scholarly journals Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 31915-31922 ◽  
Author(s):  
Xia Chen ◽  
Rui Wu ◽  
Yiwei Kong ◽  
Yuting Yang ◽  
Yu Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats

Hyptis verticillata attenuates dyslipidaemia, oxidative stress and hepato-renal damage in streptozotocin-induced diabetic rats

Life Sciences ◽  
2019 ◽  
Vol 219 ◽  
pp. 283-293 ◽  
Author(s):  
Ironya Ogar ◽  
Godwin Eneji Egbung ◽  
Victor Udo Nna ◽  
Item Justin Atangwho ◽  
Edisua Hogan Itam
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats

scholarly journals Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2812 ◽  
Author(s):  
Adriana Rodríguez-Méndez ◽  
Wendy Carmen-Sandoval ◽  
Consuelo Lomas-Soria ◽  
Ramón Guevara-González ◽  
Rosalía Reynoso-Camacho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Methanol Extract ◽  
Serum Insulin ◽  
Diabetic Rats ◽  
Physiological Parameters ◽  
Hypolipidemic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Uptake Activity

In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.

Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway

2014 ◽  
Vol 5 (5) ◽  
pp. 944-950 ◽  
Author(s):  
ShaoYi She ◽  
WeiJuan Liu ◽  
Tong Li ◽  
YingKai Hong
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats ◽  
Tgf Β1

The present study aimed to investigate the effects of pueraria on streptozotocine (STZ)-induced renal damage and its possible mechanisms.

Comparison of the Effects of Korean Ginseng and Heat-Processed Korean Ginseng on Diabetic Oxidative Stress

2008 ◽  
Vol 36 (05) ◽  
pp. 989-1004 ◽  
Author(s):  
Hyun Young Kim ◽  
Ki Sung Kang ◽  
Noriko Yamabe ◽  
Takako Yokozawa
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Renal Damage ◽  
Advanced Glycation Endproducts ◽  
Diabetic Rats ◽  
Heat Processing ◽  
Diabetic Rat ◽  
Thiobarbituric Acid Reactive Substance ◽  
Pathological Conditions ◽  
Korean Ginseng

To investigate the effects of Korean ginseng (KG, Panax ginseng C.A. Meyer) and heat-processed Korean ginseng (H-KG) on diabetic renal damage, we used the streptozotocin-induced diabetic rat model in this study. The diabetes-induced physiological abnormalities at early-stage were attenuated by KG or H-KG administration through reducing the blood glucose level and improving renal function. The oxidative stress-induced increases in serum and renal thiobarbituric acid-reactive substance levels were significantly reduced by KG and H-KG administrations. Moreover, the protein expressions related to oxidative stress and advanced glycation endproducts were significantly reduced in diabetic rats and/or not significantly increased compared to normal rats by KG or H-KG administration. All of these beneficial effects of H-KG in diabetic rats were stronger than those of KG. Therefore, KG and H-KG may improve diabetic pathological conditions and prevent renal damage associated with diabetic nephropathy, and these protective effects of KG can be improved by heat-processing. This study provides scientific evidence that H-KG may be a potential therapeutic agent for pathological conditions associated with diabetic complications including diabetic nephropathy.

Syzygium aromaticum Reduces Diabetes-induced Glucotoxicity via the NRF2/Glo1 Pathway

Planta Medica ◽  
2020 ◽  
Vol 86 (12) ◽  
pp. 876-883
Author(s):  
Moon Ho Do ◽  
Jiwon Choi ◽  
Yoonsook Kim ◽  
Sang Keun Ha ◽  
Guijae Yoo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Treated Group ◽  
Diabetic Rats ◽  
Related Factor ◽  
Syzygium Aromaticum ◽  
Inhibitory Effects ◽  
Collagen Crosslinks ◽  
Glycation End Products ◽  
And Oxidative Stress

AbstractAdvanced glycation end products and methylglyoxal are known to show increased levels in diabetic conditions and induce diverse metabolic disorders. However, the antiglycation ability of the bark of Syzygium aromaticum is not yet studied. In this study, we determined the inhibitory effects of S. aromaticum on AGE formation. Moreover, S. aromaticum showed breakage and inhibitory ability against the formation of AGE-collagen crosslinks. In SV40 MES13 cells, treatment with the S. aromaticum extract significantly ameliorated MG-induced oxidative stress as well as cytotoxicity. Furthermore, in the S. aromaticum extract-treated group, there was a reduction in levels of several diabetic markers, such as blood glucose, kidney weight, and urinary albumin to creatinine ratio in streptozotocin-induced diabetic rats. Treatment with the S. aromaticum extract significantly increased the expression of nuclear factor erythroid 2-related factor 2, a transcription factor involved in the expression of antioxidant enzymes. Moreover, the treatment significantly upregulated the expression of glyoxalase 1 and downregulated the expression of receptor for AGEs. These results suggest that the S. aromaticum extract might ameliorate diabetes-induced renal damage by inhibiting the AGE-induced glucotoxicity and oxidative stress through the Nrf2/Glo1 pathway.

