scholarly journals Enrichment of Human ESC-Derived Multipotent Mesenchymal Stem Cells with Immunosuppressive and Anti-Inflammatory Properties Capable to Protect Against Experimental Inflammatory Bowel Disease

Stem Cells ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. 251-262 ◽  
Author(s):  
Laura Sánchez ◽  
Iván Gutierrez-Aranda ◽  
Gertrudis Ligero ◽  
Ruth Rubio ◽  
Martín Muñoz-López ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bowel Disease ◽  
Experimental Inflammatory Bowel Disease ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Multipotent Mesenchymal Stem Cells

scholarly journals Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease

Oncotarget ◽  
2017 ◽  
Vol 8 (23) ◽  
pp. 38008-38021 ◽  
Author(s):  
Fei Mao ◽  
Qiang Tu ◽  
Li Wang ◽  
Fuliang Chu ◽  
Xia Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bowel Disease ◽  
Therapeutic Applications ◽  
Inflammatory Bowel

scholarly journals Mechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Xing-hua Pan ◽  
Qing-qing Li ◽  
Xiang-qing Zhu ◽  
Zi-an Li ◽  
Xue-min Cai ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Normal Control ◽  
Bowel Disease ◽  
Therapeutic Effects ◽  
Colon Tissue ◽  
Junction Protein ◽  
Inflammatory Bowel

AbstractInflammatory bowel disease (IBD) is a persistent and chronic disease that is characterized by destructive gastrointestinal (GI) inflammation. Researchers are trying to identify and develop new and more effective treatments with no side effects. Acute and chronic mouse models of IBD were established using dextran sulfate sodium (DSS) solution. To evaluate the efficacy and mechanism, umbilical cord mesenchymal stem cells (UCMSCs) were obtained from Kunming (KM) mice and humans. In the chronic IBD study, the survival rates of the normal control, model, mouse UCMSC (mUCMSC) and human UCMSC (hUCMSC) groups were 100%, 40%, 86.7%, and 100%, respectively. The histopathological scores of the normal control, intraperitoneal injection, intravenous treatment, and model groups were 0.5 ± 0.30, 5.9 ± 1.10, 8.7 ± 1.39, and 8.8 ± 1.33 (p = 0.021). UCMSCs promoted the expression of the intestinal tight junction protein occludin, downregulated the protein expression of the autophagy marker LC3A/B in colon tissue, and upregulated the expression of VEGF-A and VEGFR-1 at the injured site. This study provides an experimental model for elucidating the therapeutic effects of UCMSCs in IBD. We provide a theoretical basis and method for the clinical treatment of IBD using UCMSCs.

Sign in / Sign up

Export Citation Format

Share Document