Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

2018 ◽  
Vol 49 (3) ◽  
pp. 344-354 ◽  
Author(s):  
Han Wang ◽  
Meng‐Chao Wu ◽  
Wen‐Ming Cong
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Poor Prognosis ◽  
Microvascular Invasion ◽  
Propensity Score Matching Analysis ◽  
Solitary Hepatocellular Carcinoma

scholarly journals Poor Prognoses of Young Hepatocellular Carcinoma Patients with Microvascular Invasion: A Propensity Score Matching Cohort Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Lian Li ◽  
Liangliang Xu ◽  
Tianfu Wen ◽  
Hong Wu ◽  
Wentao Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Proportional Hazards ◽  
Age Groups ◽  
Disease Free Survival ◽  
Cox Proportional Hazards ◽  
Hazard Ratio ◽  
Microvascular Invasion ◽  
Propensity Score Matching Analysis

The relationship between age and the prognosis of patients with hepatocellular carcinoma (HCC) has been widely investigated. However, few studies have focused on the influence of patient age on the prognosis of HCC with microvascular invasion (MVI). Patients with histologically confirmed HCC with MVI who underwent hepatectomy between 2008 and 2016 were retrospectively enrolled in this study and allocated to younger (young group) and older age groups (old group) according to age< or ≥60 years. A propensity score matching analysis was performed, and prognostic factors evaluated by Kaplan–Meier curves and Cox proportional hazards regression. Intraoperative and postoperative characteristics were compared between the two groups. A total of 374 patients were enrolled in this study. There were 84 patients in each group after a 1 : 1 propensity score matching analysis. The rates of both disease-free survival (DFS) and overall survival (OS) differed significantly between the age groups. By univariate and multivariate analyses, age<60 years was significantly associated with DFS (hazard ratio, 1.590; 95% CI, 1.135–2.228) and OS (hazard ratio, 1.837; 95% CI, 1.259–2.680). There were no significant differences in intraoperative or postoperative characteristics between the two age groups. In patients with histologically confirmed HCC with MVI, the prognosis is poorer for those aged younger than 60 years than for those aged 60 years or older. Hepatectomy can be safely performed in selected older patients.

Sign in / Sign up

Export Citation Format

Share Document