scholarly journals Clinical significance of MSKCC nomogram on guiding the application of touch imprint cytology and frozen section in intraoperative assessment of breast sentinel lymph nodes

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78105-78112 ◽  
Author(s):  
Lisha Sun ◽  
Guanglei Chen ◽  
Yizhen Zhou ◽  
Lei Zhang ◽  
Zining Jin ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Clinical Significance ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Intraoperative Assessment ◽  
Touch Imprint Cytology ◽  
Mskcc Nomogram

GeneSearch™ BLN Assay could replace frozen section and touch imprint cytology for intra-operative assessment of breast sentinel lymph nodes

Breast Cancer ◽  
2013 ◽  
Vol 21 (5) ◽  
pp. 583-589 ◽  
Author(s):  
Yong-sheng Wang ◽  
Yan-hui Liu ◽  
Tao Ou-yang ◽  
Xin-hua Yang ◽  
Jiong Wu ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Touch Imprint Cytology ◽  
Operative Assessment

scholarly journals Intraoperative imprint cytology of sentinel lymph nodes in breast cancer patients: Comparation with frozen section

2020 ◽  
Vol 77 (2) ◽  
pp. 196-200
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Ferenc Vicko ◽  
Milana Panjkovic ◽  
Zoran Radovanovic ◽  
Tijana Vasiljevic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Breast Cancer Patients ◽  
Touch Imprint Cytology

Background/Aim. Sentinel lymph node (SLN) biopsy has been established as the standard of care for axillary staging in patients with invasive breast carcinoma and clinically negative lymph nodes. Intraoperative assessment of sentinel lymph nodes might be done by frozen section (FS), touch imprint cytology (TIC) and one step nucleic acid amplification. The aim of this study was to review our institution's results with SLN biopsy using TIC and FS technique as intraoperative diagnostic tool for breast cancer patients. Methods. SLNs from 101 patients were examined intraoperatively by frozen hematoxylin-eosin (H&E) stain and by touch imprint cytology. Results of TIC were compared with FS and permanent histology sections. Results. The total number of dissected SLNs was 163 with a mean of 1.6 (1?4) per patient. The permanent H&E identified 19 (19%) patients with a sentinel lymph node metastasis and 82 (81%) patients with tumor-free sentinel nodes. The sensitivity/ specificity rates were 73.7%/99.3%, respectively for TIC and 84.2%/100%, respectively for FS. Relevant positive/ negative predictive values were 93.3%/96.6%, respectively for TIC and 100%/97.9%, respectively for FS. Conclusion. Our experience with TIC and FS for the intraoperative evaluation of SLNs is similar to the findings from previously reported studies. We detected the high specificity for both methods, but TIC technique appeared to be less sensitive than FS in detecting SLN metastases in breast cancer patients. TIC could be recommended as reasonable alternative to frozen section due to its simplicity and low cost.

Prospective Comparison of Intraoperative Touch Imprint Cytology and Frozen Section Histology on Axillary Sentinel Lymph Nodes in Early Breast Cancer Patients

2020 ◽  
Vol 64 (5) ◽  
pp. 492-497
Author(s):  
Makoto Abe ◽  
Tetsuya Yamada ◽  
Akinobu Nakano
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Sentinel Nodes ◽  
Node Negative ◽  
Touch Imprint Cytology ◽  
Node Negative Breast Cancer ◽  
Node Metastases

Introduction: Since the late 1970s, sentinel lymph node biopsy (SLNB) has been used for several solid malignancies to identify lymph node metastases. This procedure is associated with less surgical morbidity than complete lymphadenectomy. Recent evidence suggests that axillary lymphadenectomy is not required for breast sentinel nodes with micrometastases (≤2 mm). Current clinical management of sentinel nodes indicates that only macrometastases (>2 mm) should be detected intraoperatively. In Japan, an intraoperative histopathological frozen section (FS) method is used to identify lymph node metastases, but this method takes more than 30 min and requires complex techniques and expensive equipment. Touch imprint cytology (TIC) is an easier, less expensive, and faster method, but its sensitivity has been shown to be low. Objective: The purpose of this study was to determine if TIC is more useful than FS in identifying macrometastases in sentinel lymph nodes in preoperative node-negative breast cancer operations. Methods: A prospective review of 49 consecutive patients with node-negative breast cancer treated with SLNB and intraoperative TIC and FS between November 2017 and June 2019 was performed. TIC samples were stained using Papanicolaou and Diff-Quick stains. Results were compared with routine postoperative paraffin sections. Results: With TIC, the Papanicolaou stain took a mean of 12 min, and the Diff-Quick stain took a mean of 10 min. Results of both TIC stain methods were the same. In contrast, the FS method took a mean of 80 min (including the transfer of specimens to a different hospital with the necessary equipment). TIC confirmed macrometastases in 5 cases. All macrometastases were diagnosed equally by the 2 techniques. Both the sensitivity and specificity of TIC were 100% for detection of macrometastases. Conclusion: TIC of SLNB for breast cancer is an easy and useful method for the detection of macrometastases of breast sentinel nodes.

Correlation between histological characteristics and intra-operative touch imprint cytology in axillary sentinel lymph nodes.

2012 ◽  
Vol 38 (5) ◽  
pp. 429
Author(s):  
David Thurtle ◽  
Gurdeep Mannu ◽  
Raman Vinayagam ◽  
Sally Owen ◽  
Simon Pilgrim ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Touch Imprint Cytology ◽  
Histological Characteristics
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