scholarly journals Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease

Oncotarget ◽  
2017 ◽  
Vol 8 (23) ◽  
pp. 38008-38021 ◽  
Author(s):  
Fei Mao ◽  
Qiang Tu ◽  
Li Wang ◽  
Fuliang Chu ◽  
Xia Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bowel Disease ◽  
Therapeutic Applications ◽  
Inflammatory Bowel

scholarly journals Mechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Xing-hua Pan ◽  
Qing-qing Li ◽  
Xiang-qing Zhu ◽  
Zi-an Li ◽  
Xue-min Cai ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Normal Control ◽  
Bowel Disease ◽  
Therapeutic Effects ◽  
Colon Tissue ◽  
Junction Protein ◽  
Inflammatory Bowel

AbstractInflammatory bowel disease (IBD) is a persistent and chronic disease that is characterized by destructive gastrointestinal (GI) inflammation. Researchers are trying to identify and develop new and more effective treatments with no side effects. Acute and chronic mouse models of IBD were established using dextran sulfate sodium (DSS) solution. To evaluate the efficacy and mechanism, umbilical cord mesenchymal stem cells (UCMSCs) were obtained from Kunming (KM) mice and humans. In the chronic IBD study, the survival rates of the normal control, model, mouse UCMSC (mUCMSC) and human UCMSC (hUCMSC) groups were 100%, 40%, 86.7%, and 100%, respectively. The histopathological scores of the normal control, intraperitoneal injection, intravenous treatment, and model groups were 0.5 ± 0.30, 5.9 ± 1.10, 8.7 ± 1.39, and 8.8 ± 1.33 (p = 0.021). UCMSCs promoted the expression of the intestinal tight junction protein occludin, downregulated the protein expression of the autophagy marker LC3A/B in colon tissue, and upregulated the expression of VEGF-A and VEGFR-1 at the injured site. This study provides an experimental model for elucidating the therapeutic effects of UCMSCs in IBD. We provide a theoretical basis and method for the clinical treatment of IBD using UCMSCs.

scholarly journals Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Fei Mao ◽  
Yunbing Wu ◽  
Xudong Tang ◽  
Jingjing Kang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Bowel Disease ◽  
Tissue Injury ◽  
Underlying Mechanism ◽  
Human Umbilical Cord ◽  
Inflammatory Bowel

Exosomes secreted by mesenchymal stem cells (MSCs) have shown repairing effects on several tissue injury diseases. In this study, we aimed to investigate the effects of exosomes released from human umbilical cord mesenchymal stem cells (hucMSCs) on the treatment of dextran sulfate sodium- (DSS-) induced inflammatory bowel disease (IBD) and to explore the underlying mechanism. We found that indocyanine green (ICG) labeled exosomes homed to colon tissues of IBD mice at 12 hours after injection. Exosomes significantly relieved the severity of IBD in mice as hucMSCs. The expression of IL-10 gene was increased while that of TNF-α, IL-1β, IL-6, iNOS, and IL-7 genes was decreased in the colon tissues and spleens of exosomes-treated mice. Furthermore, the infiltration of macrophages into the colon tissues was decreased by exosome treatment in IBD mice. In addition, we provided evidence that in vitro coculture with exosomes inhibited the expression of iNOS and IL-7 in mouse enterocoelia macrophages. Moreover, we found that the expression of IL-7 was higher in the colon tissues of colitis patients than that of healthy controls. Our findings suggest that exosomes from hucMSCs have profound effects on alleviating DSS-induced IBD and may exert their impact through the modulation of IL-7 expression in macrophages.

Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease

2019 ◽  
pp. 125-138
Author(s):  
Vladislav Volarevic ◽  
Bojana Simovic Markovic ◽  
C. Randall Harrell ◽  
Crissy Fellabaum ◽  
Nemanja Jovicic ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bowel Disease ◽  
Inflammatory Bowel
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