scholarly journals Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 38326-38336 ◽  
Author(s):  
Lars F. Petersen ◽  
Alexander C. Klimowicz ◽  
Shannon Otsuka ◽  
Anifat A. Elegbede ◽  
Stephanie K. Petrillo ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Resected Nsclc ◽  
Atm Protein

scholarly journals Positive tumour CD47 expression is an independent prognostic factor for recurrence in resected non-small cell lung cancer

ESMO Open ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. e000823
Author(s):  
Yan Xu ◽  
Ji Li ◽  
Bing Tong ◽  
Minjiang Chen ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Prognostic Factor ◽  
Infectious Diseases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Independent Prognostic Factor ◽  
Small Cell Lung ◽  
Cox Regression Analysis ◽  
Resected Nsclc

BackgroundImmunotherapy is a promising advance in oncology. Limited information exists regarding the interrelationship between CD47 expression and tumour-associated macrophage-related immuno-microenvironment in patients with non-small cell lung cancer (NSCLC). These factors may predict novel immunotherapy efficacy.Patients and methodsCD47 and PD-L1 expression was retrospectively assessed in 191 resected NSCLC specimens via immunohistochemistry. Forty-six patients with pulmonary infectious diseases were enrolled as the control group. The infiltration of macrophages (M2 and M1) and CD8+ T-lymphocytes was evaluated via dual-immunofluorescence staining. Targeted DNA sequencing was performed on NSCLC specimens. Survival analysis was performed using the Cox model.ResultsUsing 2+/3+ as a CD47 positive (CD47pos) expression cut-off, the prevalence of CD47pos expression in NSCLC was 33.0% (63/191), significantly higher than in pulmonary infectious diseases. CD47pos expression was significantly higher in female, non-smoking and adenocarcinoma patients (p=0.020, p<0.001 and p<0.001, respectively). Furthermore, CD47pos expression was significantly correlated with epidermal growth factor receptor mutation (p<0.001). The expression of CD47 (H-score) in NSCLC was negatively correlated with tumour PD-L1 expression (p=0.0346) and tumour mutation burden (p=0.0107). CD47pos expression was independently correlated with poor disease-free survival in patients with resected NSCLC in multivariate Cox regression analysis (p=0.035).ConclusionThis study revealed the demographic, molecular and immuno-microenvironment characteristics of CD47 expression in NSCLC. We identified tumour CD47pos expression as an independent prognostic factor for recurrence in resected NSCLC. Our findings illustrate the potential of anti-CD47 treatment in NSCLC.

DCC and TS protein expression in resected gastric cancer: A Hellenic Cooperative Oncology Group Study

Open Medicine ◽  
2008 ◽  
Vol 3 (1) ◽  
pp. 29-39
Author(s):  
Aristotle Bamias ◽  
George Fountzilas ◽  
Michael Michael ◽  
Christos Konstantaras ◽  
Eleftheria Vrettou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Prognostic Significance ◽  
Staining Intensity ◽  
Lymph Node Involvement ◽  
Independent Prognostic Factor ◽  
Node Involvement ◽  
Dcc Gene ◽  
Cause Specific Survival

AbstractThere is a high risk of relapse after resection of gastric cancer. We studied the prognostic significance of the deleted colorectal cancer (DCC) gene and thymidylate synthase (TS) protein expression after resection of gastric cancer. Protein expression in the primary tumor of 146 patients with serosal and/or lymph node involvement was studied immunohistochemically by using anti-DCC and anti-TS monoclonal antibodies. DCC expression was found in 69.9%, while low TS staining intensity (0+,1+) and focal staining (<25% of tumor cells stained) were found in 44.6% and 33.8%, respectively. Overall survival (OS) was significantly longer in patients with DCC (p=0.014) negative tumors. TS expression was not an independent prognostic factor. Lack of DCC expression was associated with significantly longer cause-specific survival (CSS) (p=0.040) after curative resection. In conclusion, DCC expression is an independent prognostic factor in patients undergoing resection of gastric cancer while TS expression was not associated with the prognosis in our study.

scholarly journals BMI-1 protein expression as a negative independent prognostic factor in DLBCL