Combination of Naringenin and Lisinopril Ameliorates Nephropathy in Type-1 Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Yogesh A. Kulkarni ◽  
Sachin V. Suryavanshi
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Renal Damage ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Glycation End Products ◽  
Histopathological Studies ◽  
Diabetes Induction

Background: Diabetes is a metabolic disorder affecting large percentage of population worldwide. Chronic hyperglycemic condition leads to generation of advanced glycation end products, reactive oxygen species and inflammatory cytokines, which worsen functioning of kidney. Clinical management of diabetic nephropathy is difficult as it requires multifocused approach. Hence, Combination of lisinopril a drug used in clinical practice for nephropathy and naringenin, a flavonoid reported to have significant effect in nephropathy may show additive of synergistic effect with less side effects. Objective: The objective of present study was to evaluate the effect of combination of lisinopril with naringenin in diabetic nephropathy. Methods: Diabetes was induced in male Sprague Dawley rats by streptozotocin (55 mg/kg, i.p.). After four weeks of diabetes induction animals were treated with naringenin alone and combination of Lisinopril and naringenin for next four weeks. At the end of study, various urine and biochemical parameters were evaluated. Oxidative stress parameters like malondialdehyde, reduced glutathione; catalase and superoxide dismutase for kidney tissues were estimated and histopathology studies of kidney were carried out. Results: Combination of lisinopril (10 mg/kg) and naringenin (25 and 50 mg/kg) treatment showed significant improvement in the biochemical and urine parameters. Combination treatment also attenuated renal oxidative stress and renal damage as observed in histopathological studies. Conclusion: Treatment with combination of lisinopril and naringenin showed promising effect in diabetic nephropathy in rats.

scholarly journals 6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 317
Author(s):  
Saleh A. Almatroodi ◽  
Abdullah M. Alnuqaydan ◽  
Ali Yousif Babiker ◽  
Mashael Abdullah Almogbel ◽  
Amjad Ali Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Blood Glucose ◽  
Protein Expression ◽  
Antioxidant Enzyme ◽  
Renal Damage ◽  
Inflammatory Marker ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Kidney Damage

The aim of present study is to investigate the role of 6-gingerol in ameliorating the renal injury in streptozotocin (STZ)-induced diabetic rats. The diabetes was induced by using a single dose of freshly prepared STZ (55 mg/kg body weight) intraperitoneally which causes the degeneration of pancreatic Langerhans islet β-cells. The diabetic rats were treated with oral gavage of 6-gingerol (10 mg/kg b.w.). The treatment plan was continued for 8 weeks successively and the body weight and fasting blood glucose levels were weekly checked. The biochemical parameters like lipid profile, kidney profile, antioxidant enzyme levels, lipid peroxidation and anti-inflammatory marker levels were investigated after the treatment plant. The pathological condition of kidneys was examined by haematoxylin-eosin (H&E) staining besides this analysis of NF-κB protein expression by immuno-histochemistry was performed. Some of the major parameters in diabetes control vs. normal control were reported as fasting blood glucose (234 ± 10 vs. 102 ± 8 mg/dL), serum creatinine (109.7 ± 7.2 vs. 78.9 ± 4.5 μmol/L) and urea (39.9 ± 1.8 vs. 18.6 mg/dL), lipid profile levels were significantly enhanced in diabetic rats. Moreover, diabetic rats were marked with decreased antioxidant enzyme levels and increased inflammatory markers. Treatment with 6-gingerol significantly restored the fasting blood glucose level, hyperlipidaemia, Malondialdehyde (MDA) and inflammatory marker levels, NF-κB protein expression and augmented the antioxidant enzyme levels in the kidneys of diabetic rats. The kidney damage was significantly normalized by the treatment of 6-gingerol and it provides an evidence that this novel compound plays a significant role in the protection of kidney damage. These findings demonstrate that 6-gingerol reduces lipid parameters, inflammation and oxidative stress in diabetic rats, thereby inhibiting the renal damage. Our results demonstrate that use of 6-gingerol could be a novel therapeutic approach to prevent the kidney damage associated with the diabetes mellitus.

Attenuation of oxidative stress in hepatic and pancreatic tissues of STZ-induced diabetic rats treated with aqueous extract of Vochysia rufa

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
NM De Gouveia ◽  
IB Moraes ◽  
RMF Sousa ◽  
MB Neto ◽  
AV Mundim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Diabetic Rats
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