scholarly journals HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation

Oncotarget ◽  
2014 ◽  
Vol 5 (4) ◽  
pp. 1091-1100 ◽  
Author(s):  
Charles Cobbs ◽  
Sabeena Khan ◽  
Lisa Matlaf ◽  
Sean McAllister ◽  
Alex Zider ◽  
...  
Keyword(s):  
Glycoprotein B ◽  
Pdgfr Alpha ◽  
Primary Glioblastomas

The Effect of Glycoprotein B DNA Immuniation on HSV-l Lethal Infection of BALB/c Mice

2010 ◽  
Vol 4 (3) ◽  
pp. 47-51
Author(s):  
T Bamdad ◽  
M Roostaee ◽  
M Sadeghizadeh ◽  
F Mahboudi ◽  
A Kazemnejad ◽  
...  
Keyword(s):  
Glycoprotein B ◽  
Lethal Infection

scholarly journals Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

2021 ◽  
Vol 7 (10) ◽  
pp. eabf3178
Author(s):  
Yuhang Liu ◽  
Kyle P. Heim ◽  
Ye Che ◽  
Xiaoyuan Chi ◽  
Xiayang Qiu ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Human Cytomegalovirus ◽  
Transmembrane Domain ◽  
Proximal Region ◽  
Viral Envelope ◽  
Vaccine Antigen ◽  
Glycoprotein B ◽  
Structural Basis ◽  
Fusion Inhibitor ◽  
Host Cell Membrane

Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity. HCMV glycoprotein B (gB) transitions irreversibly from a metastable prefusion to a stable postfusion conformation to fuse the viral envelope with a host cell membrane during entry. We stabilized prefusion gB on the virion with a fusion inhibitor and a chemical cross-linker, extracted and purified it, and then determined its structure to 3.6-Å resolution by electron cryomicroscopy. Our results revealed the structural rearrangements that mediate membrane fusion and details of the interactions among the fusion loops, the membrane-proximal region, transmembrane domain, and bound fusion inhibitor that stabilized gB in the prefusion state. The structure rationalizes known gB antigenic sites. By analogy to successful vaccine antigen engineering approaches for other viral pathogens, the high-resolution prefusion gB structure provides a basis to develop stabilized prefusion gB HCMV vaccine antigens.

scholarly journals TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas

2014 ◽  
Vol 17 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Matthias Simon ◽  
Ismail Hosen ◽  
Konstantinos Gousias ◽  
Sivaramakrishna Rachakonda ◽  
Barbara Heidenreich ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Independent Prognostic Factor ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations ◽  
Primary Glioblastomas

Neuronal pathways of viral invasion in mice after intranasal inoculation of pseudorabies virus PrV-9112C2 expressing bovine herpesvirus 1 glycoprotein B

2006 ◽  
Vol 12 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Nils Damann ◽  
Robert Klopfleisch ◽  
Markus Rothermel ◽  
Julia F Doerner ◽  
Thomas C Mettenleiter ◽  
...  
Keyword(s):  
Pseudorabies Virus ◽  
Bovine Herpesvirus ◽  
Glycoprotein B ◽  
Bovine Herpesvirus 1 ◽  
Intranasal Inoculation ◽  
Herpesvirus 1

scholarly journals Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Valentina Caldera ◽  
Marta Mellai ◽  
Laura Annovazzi ◽  
Angela Piazzi ◽  
Michele Lanotte ◽  
...  
Keyword(s):  
Stem Cells ◽  
Genetic Alterations ◽  
Tumor Stem Cells ◽  
Primary Tumors ◽  
Immunodeficient Mice ◽  
Brain Tumor Stem Cells ◽  
Tumor Phenotype ◽  
Fetal Bovine ◽  
Primary Glioblastomas

Formation of neurospheres (NS) in cultures of glioblastomas (GBMs), with self-renewal, clonogenic capacities, and tumorigenicity following transplantation into immunodeficient mice, may denounce the existence of brain tumor stem cells (BTSCs) in vivo. In sixteen cell lines from resected primary glioblastomas, NS showed the same genetic alterations as primary tumors and the expression of stemness antigens. Adherent cells (AC), after adding 10% of fetal bovine serum (FBS) to the culture, were genetically different from NS and prevailingly expressed differentiation antigens. NS developed from a highly malignant tumor phenotype with proliferation, circumscribed necrosis, and high vessel density. Beside originating from transformed neural stem cells (NSCs), BTSCs may be contained within or correspond to dedifferentiated cells after mutation accumulation, which reacquire the expression of stemness antigens.

scholarly journals Cytomegalovirus Glycoprotein B Groups in Human Immunodeficiency Virus–Infected Patients with Incident Retinitis

2002 ◽  
Vol 186 (1) ◽  
pp. 114-117 ◽  
Author(s):  
W. Lawrence Drew ◽  
Sunwen Chou ◽  
Richard C. Miner ◽  
Beth A. Mohr ◽  
Michael P. Busch ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Glycoprotein B ◽  
Immunodeficiency Virus

scholarly journals Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection

Virology ◽  
2016 ◽  
Vol 490 ◽  
pp. 1-5 ◽  
Author(s):  
Nora F. Mahmoud ◽  
Chyntia Jasirwan ◽  
Satoshi Kanemoto ◽  
Aika Wakata ◽  
Bochao Wang ◽  
...  
Keyword(s):  
Cytoplasmic Tail ◽  
Glycoprotein B ◽  
Tail Domain
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