scholarly journals Prognostic value of microRNA expression levels in pancreatic adenocarcinoma: a review of the literature

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 73345-73361 ◽  
Author(s):  
Patrick Wald ◽  
X. Shawn Liu ◽  
Cory Pettit ◽  
Mary Dillhoff ◽  
Andrei Manilchuk ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Prognostic Value ◽  
Microrna Expression ◽  
Review Of The Literature ◽  
Expression Levels

Measuring MicroRNA Expression Levels in Oncology: from Samples to Data Analysis

2013 ◽  
Vol 18 (4) ◽  
pp. 273-287 ◽  
Author(s):  
Loris De Cecco ◽  
Matteo Dugo ◽  
Silvana Canevari ◽  
Maria Grazia Daidone ◽  
Maurizio Callari
Keyword(s):  
Data Analysis ◽  
Microrna Expression ◽  
Expression Levels

The isoattenuating pancreatic adenocarcinoma: Review of the literature and critical analysis

2015 ◽  
Vol 24 (4) ◽  
pp. 322-328 ◽  
Author(s):  
K. Blouhos ◽  
K.A. Boulas ◽  
K. Tsalis ◽  
A. Hatzigeorgiadis
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Critical Analysis ◽  
Review Of The Literature

Comparison of microRNA expression levels between initial and recurrent glioblastoma specimens

2013 ◽  
Vol 112 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Aysegül Ilhan-Mutlu ◽  
Adelheid Wöhrer ◽  
Anna Sophie Berghoff ◽  
Georg Widhalm ◽  
Christine Marosi ◽  
...  
Keyword(s):  
Recurrent Glioblastoma ◽  
Microrna Expression ◽  
Expression Levels

scholarly journals The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chenghao Zhang ◽  
Xiaolei Ren ◽  
Jieyu He ◽  
Wanchun Wang ◽  
Chao Tu ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Clinicopathological Features ◽  
Survival Outcomes ◽  
Tumor Type ◽  
Free Survival ◽  
Expression Levels ◽  
Human Cancers ◽  
Tcga Dataset

Abstract Background Cancer has been a worldwide health problem with a high risk of morbidity and mortality, however ideal biomarkers for effective screening and diagnosis of cancer patients are still lacking. Small nucleolar RNA host gene 16 (SNHG16) is newly identified lncRNA with abnormal expression in several human malignancies. However, its prognostic value remains controversial. This meta-analysis aimed to synthesize available data to clarify the association between SNHG16 expression levels and clinical prognosis value in multiple cancers. Methods Extensive literature retrieval was conducted to identify eligible studies, and data regarding SNHG16 expression levels on survival outcomes and clinicopathological features were extracted and pooled for calculation of the hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Forest plots were applied to show the association between SNHG16 expression and survival prognosis. Additionally, The Cancer Genome Atlas (TCGA) dataset was screened and extracted for validation of the results in this meta-analysis. Results A total of eight studies comprising 568 patients were included in the final meta-analysis according to the inclusion and exclusion criteria. In the pooled analysis, high SNHG16 expression significantly predicted worse overall survival (OS) in various cancers (HR = 1.87, 95% CI 1.54–2.26, P < 0.001), and recurrence-free survival (RFS) in bladder cancer (HR = 1.68, 95% CI 1.01–2.79, P = 0.045). Meanwhile, stratified analyses revealed that the survival analysis method, tumor type, sample size, and cut-off value did not alter the predictive value of SNHG16 for OS in cancer patients. In addition, compared to the low SNHG16 expression group, patients with high SNHG16 expression were more prone to worse clinicopathological features, such as larger tumor size, advanced clinical stage, lymph node metastasis (LNM) and distant metastasis (DM). Exploration of TCGA dataset further validated that the upregulated SNHG16 expression predicted unfavorable OS and disease-free survival (DFS) in cancer patients. Conclusions The present study implicated that aberrant expression of lncRNA SNHG16 was strongly associated with clinical survival outcomes in various cancers, and therefore might serve as a promising biomarker for predicting prognosis of human cancers.

Can balneotherapy modify microRNA expression levels in osteoarthritis? A comparative study in patients with knee osteoarthritis

2017 ◽  
Vol 61 (12) ◽  
pp. 2153-2158 ◽  
Author(s):  
C. Giannitti ◽  
A. De Palma ◽  
N. A. Pascarelli ◽  
S. Cheleschi ◽  
N. Giordano ◽  
...  
Keyword(s):  
Comparative Study ◽  
Knee Osteoarthritis ◽  
Microrna Expression ◽  
Expression Levels

scholarly journals Intrasplenic Pancreatic Pseudocyst after Chemoradiation of a Pancreatic Adenocarcinoma Mimicking Progressive Disease: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Thomas Benter ◽  
Oliver Roehr ◽  
Lutz Moser ◽  
Philipp Kiewe ◽  
Leopold Hentschel ◽  
...  
Keyword(s):  
Case Report ◽  
Pancreatic Adenocarcinoma ◽  
Pancreatic Pseudocyst ◽  
Progressive Disease ◽  
Rare Complication ◽  
Locally Advanced ◽  
Review Of The Literature ◽  
Locally Advanced Pancreatic Adenocarcinoma ◽  
Advanced Pancreatic Adenocarcinoma

Chemoradiation is one of the therapeutic options in palliative treatment of locally advanced pancreatic adenocarcinoma, with a well-known safety profile. In this case report, we describe the treatment-related occurrence of an intrasplenic pancreatic pseudocyst which was successfully removed by gastrocystic drainage. This rare complication should be considered in the follow-up and clinical management of patients, particularly if left-sided complaints occur.

Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma

2013 ◽  
Vol 19 (17) ◽  
pp. 4780-4791 ◽  
Author(s):  
Rongrong Wei ◽  
Guo-Liang Huang ◽  
Mei-Yin Zhang ◽  
Bin-Kui Li ◽  
Hui-Zhong Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Microrna Expression
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