scholarly journals Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/suppressor phenotype

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 58003-58020 ◽  
Author(s):  
Estefanía Prochetto ◽  
Carolina Roldán ◽  
Iván A. Bontempi ◽  
Daiana Bertona ◽  
Luz Peverengo ◽  
...  
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Vaccine Candidate ◽  
Effector Immune Response ◽  
Cruzi Infection

Dynamics of T Cells Repertoire During Trypanosoma cruzi Infection and its Post-Treatment Modulation

2019 ◽  
Vol 26 (36) ◽  
pp. 6519-6543 ◽  
Author(s):  
Adriana Egui ◽  
Paola Lasso ◽  
Elena Pérez-Antón ◽  
M. Carmen Thomas ◽  
Manuel Carlos López
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Cardiac Tissue ◽  
Acute Infection ◽  
Clinical Status ◽  
Chronic Phase ◽  
Parasite Load ◽  
Chronic Patients ◽  
Cruzi Infection

Chagas disease courses with different clinical phases and has a variable clinical presentation and progression. The acute infection phase mostly exhibits a non-specific symptomatology. In the absence of treatment, the acute phase is followed by a chronic phase, which is initially asymptomatic. This chronic asymptomatic phase of the disease is characterized by a fragile balance between the host’s immune response and the parasite replication. The loss of this balance is crucial for the progression of the sickness. The virulence and tropism of the T. cruzi infecting strain together to the inflammation processes in the cardiac tissue are the main factors for the establishment and severity of the cardiomyopathy. The efficacy of treatment in chronic Chagas disease patients is controversial. However, several studies carried out in chronic patients demonstrated that antiparasitic treatment reduces parasite load in the bloodstream and leads to an improvement in the immune response against the Trypanosoma cruzi parasite. The present review is mainly focused on the cellular patterns associated to the clinical status and the evolution of the disease in chronic patients, as well as the effectiveness of the treatment related to T. cruzi infection control. Therefore, an emphasis is placed on the dynamics of specific-antigens T cell subpopulations, their memory and activation phenotypes, their functionality and their contribution to pathogenesis or disease control, as well as their association with risk of congenital transmission of the parasite.

scholarly journals Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico

2018 ◽  
Vol 12 (1) ◽  
pp. e0006240 ◽  
Author(s):  
Liliana E. Villanueva-Lizama ◽  
Julio V. Cruz-Chan ◽  
Amarú del C. Aguilar-Cetina ◽  
Luis F. Herrera-Sanchez ◽  
Jose M. Rodriguez-Perez ◽  
...  
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Vaccine Candidate ◽  
Chronic Patients ◽  
Recall Memory ◽  
Memory Immune Response

SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction

2021 ◽  
pp. 108913
Author(s):  
Paulo Gaio ◽  
Melisa Gualdrón-López ◽  
Allysson Cramer ◽  
Lisia Esper ◽  
José Evaldo Rodrigues de Menezes Filho ◽  
...  
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Cardiac Dysfunction ◽  
Hematopoietic Cells ◽  
Cruzi Infection

Immune response, nitric oxide, autonomic dysfunction and stroke: a puzzling linkage on Trypanosoma cruzi infection

2002 ◽  
Vol 58 (5) ◽  
pp. 374-377 ◽  
Author(s):  
N.X. Pinto ◽  
M.A. Torres-Hillera ◽  
E. Mendoza ◽  
F.E. León-Sarmiento
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Autonomic Dysfunction ◽  
Cruzi Infection

CTLA-4 regulates the murine immune response to Trypanosoma cruzi infection

2004 ◽  
Vol 26 (1) ◽  
pp. 19-28 ◽  
Author(s):  
S. E. B. Graefe ◽  
T. Jacobs ◽  
U. Wachter ◽  
B. M. Broker ◽  
B. Fleischer
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Cruzi Infection
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