scholarly journals Diffusion-kurtosis imaging predicts early radiotherapy response in nasopharyngeal carcinoma patients

Oncotarget ◽  
2017 ◽  
Vol 8 (39) ◽  
pp. 66128-66136 ◽  
Author(s):  
Gang Wu ◽  
Meng-Meng Li ◽  
Feng Chen ◽  
Shao-Ming Lin ◽  
Kai Yang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Diffusion Kurtosis Imaging ◽  
Diffusion Kurtosis

scholarly journals Early Stage Markers of Late Delayed Neurocognitive Decline Using Diffusion Kurtosis Imaging of Temporal Lobe in Nasopharyngeal Carcinoma Patients

2020 ◽  
Vol 11 (20) ◽  
pp. 6168-6177
Author(s):  
Gang Wu ◽  
Shi-shi Luo ◽  
Priya S Balasubramanian ◽  
Gan-mian Dai ◽  
Rui-rui Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Early Stage ◽  
Diffusion Kurtosis Imaging ◽  
Diffusion Kurtosis ◽  
Neurocognitive Decline

Diffusion kurtosis imaging and tumour microstructure for monitoring response to radiotherapy in human nasopharyngeal carcinoma xenografts

2020 ◽  
Vol 50 (5) ◽  
pp. 548-555
Author(s):  
Xiang Zheng ◽  
Yunbin Chen ◽  
Dechun Zheng ◽  
Youping Xiao ◽  
Jiayou Chen ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Nude Mice ◽  
Tumour Size ◽  
Diffusion Kurtosis Imaging ◽  
X Ray ◽  
Human Nasopharyngeal Carcinoma ◽  
Xenograft Models ◽  
D Values ◽  
Diffusion Kurtosis ◽  
Fractional Irradiation

Abstract Objective To investigate the correlations and feasibility of diffusion kurtosis imaging (DKI) parameters and tumour histopathology after radiotherapy in human nasopharyngeal carcinoma (NPC) xenografts on nude mice. Materials and Methods Seventy-two nude mice were used for the construction of CNE-1 (radio-insensitive) and CNE-2 (radio-sensitive) NPC xenograft models, followed by fraction irradiation at different doses of X-ray. The nude mice were randomly divided into six groups in each cell line models according to the dose of X-ray they have received and with six mice in each group. DKI scan was performed after radiation. DKI parameters, tumour histopathology and AQP-1 biomarkers were detected. One-way ANOVA and Pearson’s correlation analysis were used in statistical analysis. Results In CNE-1 and CNE-2 NPC xenografts, D values were increased (P < 0.01 and P < 0.001), while K values (P < 0.01 and P < 0.001) and tumour size (P < 0.001 and P < 0.001) were reduced during fraction irradiation. Additionally, cell density (CD) and AQP-1 expressions were decreased, and necrosis ratio (NR) was increased in CNE-2 xenografts after fraction irradiation (P < 0.001). The changes in D values were negatively correlated with tumour size (r = −0.856, P < 0.001), CD (r = −0.918, P < 0.001), AQP-1 mRNA (r = −0.856, P < 0.001) and protein (r = −0.381, P = 0.022) expressions while positively correlated with NR (r = 0.908, P < 0.001) in CNE-2 xenografts. The changes in K values were positively correlated with tumour size (r = 0.964, P < 0.001), CD (r = 0.888, P < 0.001), AQP-1 mRNA (r = 0.955, P < 0.001) and protein (r = 0.330, P = 0.049) expression levels while negatively correlated with NR (r = −0.930, P < 0.001). However, in CNE-1 xenografts, there were no correlation between DKI parameters and the expression of AQP-1. Conclusion Changes in D and K parameters after fractional irradiation are closely related with NPC cellular and pathological characteristics, especially size reduction and necrosis induction. These parameters exhibit potential abilities of monitoring the response to fractional irradiation in radio-sensitive NPC xenografts.

Sign in / Sign up

Export Citation Format

Share Document