Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway

2014 ◽  
Vol 5 (5) ◽  
pp. 944-950 ◽  
Author(s):  
ShaoYi She ◽  
WeiJuan Liu ◽  
Tong Li ◽  
YingKai Hong
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats ◽  
Tgf Β1

The present study aimed to investigate the effects of pueraria on streptozotocine (STZ)-induced renal damage and its possible mechanisms.

Hyptis verticillata attenuates dyslipidaemia, oxidative stress and hepato-renal damage in streptozotocin-induced diabetic rats

Life Sciences ◽  
2019 ◽  
Vol 219 ◽  
pp. 283-293 ◽  
Author(s):  
Ironya Ogar ◽  
Godwin Eneji Egbung ◽  
Victor Udo Nna ◽  
Item Justin Atangwho ◽  
Edisua Hogan Itam
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats

scholarly journals Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 31915-31922 ◽  
Author(s):  
Xia Chen ◽  
Rui Wu ◽  
Yiwei Kong ◽  
Yuting Yang ◽  
Yu Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Diabetic Rats

scholarly journals Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2812 ◽  
Author(s):  
Adriana Rodríguez-Méndez ◽  
Wendy Carmen-Sandoval ◽  
Consuelo Lomas-Soria ◽  
Ramón Guevara-González ◽  
Rosalía Reynoso-Camacho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Methanol Extract ◽  
Serum Insulin ◽  
Diabetic Rats ◽  
Physiological Parameters ◽  
Hypolipidemic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Uptake Activity

In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.

Comparison of the Effects of Korean Ginseng and Heat-Processed Korean Ginseng on Diabetic Oxidative Stress

2008 ◽  
Vol 36 (05) ◽  
pp. 989-1004 ◽  
Author(s):  
Hyun Young Kim ◽  
Ki Sung Kang ◽  
Noriko Yamabe ◽  
Takako Yokozawa
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Renal Damage ◽  
Advanced Glycation Endproducts ◽  
Diabetic Rats ◽  
Heat Processing ◽  
Diabetic Rat ◽  
Thiobarbituric Acid Reactive Substance ◽  
Pathological Conditions ◽  
Korean Ginseng

To investigate the effects of Korean ginseng (KG, Panax ginseng C.A. Meyer) and heat-processed Korean ginseng (H-KG) on diabetic renal damage, we used the streptozotocin-induced diabetic rat model in this study. The diabetes-induced physiological abnormalities at early-stage were attenuated by KG or H-KG administration through reducing the blood glucose level and improving renal function. The oxidative stress-induced increases in serum and renal thiobarbituric acid-reactive substance levels were significantly reduced by KG and H-KG administrations. Moreover, the protein expressions related to oxidative stress and advanced glycation endproducts were significantly reduced in diabetic rats and/or not significantly increased compared to normal rats by KG or H-KG administration. All of these beneficial effects of H-KG in diabetic rats were stronger than those of KG. Therefore, KG and H-KG may improve diabetic pathological conditions and prevent renal damage associated with diabetic nephropathy, and these protective effects of KG can be improved by heat-processing. This study provides scientific evidence that H-KG may be a potential therapeutic agent for pathological conditions associated with diabetic complications including diabetic nephropathy.

Syzygium aromaticum Reduces Diabetes-induced Glucotoxicity via the NRF2/Glo1 Pathway

Planta Medica ◽  
2020 ◽  
Vol 86 (12) ◽  
pp. 876-883
Author(s):  
Moon Ho Do ◽  
Jiwon Choi ◽  
Yoonsook Kim ◽  
Sang Keun Ha ◽  
Guijae Yoo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Treated Group ◽  
Diabetic Rats ◽  
Related Factor ◽  
Syzygium Aromaticum ◽  
Inhibitory Effects ◽  
Collagen Crosslinks ◽  
Glycation End Products ◽  
And Oxidative Stress

AbstractAdvanced glycation end products and methylglyoxal are known to show increased levels in diabetic conditions and induce diverse metabolic disorders. However, the antiglycation ability of the bark of Syzygium aromaticum is not yet studied. In this study, we determined the inhibitory effects of S. aromaticum on AGE formation. Moreover, S. aromaticum showed breakage and inhibitory ability against the formation of AGE-collagen crosslinks. In SV40 MES13 cells, treatment with the S. aromaticum extract significantly ameliorated MG-induced oxidative stress as well as cytotoxicity. Furthermore, in the S. aromaticum extract-treated group, there was a reduction in levels of several diabetic markers, such as blood glucose, kidney weight, and urinary albumin to creatinine ratio in streptozotocin-induced diabetic rats. Treatment with the S. aromaticum extract significantly increased the expression of nuclear factor erythroid 2-related factor 2, a transcription factor involved in the expression of antioxidant enzymes. Moreover, the treatment significantly upregulated the expression of glyoxalase 1 and downregulated the expression of receptor for AGEs. These results suggest that the S. aromaticum extract might ameliorate diabetes-induced renal damage by inhibiting the AGE-induced glucotoxicity and oxidative stress through the Nrf2/Glo1 pathway.

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