scholarly journals Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking FMRP

Hippocampus ◽  
2011 ◽  
Vol 22 (6) ◽  
pp. 1220-1224 ◽  
Author(s):  
Orly Lazarov ◽  
Michael P. Demars ◽  
Kai Da Tommy Zhao ◽  
Haroon M. Ali ◽  
Vanessa Grauzas ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Adult Mice

The fate of neural progenitor cells expressing astrocytic and radial glial markers in the postnatal rat dentate gyrus

2005 ◽  
Vol 22 (8) ◽  
pp. 1928-1941 ◽  
Author(s):  
Takashi Namba ◽  
Hideki Mochizuki ◽  
Masafumi Onodera ◽  
Yoshikuni Mizuno ◽  
Hideo Namiki ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Radial Glial

scholarly journals Capicua regulates the development of adult-born neurons in the hippocampus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Brenna Hourigan ◽  
Spencer D. Balay ◽  
Graydon Yee ◽  
Saloni Sharma ◽  
Qiumin Tan
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Proliferative Potential ◽  
Cell Pool ◽  
Adult Born Neurons

AbstractNew neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to expand the precursor cell pool and differentiate into neurons. Newly generated cells then undergo postmitotic maturation to migrate to their final destination and develop elaborate dendritic branching, which allows them to receive input signals. Little is known about factors that regulate neuronal differentiation, migration, and dendrite maturation during adult hippocampal neurogenesis. Here, we show that the transcriptional repressor protein capicua (CIC) exhibits dynamic expression in the adult dentate gyrus. Conditional deletion of Cic from the mouse dentate gyrus compromises the adult neural progenitor cell pool without altering their proliferative potential. We further demonstrate that the loss of Cic impedes neuronal lineage development and disrupts dendritic arborization and migration of adult-born neurons. Our study uncovers a previously unrecognized role of CIC in neurogenesis of the adult dentate gyrus.

scholarly journals Nigral dopaminergic neuron replenishment in adult mice through VE-cadherin-expressing neural progenitor cells

2017 ◽  
Vol 12 (11) ◽  
pp. 1865 ◽  
Author(s):  
BradE Morrison ◽  
AbirA Rahman ◽  
NathanK Lai ◽  
JoshuaE Albright ◽  
PaigeE Urquhart ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Dopaminergic Neuron ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Adult Mice

scholarly journals H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus

2022 ◽  
Vol 9 ◽  
Author(s):  
Miguel V. Guerra ◽  
Matías I. Cáceres ◽  
Andrea Herrera-Soto ◽  
Sebastián B. Arredondo ◽  
Manuel Varas-Godoy ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Neural Progenitor Cells ◽  
Adult Mouse ◽  
Histone H3 ◽  
Neural Progenitor ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Adult Hippocampus

In the dentate gyrus of the adult hippocampus new neurons are generated from neural precursor cells through different stages including proliferation and differentiation of neural progenitor cells and maturation of newborn neurons. These stages are controlled by the expression of specific transcription factors and epigenetic mechanisms, which together orchestrate the progression of the neurogenic process. However, little is known about the involvement of histone posttranslational modifications, a crucial epigenetic mechanism in embryonic neurogenesis that regulates fate commitment and neuronal differentiation. During embryonic development, the repressive modification trimethylation of histone H3 on lysine 9 (H3K9me3) contributes to the cellular identity of different cell-types. However, the role of this modification and its H3K9 methyltransferases has not been elucidated in adult hippocampal neurogenesis. We determined that during the stages of neurogenesis in the adult mouse dentate gyrus and in cultured adult hippocampal progenitors (AHPs), there was a dynamic change in the expression and distribution of H3K9me3, being enriched at early stages of the neurogenic process. A similar pattern was observed in the hippocampus for the dimethylation of histone H3 on lysine 9 (H3K9me2), another repressive modification. Among H3K9 methyltransferases, the enzymes Suv39h1 and Suv39h2 exhibited high levels of expression at early stages of neurogenesis and their expression decreased upon differentiation. Pharmacological inhibition of these enzymes by chaetocin in AHPs reduced H3K9me3 and concomitantly decreased neuronal differentiation while increasing proliferation. Moreover, Suv39h1 and Suv39h2 knockdown in newborn cells of the adult mouse dentate gyrus by retrovirus-mediated RNA interference impaired neuronal differentiation of progenitor cells. Our results indicate that H3K9me3 and H3K9 methyltransferases Suv39h1 and Suv39h2 are critically involved in the regulation of adult hippocampal neurogenesis by controlling the differentiation of neural progenitor cells.

Cytomegalovirus in the human dentate gyrus and its impact on neural progenitor cells: report of two cases

2017 ◽  
Vol 36 (09) ◽  
pp. 240-245 ◽  
Author(s):  
Ju-Yoon Yoon ◽  
Brett Danielson ◽  
Derek Mathis ◽  
Jason Karamchandani ◽  
David G. Munoz
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor

Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment

2017 ◽  
Vol 31 (10) ◽  
pp. 4347-4358 ◽  
Author(s):  
Shufang Feng ◽  
Tianyao Shi ◽  
Jiangxia Qiu ◽  
Haihong Yang ◽  
Yan Wu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor
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