scholarly journals MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 70550-70563 ◽  
Author(s):  
Jie Peng ◽  
Yinghui Wu ◽  
Zhao Deng ◽  
Yuanfei Zhou ◽  
Tongxing Song ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
White Adipose Tissue ◽  
Sirtuin 1 ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals Erythropoietin Signaling: A Novel Regulator of White Adipose Tissue Inflammation During Diet-Induced Obesity

Diabetes ◽  
2014 ◽  
Vol 63 (7) ◽  
pp. 2415-2431 ◽  
Author(s):  
M. Alnaeeli ◽  
B. M. Raaka ◽  
O. Gavrilova ◽  
R. Teng ◽  
T. Chanturiya ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Diet Induced Obesity

scholarly journals Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice

2018 ◽  
Vol 315 (4) ◽  
pp. E676-E693 ◽  
Author(s):  
Valentina Caracciolo ◽  
Jeanette Young ◽  
Donna Gonzales ◽  
Yingchun Ni ◽  
Stephen J. Flowers ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Mrna Expression ◽  
Zinc Finger Protein ◽  
Inflammatory Responses ◽  
Adipose Tissue Inflammation ◽  
Obese Mice ◽  
Tissue Inflammation ◽  
Mrna Binding

Obesity is associated with adipose tissue inflammation that contributes to insulin resistance. Zinc finger protein 36 (Zfp36) is an mRNA-binding protein that reduces inflammation by binding to cytokine transcripts and promoting their degradation. We hypothesized that myeloid-specific deficiency of Zfp36 would lead to increased adipose tissue inflammation and reduced insulin sensitivity in diet-induced obese mice. As expected, wild-type (Control) mice became obese and diabetic on a high-fat diet, and obese mice with myeloid-specific loss of Zfp36 [knockout (KO)] demonstrated increased adipose tissue and liver cytokine mRNA expression compared with Control mice. Unexpectedly, in glucose tolerance testing and hyperinsulinemic-euglycemic clamp studies, myeloid Zfp36 KO mice demonstrated improved insulin sensitivity compared with Control mice. Obese KO and Control mice had similar macrophage infiltration of the adipose depots and similar peripheral cytokine levels, but lean and obese KO mice demonstrated increased Kupffer cell (KC; the hepatic macrophage)-expressed Mac2 compared with lean Control mice. Insulin resistance in obese Control mice was associated with enhanced Zfp36 expression in KCs. Compared with Control mice, KO mice demonstrated increased hepatic mRNA expression of a multitude of classical (M1) inflammatory cytokines/chemokines, and this M1-inflammatory hepatic milieu was associated with enhanced nuclear localization of IKKβ and the p65 subunit of NF-κB. Our data confirm the important role of innate immune cells in regulating hepatic insulin sensitivity and lipid metabolism, challenge-prevailing models in which M1 inflammatory responses predict insulin resistance, and indicate that myeloid-expressed Zfp36 modulates the response to insulin in mice.

Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression

Obesity ◽  
2018 ◽  
Vol 26 (3) ◽  
pp. 547-558 ◽  
Author(s):  
Zhuolun Song ◽  
Xavier Revelo ◽  
Weijuan Shao ◽  
Lili Tian ◽  
Kejing Zeng ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
White Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Brown Adipose ◽  
Ucp1 Expression

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets

2017 ◽  
Vol 126 ◽  
pp. 84-91 ◽  
Author(s):  
Katherine Suitor ◽  
George W. Payne ◽  
Ousseynou Sarr ◽  
Salma Abdelmagid ◽  
Manabu T. Nakamura ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Arachidonic Acid ◽  
Linoleic Acid ◽  
White Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Low Fat ◽  
Tissue Inflammation ◽  
Fat Diets

scholarly journals miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity

Diabetes ◽  
2018 ◽  
Vol 67 (12) ◽  
pp. 2541-2553 ◽  
Author(s):  
Eun-Hee Koh ◽  
Natasha Chernis ◽  
Pradip K. Saha ◽  
Liuling Xiao ◽  
David A. Bader ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Improve Insulin Sensitivity ◽  
Tissue Inflammation ◽  
Subcutaneous Adipose

scholarly journals Fibrosis as a Cause or a Consequence of White Adipose Tissue Inflammation in Obesity

2012 ◽  
Vol 2 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Sophie Reggio ◽  
Vanessa Pellegrinelli ◽  
Karine Clément ◽  
Joan Tordjman
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation
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