scholarly journals Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 48436-48452 ◽  
Author(s):  
Xiang Zheng ◽  
Kati Turkowski ◽  
Javier Mora ◽  
Bernhard Brüne ◽  
Werner Seeger ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Associated Macrophages ◽  
Novel Strategy

119 A novel strategy to inhibit Stat3 for human cancer therapy

2004 ◽  
Vol 2 (8) ◽  
pp. 38-39
Author(s):  
N. Jing ◽  
Y. Li ◽  
W. Sha ◽  
W. Xiong ◽  
D. Tweardy
Keyword(s):  
Cancer Therapy ◽  
Human Cancer ◽  
Novel Strategy

Hyaluronic acid nanoparticle-encapsulated microRNA-125b repolarizes tumor-associated macrophages in pancreatic cancer

Nanomedicine ◽  
2021 ◽  
Vol 16 (25) ◽  
pp. 2291-2303
Author(s):  
Neha N Parayath ◽  
Brian V Hong ◽  
Gerardo G Mackenzie ◽  
Mansoor M Amiji
Keyword(s):  
Intraperitoneal Administration ◽  
Genetically Engineered ◽  
Pancreatic Tumors ◽  
M2 Macrophage ◽  
Tumor Associated Macrophages ◽  
Fourfold Increase ◽  
Targeted Nanoparticles ◽  
Genetically Engineered Mice ◽  
Novel Strategy

Aim: To investigate a novel strategy to target tumor-associated macrophages and reprogram them to an antitumor phenotype in pancreatic adenocarcinoma (PDAC). Methods: M2 peptides were conjugated to HA-PEG/HA-PEI polymer to form self-assembled nanoparticles with miR-125b. The efficacy of HA-PEI/PEG-M2peptide nanoparticles in pancreatic tumors from LSL-KrasG12D/+, LSL-Trp53R172H/+, Pdx1-Cre genetically engineered mice was evaluated. Results: In vitro M2 macrophage-specific delivery of targeted nanoformulations was demonstrated. Intraperitoneal administration of M2-targeted nanoparticles showed preferential accumulation in the pancreas of KPC-PDAC mice and an above fourfold increase in the M1-to-M2 macrophage ratio compared with transfection with scrambled miR. Conclusion: M2-targeted HA-PEI/PEG nanoparticles with miR-125b can transfect tumor-associated macrophages in pancreatic tissues and may have implications for PDAC immunotherapy.

Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (22) ◽  
pp. 12126-12132
Author(s):  
Chenxing Fu ◽  
Jie Zhan ◽  
Junqi Huai ◽  
Shaodan Ma ◽  
Minghui Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Growth ◽  
Cancer Therapy ◽  
Endoplasmic Reticulum Stress ◽  
Self Assembly ◽  
Novel Strategy

We designed furin-instructed self-assembly to block the ER-to-Golgi traffic for inhibiting MDA-MB-468 cell growth. This disturbance of the cellular proteostasis through molecular self-assembly may provide a novel strategy for cancer therapy.

scholarly journals Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy (Review)

2017 ◽  
Author(s):  
Hani Choudhry ◽  
Mazin Zamzami ◽  
Ziad Omran ◽  
Wei Wu ◽  
Marc Mousli ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Novel Strategy

PROTACs: A novel strategy for cancer therapy

2020 ◽  
Vol 67 ◽  
pp. 171-179 ◽  
Author(s):  
Jing Liu ◽  
Jia Ma ◽  
Yi Liu ◽  
Jun Xia ◽  
Yuyun Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Novel Strategy
Sign in / Sign up

Export Citation Format

Share Document