2017 ◽  
Vol 35 ◽  
pp. 293-294
Author(s):  
M.Ø. Pedersen ◽  
M.L. Espersen ◽  
A.O. Gang ◽  
M.F. Breinholt ◽  
H. Knudsen ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor

scholarly journals Tumor Suppressor Effect of RBMS3 in Breast Cancer

2021 ◽  
Vol 20 ◽  
pp. 153303382110049
Author(s):  
Chunyang Wang ◽  
Yidan Wu ◽  
Yunqi Liu ◽  
Fushun Pan ◽  
Huijuan Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Poor Prognosis ◽  
Rna Binding ◽  
Independent Prognostic Factor ◽  
Cancer Tissue ◽  
Nuclear Staining ◽  
Cancer Tissues ◽  
Er Status

Background: RBMS3 (RNA-binding motif, single-stranded-intervacting protein 3) acts as a tumor-suppressive gene in a number of human cancers, however, its role in breast cancer is not fully understood. This study aimed to investigate the expression and clinicopathological significance of RBMS3 in breast cancer. Methods: A total of 998 breast cancer tissue samples in The Cancer Genome Atlas (TCGA) database with survival outcomes were divided into high RBMS3 expression and low expression groups using the median as the cutoff. Clinicopathological characteristics and prognosis were compared between the 2 groups. Results: TCGA showed that RBMS3 mRNA was downregulated in breast cancer tissues, and RBMS3 downregulation was correlated with poor prognosis. Immunohistochemistry staining of 127 paraffin-embedded breast cancer tissues showed that RBMS3 protein was localized in the cytoplasm and nucleus; however, nuclear staining was present in 90.0% of normal breast tissues but only 28.3% of breast cancer tissues. Decreased RBMS3 protein expression was significantly correlated with estrogen receptor (ER)-negative status and death at final follow-up. Patients with lower RBMS3 protein expression had substantially shorter survival than those with higher RBMS3 expression. Univariate and multivariate analysis indicated that the combination of RBMS3 expression and ER status (a variable designated as “cofactor”) was an independent prognostic factor in patients with breast cancer (hazard ratio [HR] = 0.420, 95% confidence interval [CI]: 0.223-0.791, P = 0.007). Conclusion: RBMS3 downregulation was correlated with poor prognosis in breast cancer patients, and the combination of RBMS3 expression and ER status was an independent prognostic factor.

scholarly journals ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor

2018 ◽  
Vol 50 (2) ◽  
pp. 495-505 ◽  
Author(s):  
Ji Won Lee ◽  
Sung Hye Park ◽  
Hyoung Jin Kang ◽  
Kyung Duk Park ◽  
Hee Young Shin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Alk Protein

scholarly journals Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2029
Author(s):  
Amer Abdulrahman ◽  
Markus Eckstein ◽  
Rudolf Jung ◽  
Juan Guzman ◽  
Katrin Weigelt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Cytokeratin 20 ◽  
Kaplan Meier ◽  
Increased Risk ◽  
Cox's Regression ◽  
Disease Specific

Prostate cancer, the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 protein expression in PCa by immunohistochemistry and to correlate the findings to the clinico-pathological data and prognosis. Immunohistochemical staining for GP88 was performed by TMA with samples from 442 PCa patients using an immunoreactive score (IRS). Altogether, 233 cases (52.7%) with negative GP88 staining (IRS < 2) and 209 cases (47.3%) with positive GP88 staining (IRS ≥ 2) were analyzed. A significant positive correlation was found for the GP88 IRS with the PSA value at prostatectomy and the cytoplasmic cytokeratin 20 IRS, whereas it was negatively associated with follow-up times. The association of GP88 staining with prognosis was further studied by survival analyses (Kaplan–Meier, univariate and multivariate Cox’s regression analysis). Increased GP88 protein expression appeared as an independent prognostic factor for overall, disease-specific and relapse-free survival in all PCa patients. Interestingly, in the subgroup of younger PCa patients (≤65 years), GP88 positivity was associated with a 3.8-fold (p = 0.004), a 6.0-fold (p = 0.008) and a 3.7-fold (p = 0.003) increased risk for death, disease-specific death and occurrence of a relapse, respectively. In the PCa subgroup with negative CK20 staining, GP88 positivity was associated with a 1.8-fold (p = 0.018) and a 2.8-fold increased risk for death and disease-specific death (p = 0.028). Altogether, GP88 protein positivity appears to be an independent prognostic factor for PCa patients.

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