scholarly journals Can we consider discontinuation of hypomethylating agents in patients with myelodysplastic syndrome : a retrospective study from The Korean Society of Hematology AML/MDS Working Party

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79414-79424
Author(s):  
Da Jung Kim ◽  
Ho Sup Lee ◽  
Joon-Ho Moon ◽  
Sang Kyun Sohn ◽  
Hyeoung Joon Kim ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Myelodysplastic Syndrome ◽  
Working Party ◽  
Hypomethylating Agents ◽  
Korean Society

scholarly journals Demethylation and upregulation of an oncogene post hypomethylating treatment

2020 ◽  
Author(s):  
Yao-Chung Liu ◽  
Emiliano Fabiani ◽  
Junsu Kwon ◽  
Chong Gao ◽  
Giulia Falconi ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Cell Lines ◽  
Prognostic Value ◽  
Leukemic Cell ◽  
Hypomethylating Agents ◽  
Poor Outcome ◽  
Leukemic Cell Lines ◽  
The Relationship

While hypomethylating agents (HMA) are currently used to treat myelodysplastic syndrome (MDS) patients, their effects on reactivation and/or upregulation of oncogenes have not been previously described. SALL4 is a known oncogene that plays an important role in MDS. In this study, we examined the relationship between SALL4 methylation and expression, and evaluated changes of SALL4 expression and their prognostic value in MDS patients undergoing HMA treatment. In no/low-SALL4 expressing leukemic cell lines, we identified that demethylation of a critical CpG region was associated with increased SALL4 expression, and HMA treatment led to demethylation of this region and upregulation of SALL4. In MDS patients, we observed SALL4 upregulation after four cycles of azacytidine (AZA) treatment in 40% of the cases. Significantly, patients in the responder group with SALL4 upregulation had the worst outcome. This is the first study focusing on demethylation and upregulation of an oncogene after HMA treatment. Our data indicate that MDS patients receiving HMA treatment should be monitored for upregulation of oncogenes such as SALL4 for poor outcome.

scholarly journals Hereditary hemolytic anemia in Korea from 2007 to 2011: A study by the Korean Hereditary Hemolytic Anemia Working Party of the Korean Society of Hematology

2013 ◽  
Vol 48 (3) ◽  
pp. 211 ◽  
Author(s):  
Eun Sil Park ◽  
Hye Lim Jung ◽  
Hee-Jin Kim ◽  
Sung Sup Park ◽  
Soon Hwan Bae ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Working Party ◽  
Korean Society

scholarly journals Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology

2019 ◽  
Vol 54 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Young Kyung Lee ◽  
Hee-Jin Kim ◽  
Kyunghoon Lee ◽  
Sang Hyuk Park ◽  
Sang Hoon Song ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Recent Progress ◽  
Working Party ◽  
Laboratory Diagnosis ◽  
Korean Society ◽  
Cell Disorder
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