A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome

2015 ◽  
Vol 27 (5) ◽  
pp. 717-727 ◽  
Author(s):  
B. Czogalla ◽  
S. Schmitteckert ◽  
L. A. Houghton ◽  
G. S. Sayuk ◽  
M. Camilleri ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Association Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Irritable Bowel ◽  
Control Association

scholarly journals Case-control association mapping without cases

2016 ◽  
Author(s):  
Jimmy Z Liu ◽  
Yaniv Erlich ◽  
Joseph K Pickrell
Keyword(s):  
Association Mapping ◽  
Complex Traits ◽  
Disease Risk ◽  
Association Studies ◽  
Meta Analysis ◽  
Large Population ◽  
Case Control ◽  
Genome Wide Association Studies ◽  
The Uk ◽  
Control Association

AbstractThe case-control association study is a powerful method for identifying genetic variants that influence disease risk. However, the collection of cases can be time-consuming and expensive; if a disease occurs late in life or is rapidly lethal, it may be more practical to identify family members of cases. Here, we show that replacing cases with their first-degree relatives enables genome-wide association studies by proxy (GWAX). In randomly-ascertained cohorts, this approach enables previously infeasible studies of diseases that are absent (or nearly absent) in the cohort. As an illustration, we performed GWAX of 12 common diseases in 116,196 individuals from the UK Biobank. By combining these results with published GWAS summary statistics in a meta-analysis, we replicated established risk loci and identified 17 newly associated risk loci: four in Alzheimer’s disease, eight in coronary artery disease, and five in type 2 diabetes. In addition to informing disease biology, our results demonstrate the utility of association mapping using family history of disease as a phenotype to be mapped. We anticipate that this approach will prove useful in future genetic studies of complex traits in large population cohorts.

scholarly journals The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

2020 ◽  
Vol 17 (7) ◽  
pp. 2524
Author(s):  
Yun-A Kim ◽  
Yoon Jeong Cho ◽  
Sang Gyu Kwak
Keyword(s):  
Helicobacter Pylori ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
H Pylori ◽  
Irritable Bowel ◽  
The Relationship

The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case–control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93–1.29, I2: 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93–1.30, I2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.

Sign in / Sign up

Export Citation Format

Share Document