseminated tumor cells. Patients with cytokeratin-positive cells in bone marrow before surgery may therefore benefit from adjuvant therapies.

scholarly journals Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer

The Prostate ◽  
2019 ◽  
Vol 79 (14) ◽  
pp. 1715-1727 ◽  
Author(s):  
Frank C. Cackowski ◽  
Yugang Wang ◽  
Joseph T. Decker ◽  
Christopher Sifuentes ◽  
Steven Weindorf ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Tumor Cells ◽  
Disseminated Tumor Cells ◽  
Localized Prostate Cancer

Significance of apoptotic and non-apoptotic disseminated tumor cells in the bone marrow of patients with clinically localized prostate cancer

The Prostate ◽  
2015 ◽  
Vol 75 (6) ◽  
pp. 637-645 ◽  
Author(s):  
Tilman Todenhöfer ◽  
Jörg Hennenlotter ◽  
Frank Faber ◽  
Diethelm Wallwiener ◽  
David Schilling ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Tumor Cells ◽  
Disseminated Tumor Cells ◽  
Localized Prostate Cancer

scholarly journals Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer

Oncotarget ◽  
2020 ◽  
Vol 11 (46) ◽  
pp. 4253-4265
Author(s):  
Erika Heninger ◽  
Nan Sethakorn ◽  
David Kosoff ◽  
Peiman Hematti ◽  
Morgan D. Kuczler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
High Risk ◽  
Bone Marrow Microenvironment ◽  
Localized Prostate Cancer ◽  
Immune Profiling
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