scholarly journals G protein beta 3(GNβ3) C825T polymorphism and irritable bowel syndrome susceptibility: an updated meta-analysis based on eleven case-control studies

Oncotarget ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 2770-2781 ◽  
Author(s):  
Dongbo Jiang ◽  
Dong Huang ◽  
Weiming Cai ◽  
Ting Li ◽  
Yan Wang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
G Protein ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
C825t Polymorphism ◽  
Irritable Bowel ◽  
Eleven Case

scholarly journals The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

2020 ◽  
Vol 17 (7) ◽  
pp. 2524
Author(s):  
Yun-A Kim ◽  
Yoon Jeong Cho ◽  
Sang Gyu Kwak
Keyword(s):  
Helicobacter Pylori ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
H Pylori ◽  
Irritable Bowel ◽  
The Relationship

The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case–control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93–1.29, I2: 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93–1.30, I2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.

scholarly journals Healthy Controls Are Not Appropriately Identified for Comparison to Irritable Bowel Syndrome in Case Control Studies

2011 ◽  
Vol 140 (5) ◽  
pp. S-799 ◽  
Author(s):  
Shireen Ghorbani ◽  
Amir Nejad ◽  
David Law ◽  
Kathleen Chua ◽  
Meridythe M. Amichai ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Case Control ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Irritable Bowel

scholarly journals Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mei Luo ◽  
Xiaojun Zhuang ◽  
Zhenyi Tian ◽  
Lishou Xiong
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Mean Differences ◽  
Irritable Bowel ◽  
Chain Fatty Acids

Abstract Background Short-chain fatty acids (SCFAs) and serotonin (5-hydroxytryptamine, 5-HT) may be associated with the pathogenesis of irritable bowel syndrome (IBS). There are some reports of alterations in SCFAs and 5-HT in IBS, but their results are inconsistent. We aimed to perform a meta-analysis to assess alterations in SCFAs and 5-HT in IBS patients and their potential role in the abnormal brain-gut-microbiota (BGM) axis. Methods Case–control studies detecting SCFAs and 5-HT in IBS patients were identified from PubMed, Web of Science, Cochrane Library, and Scopus databases to identify relevant articles up to September 2018. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) of SCFAs and 5-HT were calculated by REVIEW MANAGER 5.3 to evaluate the alterations of 5-HT and SCFAs in IBS. Results Five studies on SCFAs and 5 on 5-HT in IBS patients were included. As compared to healthy controls (HCs), the SMDs of 5-HT in IBS patients was 2.35 (95% CI 0.46–4.24) and the SMDs of total SCFAs, acetic acid, propionic acid, and butyric acid in IBS patients were − 0.01 (95% CI − 0.57–0.55), − 0.04 (95% CI − 0.55–0.47), 0.07 (95% CI − 0.45–0.60), and − 0.00 (95% CI − 0.49–0.49), respectively. Conclusions There was an increase in 5-HT in blood of IBS patients, indicating the increased 5-HT in blood may be involved in IBS pathogenesis. However, there were no significant differences in SCFAs in feces between IBS patients and HCs. But the study did not differentiate between subgroups of IBS. These findings might provide insight for future studies of the BGM axis in the pathogenesis of IBS. Mei Luo and Xiaojun Zhuang contributed equally to the writing of this article

scholarly journals A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset

2016 ◽  
Vol 46 (15) ◽  
pp. 3065-3080 ◽  
Author(s):  
A. Sibelli ◽  
T. Chalder ◽  
H. Everitt ◽  
P. Workman ◽  
S. Windgassen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Population Based ◽  
Self Report ◽  
Anxiety And Depression ◽  
Gastrointestinal Infection ◽  
Case Control Studies ◽  
Irritable Bowel

BackgroundIt is well established that people with irritable bowel syndrome (IBS) have higher levels of anxiety and depression compared with controls. However, the role of these as risk factors is less clearly established. The aims of this systematic review were to investigate: (1) whether anxiety and/or depression predict IBS onset; (2) the size of the relative risk (RR) of anxiety versus depression in IBS onset. Subgroup analyses explored if methodological factors affected the overall findings.MethodProspective cohort or case–control studies were included if they: (1) focused on the development of IBS in population-based or gastroenteritis cohorts; (2) explored the effects of anxiety and/or depression at baseline as predictors of IBS onset at a future point. In all, 11 studies were included of which eight recruited participants with a gastrointestinal infection. Meta-analyses were conducted.ResultsThe risk of developing IBS was double for anxiety cases at baseline compared with those who were not [RR 2.38, 95% confidence interval (CI) 1.58–3.60]. Similar results were found for depression (RR 2.06, 95% CI 1.44–2.96). Anxiety and depression seemed to play a stronger role in IBS onset in individuals with a gastrointestinal infection although this could be attributed to other differences in methodology, such as use of diagnostic interviews rather than self-report.ConclusionsThe findings suggest that self-reported anxiety and depression provide a twofold risk for IBS onset. There is less support for the role of anxiety or depressive disorder diagnosed using clinical interview. These findings may have implications for the development of interventions focused on IBS prevention and treatment.

scholarly journals Mast Cells in Irritable Bowel Syndrome: A Systematic Review

2019 ◽  
Vol 28 (4) ◽  
pp. 463-472 ◽  
Author(s):  
Luisa Krammer ◽  
Anna Sergeevna Sowa ◽  
Axel Lorentz
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Psychological Factors ◽  
Significant Positive Correlation ◽  
R Package ◽  
Case Control ◽  
Case Control Studies ◽  
Electronic Search ◽  
Associated Symptoms ◽  
Irritable Bowel

Background and Aims: As mast cells (MC) serve as a link between mucosal immune activity and the nervous system, it is likely they also play a role in the pathogenesis of irritable bowel syndrome (IBS). This connection might be an important factor in the development of IBS-related symptoms. Method: This overview comprises 36 case-control studies published from 2000 to 2018 that investigated MC in bowel biopsies of IBS patients and controls. The studies were selected from PubMed, EMBASE, Central, SemanticScholar by an electronic search, performed using RISMed R package. Results: Significantly increased mucosal MC counts/or density in IBS patients compared to controls was observed in 30 studies. Five studies reported no differences and only one of the studies found a decreased amount of MC in an IBS patient. Furthermore, 15 studies made a statement regarding the correlation between the amount of MC and IBS associated symptoms. A significant positive correlation between MC count and IBS-associated symptoms was found in six investigations. A negative correlation was not reported. Conclusion: The results support the idea that MC are involved in IBS pathophysiology as key players in the interplay between psychological factors and the frequency and severity of IBS symptoms.

A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome

2015 ◽  
Vol 27 (5) ◽  
pp. 717-727 ◽  
Author(s):  
B. Czogalla ◽  
S. Schmitteckert ◽  
L. A. Houghton ◽  
G. S. Sayuk ◽  
M. Camilleri ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Association Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Irritable Bowel ◽  
Control Association
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