scholarly journals Prognostic and predictive value of metastatic lymph node ratio in stage III gastric cancer after D2 nodal dissection

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 70841-70846 ◽  
Author(s):  
Yinbo Chen ◽  
Cong Li ◽  
Yian Du ◽  
Qi Xu ◽  
Jieer Ying ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Predictive Value ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Stage Iii ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Nodal Dissection

Metastatic lymph node ratio as an independent prognostic factor in stage III gastric cancer after D2 nodal dissection.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 738-738
Author(s):  
Jieer Ying ◽  
Cong Li ◽  
Yigong Zhang ◽  
Qi Xu
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Stage Iii ◽  
High Group ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Group 1

738 Background: The aim of this study was to evaluate the prognostic impact of metastatic lymph node ratio (MLR) in stage III gastric cancer after D2 dissection, and to assess the value of MLR for adjuvant chemotherapy. Methods: A total of 87 patients who underwent radical resection with D2 lymphadenectomy between December 2007 and March 2014 was enrolled in this study. Survival was determined by Kaplan-Meier method and survival curves were assessed by log-rank test. Multivariate analysis was performed using the Cox proportional hazards model. Results: The median age of patients was 60 (range:21 to 83) with a male to female ratio of 2. 83 patients have undergone total gastrectomy (95.4%) and 4 subtotal gastrectomy (4.6%). 57 patients received chemotherapy, including 24 neoadjuvant chemotherapy and 33 adjuvant chemotherapy. All chemotherapy regimens have contained Flouropyrimidines (5-FU or capecitabine). There were only 5 patients received single-agent 5-FU or capecitabine as chemotherapy regimen, while 52 patients received combined-chemotherapy. The median total retrieved lymph node was 35 (range:10 to 104) and the median metastatic lymph nodes was 8 (range: 0 to 71). MLR was classified into 4 groups as follows: Group 1(MLR = 0), Group 2(MLR < 0.1), Group 3(MLR = 0.1-0.25), Group 4(MLR > 0.25). After a median follow-up of 28 months, the median PFS of group 1-4 was 37.1m, 35.9m, 31.5m and 16.9m, respectively (p = 0.025). The median PFS was significantly different in subgroups: 39.2m in low group (MLR < 0.25) with adjuvant chemotherapy, 36.4m in low group without chemotherapy, 17.2m in high group (MLR > 0.25) with chemotherapy and 11.5m in high group without chemotherapy (p = 0.012). The MLR was retained as an independent prognostic factor in multivariable analysis. Conclusions: After R0 resection with D2 lymphadenectomy for stage III gastric cancer, MLR can be a more effective and prognostic indicator. Patients with high MLR may most benefit from adjuvant treatments.

Prognostic Significance of the Metastatic Lymph Node Ratio in Gastric Cancer Patients

2009 ◽  
Vol 33 (11) ◽  
pp. 2378-2382 ◽  
Author(s):  
Naoto Fukuda ◽  
Yasuyuki Sugiyama ◽  
Akira Midorikawa ◽  
Hiroyuki Mushiake
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Gastric Cancer Patients

Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy

2019 ◽  
Vol 42 (4) ◽  
pp. 209-216 ◽  
Author(s):  
Ahmet Bilici ◽  
Fatih Selcukbiricik ◽  
Mesut Seker ◽  
Basak B. Oven ◽  
Omer Fatih Olmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Curative Gastrectomy ◽  
Metastatic Lymph ◽  
Node Ratio

Metastatic Lymph Node Ratio: A New Staging System for Gastric Cancer

2009 ◽  
Vol 33 (10) ◽  
pp. 2106-2111 ◽  
Author(s):  
Roberto Persiani ◽  
Stefano Rausei ◽  
Vincenzo Antonacci ◽  
Alberto Biondi ◽  
Francesco Casella ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Staging System ◽  
Metastatic Lymph ◽  
Node Ratio
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