scholarly journals Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 38351-38366 ◽  
Author(s):  
Benoît Romain ◽  
Radhia Benbrika-Nehmar ◽  
Laetitia Marisa ◽  
Michèle Legrain ◽  
Viviane Lobstein ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Tumor Growth ◽  
Histone Hypoacetylation

scholarly journals Resveratrol Enhances Inhibition Effects of Cisplatin on Cell Migration and Invasion and Tumor Growth in Breast Cancer MDA-MB-231 Cell Models In Vivo and In Vitro

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2204
Author(s):  
Meng-Die Yang ◽  
Yang Sun ◽  
Wen-Jun Zhou ◽  
Xiao-Zheng Xie ◽  
Qian-Mei Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Growth ◽  
Cell Viability ◽  
Synergistic Effects ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tgf Β1

Triple-negative breast cancer (TNBC) is a refractory type of breast cancer that does not yet have clinically effective drugs. The aim of this study is to investigate the synergistic effects and mechanisms of resveratrol combined with cisplatin on human breast cancer MDA-MB-231 (MDA231) cell viability, migration, and invasion in vivo and in vitro. In vitro, MTS assays showed that resveratrol combined with cisplatin inhibits cell viability as a concentration-dependent manner, and produced synergistic effects (CI < 1). Transwell assay showed that the combined treatment inhibits TGF-β1-induced cell migration and invasion. Immunofluorescence assays confirmed that resveratrol upregulated E-cadherin expression and downregulated vimentin expression. Western blot assay demonstrated that resveratrol combined with cisplatin significantly reduced the expression of fibronectin, vimentin, P-AKT, P-PI3K, P-JNK, P-ERK, Sma2, and Smad3 induced by TGF-β1 (p < 0.05), and increased the expression of E-cadherin (p < 0.05), respectively. In vivo, resveratrol enhanced tumor growth inhibition and reduced body weight loss and kidney function impairment by cisplatin in MDA231 xenografts, and significantly reduced the expressions of P-AKT, P-PI3K, Smad2, Smad3, P-JNK, P-ERK, and NF-κB in tumor tissues (p < 0.05). These results indicated that resveratrol combined with cisplatin inhibits the viability of breast cancer MDA231 cells synergistically, and inhibits MDA231 cells invasion and migration through Epithelial-mesenchymal transition (EMT) approach, and resveratrol enhanced anti-tumor effect and reduced side of cisplatin in MDA231 xenografts. The mechanism may be involved in the regulations of PI3K/AKT, JNK, ERK and NF-κB expressions.

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

2015 ◽  
Vol 459 (2) ◽  
pp. 327-332 ◽  
Author(s):  
Peng Yang ◽  
Zongwei Li ◽  
Yingying Wang ◽  
Lichao Zhang ◽  
Haili Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Colon Cancer Cells ◽  
Pyruvate Kinase M2

scholarly journals Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

Oncogene ◽  
2018 ◽  
Vol 38 (10) ◽  
pp. 1734-1750 ◽  
Author(s):  
J. P. Zepecki ◽  
K. M. Snyder ◽  
M. M. Moreno ◽  
E. Fajardo ◽  
A. Fiser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Migration ◽  
Tumor Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Migration

TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis

2005 ◽  
Author(s):  
Kyoko Yorozuya ◽  
Tetsuro Kubota ◽  
Masahiko Watanabe ◽  
Hirotoshi Hasegawa ◽  
Soji Ozawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Tumor Growth ◽  
Human Colon ◽  
Local Tumor ◽  
Human Colon Cancer ◽  
Local Tumor Growth

scholarly journals Silencing long non‑coding RNA, differentiation antagonizing non‑protein coding RNA promotes apoptosis and inhibits tumor growth in colon cancer

2018 ◽  
Author(s):  
Xiao‑Jin Yang ◽  
Jing‑Jing Zhao ◽  
Wei‑Jun Chen ◽  
Gen‑Gen Zhang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Growth ◽  
Protein Coding ◽  
Non Coding Rna ◽  
Long Non Coding Rna
Sign in / Sign up

Export Citation Format

Share Document