scholarly journals Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice

Oncotarget ◽  
2018 ◽  
Vol 9 (27) ◽  
pp. 18760-18774 ◽  
Author(s):  
Raffaella Barbieri ◽  
Andrea Contestabile ◽  
Maria Grazia Ciardo ◽  
Nicola Forte ◽  
Antonella Marte ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Synapsin I ◽  
Adult Mice ◽  
Synapsin Ii

scholarly journals Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain

2020 ◽  
Vol 117 (41) ◽  
pp. 25818-25829
Author(s):  
Xinxing Wang ◽  
Hanxiao Liu ◽  
Johannes Morstein ◽  
Alexander J. E. Novak ◽  
Dirk Trauner ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Energy Homeostasis ◽  
Inhibitory Neuron ◽  
Hippocampal Neurogenesis ◽  
Adult Brain ◽  
Adult Hippocampal Neurogenesis ◽  
Neuron Activity ◽  
Adult Mice ◽  
Sphingosine 1 Phosphate ◽  
Underlying Mechanisms

Hippocampus-engaged behaviors stimulate neurogenesis in the adult dentate gyrus by largely unknown means. To explore the underlying mechanisms, we used tetrode recording to analyze neuronal activity in the dentate gyrus of freely moving adult mice during hippocampus-engaged contextual exploration. We found that exploration induced an overall sustained increase in inhibitory neuron activity that was concomitant with decreased excitatory neuron activity. A mathematical model based on energy homeostasis in the dentate gyrus showed that enhanced inhibition and decreased excitation resulted in a similar increase in neurogenesis to that observed experimentally. To mechanistically investigate this sustained inhibitory regulation, we performed metabolomic and lipidomic profiling of the hippocampus during exploration. We found sustainably increased signaling of sphingosine-1-phosphate, a bioactive metabolite, during exploration. Furthermore, we found that sphingosine-1-phosphate signaling through its receptor 2 increased interneuron activity and thus mediated exploration-induced neurogenesis. Taken together, our findings point to a behavior-metabolism circuit pathway through which experience regulates adult hippocampal neurogenesis.

scholarly journals Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

1998 ◽  
Vol 4 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Adriana Ferreira ◽  
Lih-Shen Chin ◽  
Lian Li ◽  
Lorene M. Lanier ◽  
Kenneth S. Kosik ◽  
...  
Keyword(s):  
Neuronal Development ◽  
Synapsin I ◽  
Synapsin Ii

NFIX-Mediated Inhibition of Neuroblast Branching Regulates Migration Within the Adult Mouse Ventricular–Subventricular Zone

2018 ◽  
Vol 29 (8) ◽  
pp. 3590-3604 ◽  
Author(s):  
Oressia Zalucki ◽  
Lachlan Harris ◽  
Tracey J Harvey ◽  
Danyon Harkins ◽  
Jocelyn Widagdo ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Adult Brain ◽  
Granule Cell Layer ◽  
Transcriptional Level ◽  
Olfactory Responses ◽  
Brain Functions ◽  
Neuroblast Migration ◽  
Adult Mice

Abstract Understanding the migration of newborn neurons within the brain presents a major challenge in contemporary biology. Neuronal migration is widespread within the developing brain but is also important within the adult brain. For instance, stem cells within the ventricular–subventricular zone (V-SVZ) and the subgranular zone of dentate gyrus of the adult rodent brain produce neuroblasts that migrate to the olfactory bulb and granule cell layer of the dentate gyrus, respectively, where they regulate key brain functions including innate olfactory responses, learning, and memory. Critically, our understanding of the factors mediating neuroblast migration remains limited. The transcription factor nuclear factor I X (NFIX) has previously been implicated in embryonic cortical development. Here, we employed conditional ablation of Nfix from the adult mouse brain and demonstrated that the removal of this gene from either neural stem and progenitor cells, or neuroblasts, within the V-SVZ culminated in neuroblast migration defects. Mechanistically, we identified aberrant neuroblast branching, due in part to increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), as a factor contributing to abnormal migration in Nfix-deficient adult mice. Collectively, these data provide new insights into how neuroblast migration is regulated at a transcriptional level within the adult brain.

scholarly journals Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice

2011 ◽  
Vol 108 (13) ◽  
pp. 5437-5442 ◽  
Author(s):  
B. H. Singer ◽  
A. E. Gamelli ◽  
C. L. Fuller ◽  
S. J. Temme ◽  
J. M. Parent ◽  
...  
Keyword(s):  
Young Adult ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Adult Mice ◽  
Term Potentiation

scholarly journals Genetic influence on neurogenesis in the dentate gyrus of adult mice

1997 ◽  
Vol 94 (19) ◽  
pp. 10409-10414 ◽  
Author(s):  
G. Kempermann ◽  
H. G. Kuhn ◽  
F. H. Gage
Keyword(s):  
Dentate Gyrus ◽  
Genetic Influence ◽  
Adult Mice

scholarly journals Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking FMRP

Hippocampus ◽  
2011 ◽  
Vol 22 (6) ◽  
pp. 1220-1224 ◽  
Author(s):  
Orly Lazarov ◽  
Michael P. Demars ◽  
Kai Da Tommy Zhao ◽  
Haroon M. Ali ◽  
Vanessa Grauzas ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Adult Mice

Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus

2008 ◽  
Vol 211 (2) ◽  
pp. 503-510 ◽  
Author(s):  
Rieko Muramatsu ◽  
Yuji Ikegaya ◽  
Norio Matsuki ◽  
Ryuta Koyama
Keyword(s):  
Status Epilepticus ◽  
Dentate Gyrus ◽  
Early Life ◽  
Granule Cells ◽  
Adult Mice
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