scholarly journals Survival correlation of immune response in human cancers

Oncotarget ◽  
2019 ◽  
Vol 10 (64) ◽  
pp. 6885-6897
Author(s):  
Yuexin Liu
Keyword(s):  
Immune Response ◽  
Human Cancers

scholarly journals Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Fengju Chen ◽  
Darshan S. Chandrashekar ◽  
Sooryanarayana Varambally ◽  
Chad J. Creighton
Keyword(s):  
Mass Spectrometry ◽  
Immune Response ◽  
T Cell Activation ◽  
Cell Activation ◽  
Molecular Subtypes ◽  
Tumor Stroma ◽  
Proteomic Profiling ◽  
Cancer Subtypes ◽  
Human Cancers ◽  
Pan Cancer

AbstractMass-spectrometry-based proteomic profiling of human cancers has the potential for pan-cancer analyses to identify molecular subtypes and associated pathway features that might be otherwise missed using transcriptomics. Here, we classify 532 cancers, representing six tissue-based types (breast, colon, ovarian, renal, uterine), into ten proteome-based, pan-cancer subtypes that cut across tumor lineages. The proteome-based subtypes are observable in external cancer proteomic datasets surveyed. Gene signatures of oncogenic or metabolic pathways can further distinguish between the subtypes. Two distinct subtypes both involve the immune system, one associated with the adaptive immune response and T-cell activation, and the other associated with the humoral immune response. Two additional subtypes each involve the tumor stroma, one of these including the collagen VI interacting network. Three additional proteome-based subtypes—respectively involving proteins related to Golgi apparatus, hemoglobin complex, and endoplasmic reticulum—were not reflected in previous transcriptomics analyses. A data portal is available at UALCAN website.

scholarly journals Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Roberta Santarelli ◽  
Marisa Granato ◽  
Alberto Faggioni ◽  
Mara Cirone
Keyword(s):  
Immune Response ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Immune Control ◽  
Antiviral Immune Response ◽  
Human Cancers ◽  
Autophagic Process ◽  
Epstein Barr ◽  
Kaposi’S Sarcoma Associated Herpesvirus

We summarized the most recent findings on the role of autophagy in antiviral immune response. We described how viruses have developed strategies to subvert the autophagic process. A particular attention has been given to Epstein-Barr and Kaposi’s sarcoma associated Herpesvirus, viruses studied for many years in our laboratory. These two viruses belong toγ-Herpesvirus subfamily and are associated with several human cancers. Besides the effects on the immune response, we have described how autophagy subversion by viruses may also concur to the enhancement of their replication and to viral tumorigenesis.

scholarly journals Papillomaviruses in Domestic Cats

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1664
Author(s):  
John S. Munday ◽  
Neroli A. Thomson
Keyword(s):  
Immune Response ◽  
Life Cycle ◽  
Animal Species ◽  
Domestic Cats ◽  
Cell Regulation ◽  
Domestic Species ◽  
Human Cancers

Papillomaviruses (PVs) are well established to cause hyperplastic papillomas (warts) in humans and animals. In addition, due to their ability to alter cell regulation, PVs are also recognized to cause approximately 5% of human cancers and these viruses have been associated with neoplasia in a number of animal species. In contrast to other domestic species, cats have traditionally been thought to less frequently develop disease due to PV infection. However, in the last 15 years, the number of viruses and the different lesions associated with PVs in cats have greatly expanded. In this review, the PV life cycle and the subsequent immune response is briefly discussed along with methods used to investigate a PV etiology of a lesion. The seven PV types that are currently known to infect cats are reviewed. The lesions that have been associated with PV infections in cats are then discussed and the review finishes with a brief discussion on the use of vaccines to prevent PV-induced disease in domestic cats.

scholarly journals Comprehensive Characterization And Clinical Relevance of CLEC4G Expression Across Human Cancers

2022 ◽  
Author(s):  
Yong Li ◽  
Huiqin Huang ◽  
Xiangli Ye ◽  
Xiaoping Li ◽  
Zhenghui Huang ◽  
...  
Keyword(s):  
Immune Response ◽  
Enrichment Analysis ◽  
Treg Cells ◽  
Renal Clear Cell Carcinoma ◽  
Human Cancers ◽  
Cancer Immunity ◽  
Cancer Types ◽  
Molecular Expression ◽  
Comprehensive Characterization

Abstract Liver and lymph node sinusoidal endothelial cell C-type lectin (CLEC4G) interacts with the surface glycoproteins of enveloped viruses and mediates immune evasion for viruses. Recent studies have indicated that the expression of CLEC4G affects the development and microenvironment of tumors. In the present study, we revealed comprehensive characterization of CLEC4G expression across human cancers. We first explored the effect of CLEC4G expression on overall survival (OS) across human cancers. High expression of CLEC4G was beneficial in lung adenocarcinoma (LUAD) and detrimental in kidney renal clear cell carcinoma (KIRC) and uveal melanoma (UVM) in terms of OS. Enrichment analysis of the 14 cancer-related signatures suggested that CLEC4G regulated tumor metastasis and immune response. Enrichment analysis of the immunophenotypes and cancer-immunity cycles indicated that CLEC4G was involved in regulation of macrophages and Treg cells, which affected tumor immune response. We also observed correlations between CLEC4G expression and checkpoint molecular expression in different cancer types. Taken together, the present study revealed the comprehensive characterization of CLEC4G expression across human cancers, predicting the roles of CLEC4G in the development and immune microenvironment of tumors.

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

Abstract #418: Effect of Testosterone (T) Replacement with a T-Gel or a New Oral T Formulation (Rextoro) on Selected Biomarkers of Endothelial Injury and Immune Response to Lipids

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Injury

THE ROLE OF TGFΒ IN HUMAN CANCERS

Pathology ◽  
2001 ◽  
Vol 33 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Shew-Fung Wong, Leslie C. Lai
Keyword(s):  
Human Cancers

Author response for "Diabetes alters immune response patterns to acute melioidosis in humans"

2019 ◽  
Author(s):  
Barbara Kronsteiner ◽  
Panjaporn Chaichana ◽  
Manutsanun Sumonwiriya ◽  
Kemajitra Jenjaroen ◽  
Fazle Rabbi Chowdhury ◽  
...  
Keyword(s):  
Immune Response ◽  
Author Response ◽  
Response Patterns
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