scholarly journals Prognostic value and preoperative predictors of microvascular invasion in solitary hepatocellular carcinoma ≤ 5 cm without macrovascular invasion

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 61203-61214 ◽  
Author(s):  
Hui Zhao ◽  
Ye Hua ◽  
Zhihua Lu ◽  
Shen Gu ◽  
Laifa Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Microvascular Invasion ◽  
Solitary Hepatocellular Carcinoma ◽  
Preoperative Predictors

Prognostic Value and Prediction of Extratumoral Microvascular Invasion for Hepatocellular Carcinoma

2019 ◽  
Vol 26 (8) ◽  
pp. 2568-2576 ◽  
Author(s):  
Hidetoshi Nitta ◽  
Marc-Antoine Allard ◽  
Mylène Sebagh ◽  
Oriana Ciacio ◽  
Gabriella Pittau ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Microvascular Invasion

scholarly journals Prognostic value of a novel risk classification of microvascular invasion in patients with hepatocellular carcinoma after resection

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 5474-5486 ◽  
Author(s):  
Hui Zhao ◽  
Chuang Chen ◽  
Xu Fu ◽  
Xiaopeng Yan ◽  
Wenjun Jia ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Risk Classification ◽  
Microvascular Invasion

scholarly journals A predictive and prognostic model for hepatocellular carcinoma with microvascular invasion based TCGA database genomics

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jin Wang ◽  
Zhi-Wen Ding ◽  
Kuang Chen ◽  
Yan-Zhe Liu ◽  
Nan Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Survival Analysis ◽  
Prediction Model ◽  
Prognostic Value ◽  
Tissue Microarrays ◽  
Microvascular Invasion ◽  
Classification Model ◽  
Term Survival ◽  
Significant Difference ◽  
Key Genes

Abstract Background Microvascular invasion (MVI) adversely affects postoperative long-term survival outcomes in patients with hepatocellular carcinoma (HCC). There is no study addressing genetic changes in HCC patients with MVI. We first screened differentially expressed genes (DEGs) in patients with and without MVI based on TCGA data, established a prediction model and explored the prognostic value of DEGs for HCC patients with MVI. Methods In this paper, gene expression and clinical data of liver cancer patients were downloaded from the TCGA database. The DEG analysis was conducted using DESeq2. Using the least absolute shrinkage and selection operator, MVI-status-related genes were identified. A Kaplan-Meier survival analysis was performed using these genes. Finally, we validated two genes, HOXD9 and HOXD10, using two sets of HCC tissue microarrays from 260 patients. Results Twenty-three MVI-status-related key genes were identified. Based on the key genes, we built a classification model using random forest and time-dependent receiver operating characteristic (ROC), which reached 0.814. Then, we performed a survival analysis and found ten genes had a significant difference in survival time. Simultaneously, using two sets of 260 patients’ HCC tissue microarrays, we validated two key genes, HOXD9 and HOXD10. Our study indicated that HOXD9 and HOXD10 were overexpressed in HCC patients with MVI compared with patients without MVI, and patients with MVI with HOXD9 and 10 overexpression had a poorer prognosis than patients with MVI with low expression of HOXD9 and 10. Conclusion We established an accurate TCGA database-based genomics prediction model for preoperative MVI risk and studied the prognostic value of DEGs for HCC patients with MVI. These DEGs that are related to MVI warrant further study regarding the occurrence and development of MVI.

Preoperative predictors of microvascular invasion in multinodular hepatocellular carcinoma

2013 ◽  
Vol 39 (8) ◽  
pp. 858-864 ◽  
Author(s):  
W.-C. Zhao ◽  
L.-F. Fan ◽  
N. Yang ◽  
H.-B. Zhang ◽  
B.-D. Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion ◽  
Preoperative Predictors

Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma

2013 ◽  
Vol 44 (8) ◽  
pp. 846-853 ◽  
Author(s):  
Fumitoshi Hirokawa ◽  
Michihiro Hayashi ◽  
Yoshiharu Miyamoto ◽  
Mitsuhiro Asakuma ◽  
Tetsunosuke Shimizu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion ◽  
Solitary Hepatocellular Carcinoma

scholarly journals Prediction of microvascular invasion in solitary hepatocellular carcinoma ≤ 5 cm based on computed tomography radiomics

2021 ◽  
Vol 27 (17) ◽  
pp. 2015-2024
Author(s):  
Peng Liu ◽  
Xian-Zhen Tan ◽  
Ting Zhang ◽  
Qian-Biao Gu ◽  
Xian-Hai Mao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hepatocellular Carcinoma ◽  
Microvascular Invasion ◽  
Solitary Hepatocellular Carcinoma
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