scholarly journals Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Petra Mulder ◽  
Martine C. Morrison ◽  
Lars Verschuren ◽  
Wen Liang ◽  
J. Hajo van Bockel ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Liver Disease ◽  
Fatty Liver ◽  
White Adipose Tissue ◽  
Fatty Liver Disease ◽  
Adipose Tissue Inflammation ◽  
Alcoholic Fatty Liver ◽  
Tissue Inflammation ◽  
Deficient Mice ◽  
Alcoholic Fatty Liver Disease

scholarly journals MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease

2016 ◽  
Vol 292 (4) ◽  
pp. 1267-1287 ◽  
Author(s):  
Anthony Virtue ◽  
Candice Johnson ◽  
Jahaira Lopez-Pastraña ◽  
Ying Shao ◽  
Hangfei Fu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Liver Disease ◽  
Fatty Liver ◽  
White Adipose Tissue ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals High-fructose feeding does not induce steatosis or non-alcoholic fatty liver disease in pigs

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nikolaj H. Schmidt ◽  
Pia Svendsen ◽  
Julián Albarrán-Juárez ◽  
Søren K. Moestrup ◽  
Jacob Fog Bentzon
Keyword(s):  
Adipose Tissue ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Histopathological Examination ◽  
De Novo Lipogenesis ◽  
Large Animal ◽  
Alcoholic Fatty Liver ◽  
High Fructose ◽  
Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition that has been linked to high-fructose corn syrup consumption with induction of hepatic de novo lipogenesis (DNL) as the suggested central mechanism. Feeding diets very high in fructose (> 60%) rapidly induce several features of NAFLD in rodents, but similar diets have not yet been applied in larger animals, such as pigs. With the aim to develop a large animal NAFLD model, we analysed the effects of feeding a high-fructose (HF, 60% w/w) diet for four weeks to castrated male Danish Landrace-York-Duroc pigs. HF feeding upregulated expression of hepatic DNL proteins, but levels were low compared with adipose tissue. No steatosis or hepatocellular ballooning was seen on histopathological examination, and plasma levels of transaminases were similar between groups. Inflammatory infiltrates and the amount of connective tissue was slightly elevated in liver sections from fructose-fed pigs, which was corroborated by up-regulation of macrophage marker expression in liver homogenates. Supported by RNA-profiling, quantitative protein analysis, histopathological examination, and biochemistry, our data suggest that pigs, contrary to rodents and humans, are protected against fructose-induced steatosis by relying on adipose tissue rather than liver for DNL.

737 Circulating and adipose tissue expression of visfatin in non-alcoholic fatty liver disease

2006 ◽  
Vol 44 ◽  
pp. S263-S264
Author(s):  
G. Soardol ◽  
C. Pagano ◽  
D. Donnini ◽  
C. Pilone ◽  
L. Domenis ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tissue Expression ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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