scholarly journals Prognostic value of the long noncoding RNA HOTTIP in human cancers

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 59563-59569 ◽  
Author(s):  
Wei Li ◽  
Na Li ◽  
Xinmei Kang ◽  
Ke Shi ◽  
Qiong Chen
2020 ◽  
Vol 66 (08/2020) ◽  
Author(s):  
Yugang Ge ◽  
Liyi Yang ◽  
Xin Chen* ◽  
Hailin Shan ◽  
Ying Su ◽  
...  

2019 ◽  
Vol 10 (11) ◽  
pp. 2386-2396 ◽  
Author(s):  
Yu Zhou ◽  
Rui Wang ◽  
Tian Xu ◽  
Ping Xie ◽  
Yun Zhang ◽  
...  

Medicine ◽  
2020 ◽  
Vol 99 (30) ◽  
pp. e21324
Author(s):  
Houyu Duan ◽  
Xiang Ding ◽  
Hesheng Luo

2017 ◽  
Vol 468 ◽  
pp. 10-16 ◽  
Author(s):  
Yang-Hua Fan ◽  
Chen-xing Ji ◽  
Bing Xu ◽  
Heng-yi Fan ◽  
Zu-jue Cheng ◽  
...  

2020 ◽  
Author(s):  
Yongfeng Li ◽  
Xinmiao Rui ◽  
Daobao Chen ◽  
Haojun Xuan ◽  
Hongjian Yang ◽  
...  

Abstract Background: Long noncoding RNA small nucleolar RNA host gene 20 (SNHG20) is a novel oncogene and dysregulated in a variety of human cancers. It has been revealed to be associated with the clinicopathological features and prognosis. However, the prognostic value of SNHG20 in various cancers remains unclear. Therefore, we performed this meta-analysis to evaluate the relationship between SNHG20 expression and clinical outcomes in human cancers.Methods: Comprehensive literature search was performed in PubMed, Web of Science, CNKI and Wangfang databases, and eligible studies were obtained according to the inclusion and exclusion criteria. The pooled hazard ratios (HRs) and odds ratios (ORs) were applied to assess the clinical value of SNHG20 expression for overall survival (OS) and clinicopathological features.Results: A total of 16 articles including 1190 cancer patients were included in the study. The pooled results demonstrated that evaluated SNHG20 expression was positively related to a poorer OS of cancers (HR=2.36, 95%CI: 1.85-2.87, P<0.001). Subgroup analysis revealed that SNHG20 overexpression was closely related to the low OS of patients with the digestive system cancer (HR=2.92, 95%CI: 1.96-3.88, P<0.001), sample size >80 (HR=2.42, 95%CI: 1.69-3.14, P<0.001), direct HR estimation method (HR=2.65, 95%CI: 1.78-3.52, P<0.001), and median ratio as cut-off value (HR=2.21, 95%CI: 1.60-2.83, P<0.001). In addition, the pooled data also showed that SNHG20 was positively linked to lymph node metastasis (LNM) (OR=1.65, 95%CI: 1.21-2.26, P=0.002), distant metastasis (DM) (OR=1.76, 95%CI: 1.10-2.83, P=0.02), and advanced TNM stage (OR=1.79, 95%CI: 1.34-2.39, P<0.001). Moreover, the results of the trim and fill analysis confirmed the reliability of our finding. Conclusions: Upregulation of SNHG20 was associated with advanced TNM stage, worse LNM and DM, and shorter OS, suggesting that SNHG20 may serve as a biomarker for prognosis and clinicopathological characteristics in human cancers.


Oncotarget ◽  
2017 ◽  
Vol 8 (48) ◽  
pp. 84497-84505 ◽  
Author(s):  
Dan Dong ◽  
Zhongyi Mu ◽  
Wei Wang ◽  
Na Xin ◽  
Xiaowen Song ◽  
...  

2019 ◽  
Vol 120 (11) ◽  
pp. 18599-18599 ◽  
Author(s):  
Maryam Moradi Binabaj ◽  
Amirhossein Bahreyni ◽  
Majid Khazaei ◽  
Amir Avan ◽  
Seyed Mahdi Hassanian

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