Thallium-201 SPECT in advanced non-small cell lung cancer: In relation with chemotherapeutic response, survival, distant metastasis and p53 status

2003 ◽  
Vol 17 (5) ◽  
pp. 369-374 ◽  
Author(s):  
Tevfik Fikret Çermik ◽  
Mahmut Yüksel ◽  
Celal Karlikaya ◽  
Latife Doĝanay ◽  
Mevlüt Türe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Small Cell ◽  
Thallium 201 ◽  
Small Cell Lung ◽  
Chemotherapeutic Response ◽  
P53 Status

FHIT and p53 Status and Response to Platinum-Based Treatment in Advanced Non-Small Cell Lung Cancer

2008 ◽  
Vol 8 (5) ◽  
pp. 342-348 ◽  
Author(s):  
D. Cortinovis ◽  
F. Andriani ◽  
A. Livio ◽  
A. Fabbri ◽  
F. Perrone ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
P53 Status

scholarly journals Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer

2020 ◽  
Vol 21 (14) ◽  
pp. 4934
Author(s):  
Shuichi Sakamoto ◽  
Hiroyuki Inoue ◽  
Yasuko Kohda ◽  
Shun-ichi Ohba ◽  
Taketoshi Mizutani ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Distant Metastasis ◽  
Transmembrane Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Orthotopic Model ◽  
Metastatic Tumors ◽  
Metastatic Sites

Small cell lung cancer (SCLC) is a severe malignancy associated with early and widespread metastasis. To study SCLC metastasis, we previously developed an orthotopic transplantation model using the human SCLC cell line DMS273. In the model, metastatic foci were found in distant tissues such as bone and the adrenal gland, similarly as observed in patients with SCLC. In this study, we evaluated the differentially expressed genes between orthotopic and metastatic tumors in the model. We isolated tumor cells from orthotopic and metastatic sites, and the tumor cell RNA was analyzed using DNA microarray analysis. We found that 19 genes in metastatic tumors were upregulated by more than 4-fold compared with their expression in orthotopic tumors. One of these genes encodes a transmembrane protein, interferon (IFN)-induced transmembrane protein 1 (IFITM1), and immunohistochemical analysis confirmed the higher expression of the protein in metastatic sites than in orthotopic sites. IFITM1 was also detected in some SCLC cell lines and lung tumors from patients with SCLC. The overexpression of IFITM1 in DMS273 cells increased their metastatic formation in the orthotopic model and in an experimental metastasis model. Conversely, the silencing of IFITM1 suppressed metastatic formation by DMS273 cells. We also found that IFITM1 overexpression promoted the metastatic formation of NCI-H69 human SCLC cells. These results demonstrate that IFITM1 promotes distant metastasis in xenograft models of human SCLC.

scholarly journals Role of KEAP1/NFE2L2 Mutations in the Chemotherapeutic Response of Patients with Non–Small Cell Lung Cancer

2019 ◽  
Vol 26 (1) ◽  
pp. 274-281 ◽  
Author(s):  
Youngtae Jeong ◽  
Jessica A. Hellyer ◽  
Henning Stehr ◽  
Ngoc T. Hoang ◽  
Xiaomin Niu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Chemotherapeutic Response
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