scholarly journals Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1

Oncotarget ◽  
2018 ◽  
Vol 9 (58) ◽  
pp. 31214-31230 ◽  
Author(s):  
William Hankey ◽  
Zhong Chen ◽  
Maxwell J. Bergman ◽  
Max O. Fernandez ◽  
Baris Hancioglu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals The Microphthalmia-Associated Transcription Factor Mitf Interacts with β-Catenin To Determine Target Gene Expression

2006 ◽  
Vol 26 (23) ◽  
pp. 8914-8927 ◽  
Author(s):  
Alexander Schepsky ◽  
Katja Bruser ◽  
Gunnar J. Gunnarsson ◽  
Jane Goodall ◽  
Jón H. Hallsson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Critical Role ◽  
Wnt Signaling Pathway ◽  
Feedback Mechanism ◽  
Canonical Wnt Signaling ◽  
Melanocyte Stem Cells ◽  
Canonical Wnt

ABSTRACT Commitment to the melanocyte lineage is characterized by the onset of expression of the microphthalmia-associated transcription factor (Mitf). This transcription factor plays a fundamental role in melanocyte development and maintenance and seems to be crucial for the survival of malignant melanocytes. Furthermore, Mitf has been shown to be involved in cell cycle regulation and to play important functions in self-renewal and maintenance of melanocyte stem cells. Although little is known about how Mitf regulates these various processes, one possibility is that Mitf interacts with other regulators. Here we show that Mitf can interact directly with β-catenin, the key mediator of the canonical Wnt signaling pathway. The Wnt signaling pathway plays a critical role in melanocyte development and is intimately involved in triggering melanocyte stem cell proliferation. Significantly, constitutive activation of this pathway is a feature of a number of cancers including malignant melanoma. Here we show that Mitf can redirect β-catenin transcriptional activity away from canonical Wnt signaling-regulated genes toward Mitf-specific target promoters to activate transcription. Thus, by a feedback mechanism, Mitf can diversify the output of canonical Wnt signaling to enhance the repertoire of genes regulated by β-catenin. Our results reveal a novel mechanism by which Wnt signaling and β-catenin activate gene expression, with significant implications for our understanding of both melanocyte development and melanoma.

scholarly journals To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

2016 ◽  
Vol 186 (5) ◽  
pp. 1140-1150 ◽  
Author(s):  
Dongwon Kim ◽  
M. Zulfiquer Hossain ◽  
Ashley Nieves ◽  
Lihong Gu ◽  
Tabetha S. Ratliff ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Skin Disease ◽  
Control Site ◽  
Canonical Wnt Signaling ◽  
Site Specific ◽  
Canonical Wnt

scholarly journals Time-Course Gene Expression Profiling Reveals a Novel Role of Non-Canonical WNT Signaling During Neural Induction

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Cindy Tzu-Ling Huang ◽  
Yunlong Tao ◽  
Jianfeng Lu ◽  
Jeffrey R. Jones ◽  
Lucas Fowler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Time Course ◽  
Neural Induction ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Gene expression in peripheral blood in treatment-free major depression

2020 ◽  
Vol 32 (3) ◽  
pp. 135-144
Author(s):  
Alfredo B. Cuellar-Barboza ◽  
Jorge A. Sánchez-Ruiz ◽  
Iram P. Rodriguez-Sanchez ◽  
Sarai González ◽  
Geovana Calvo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Target Genes ◽  
Wnt Signaling Pathway ◽  
Mexican Descent ◽  
Population Diversity ◽  
Canonical Wnt Signaling ◽  
Lineal Regression ◽  
Canonical Wnt

AbstractBackground:Peripheral gene expression of several molecular pathways has been studied in major depressive disorder (MDD) with promising results. We sought to investigate some of these genes in a treatment-free Latino sample of Mexican descent.Material and Methods:The sample consisted of 50 MDD treatment-free cases and 50 sex and age-matched controls. Gene expression of candidate genes of neuroplasticity (BDNF, p11, and VGF), inflammation (IL1A, IL1B, IL4, IL6, IL7, IL8, IL10, MIF, and TNFA), the canonical Wnt signaling pathway (TCF7L2, APC, and GSK3B), and mTOR, was compared in cases and controls. RNA was obtained from blood samples. We used bivariate analyses to compare subjects versus control mean mRNA quantification of target genes and lineal regression modelling to test for effects of age and body mass index on gene expression.Results:Most subjects were female (66%) with a mean age of 26.7 (SD 7.9) years. Only GSK3B was differentially expressed between cases and controls at a statistically significant level (p = 0.048). TCF7L-2 showed the highest number of correlations with MDD-related traits, yet these were modest in size.Discussion:GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.

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