scholarly journals MET amplification assessed using optimized FISH reporting criteria predicts early distant metastasis in patients with non-small cell lung cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (16) ◽  
pp. 12959-12970 ◽  
Author(s):  
Lianghua Fang ◽  
Hui Chen ◽  
Zhenya Tang ◽  
Neda Kalhor ◽  
Ching-Hua Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Met Amplification ◽  
Early Distant Metastasis

Thallium-201 SPECT in advanced non-small cell lung cancer: In relation with chemotherapeutic response, survival, distant metastasis and p53 status

2003 ◽  
Vol 17 (5) ◽  
pp. 369-374 ◽  
Author(s):  
Tevfik Fikret Çermik ◽  
Mahmut Yüksel ◽  
Celal Karlikaya ◽  
Latife Doĝanay ◽  
Mevlüt Türe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Small Cell ◽  
Thallium 201 ◽  
Small Cell Lung ◽  
Chemotherapeutic Response ◽  
P53 Status

scholarly journals Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer

2020 ◽  
Vol 21 (14) ◽  
pp. 4934
Author(s):  
Shuichi Sakamoto ◽  
Hiroyuki Inoue ◽  
Yasuko Kohda ◽  
Shun-ichi Ohba ◽  
Taketoshi Mizutani ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Transmembrane Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Orthotopic Model ◽  
Metastatic Tumors ◽  
Metastatic Sites

Small cell lung cancer (SCLC) is a severe malignancy associated with early and widespread metastasis. To study SCLC metastasis, we previously developed an orthotopic transplantation model using the human SCLC cell line DMS273. In the model, metastatic foci were found in distant tissues such as bone and the adrenal gland, similarly as observed in patients with SCLC. In this study, we evaluated the differentially expressed genes between orthotopic and metastatic tumors in the model. We isolated tumor cells from orthotopic and metastatic sites, and the tumor cell RNA was analyzed using DNA microarray analysis. We found that 19 genes in metastatic tumors were upregulated by more than 4-fold compared with their expression in orthotopic tumors. One of these genes encodes a transmembrane protein, interferon (IFN)-induced transmembrane protein 1 (IFITM1), and immunohistochemical analysis confirmed the higher expression of the protein in metastatic sites than in orthotopic sites. IFITM1 was also detected in some SCLC cell lines and lung tumors from patients with SCLC. The overexpression of IFITM1 in DMS273 cells increased their metastatic formation in the orthotopic model and in an experimental metastasis model. Conversely, the silencing of IFITM1 suppressed metastatic formation by DMS273 cells. We also found that IFITM1 overexpression promoted the metastatic formation of NCI-H69 human SCLC cells. These results demonstrate that IFITM1 promotes distant metastasis in xenograft models of human SCLC.

scholarly journals Assessment of surgical treatment for distant metastasis from completely resected non-small cell lung cancer

2007 ◽  
Vol 21 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Tohru Hasumi ◽  
Nobuyuki Sato ◽  
Shinichirou Ohta ◽  
Masami Sato ◽  
Chiaki Endo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surgical Treatment ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Small Cell ◽  
Small Cell Lung
Sign in / Sign up

Export Citation Format

Share Document