scholarly journals BMI-1 protein expression as a negative independent prognostic factor in DLBCL

2017 ◽  
Vol 35 ◽  
pp. 293-294
Author(s):  
M.Ø. Pedersen ◽  
M.L. Espersen ◽  
A.O. Gang ◽  
M.F. Breinholt ◽  
H. Knudsen ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor

DCC and TS protein expression in resected gastric cancer: A Hellenic Cooperative Oncology Group Study

Open Medicine ◽  
2008 ◽  
Vol 3 (1) ◽  
pp. 29-39
Author(s):  
Aristotle Bamias ◽  
George Fountzilas ◽  
Michael Michael ◽  
Christos Konstantaras ◽  
Eleftheria Vrettou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Prognostic Significance ◽  
Staining Intensity ◽  
Lymph Node Involvement ◽  
Independent Prognostic Factor ◽  
Node Involvement ◽  
Dcc Gene ◽  
Cause Specific Survival

AbstractThere is a high risk of relapse after resection of gastric cancer. We studied the prognostic significance of the deleted colorectal cancer (DCC) gene and thymidylate synthase (TS) protein expression after resection of gastric cancer. Protein expression in the primary tumor of 146 patients with serosal and/or lymph node involvement was studied immunohistochemically by using anti-DCC and anti-TS monoclonal antibodies. DCC expression was found in 69.9%, while low TS staining intensity (0+,1+) and focal staining (<25% of tumor cells stained) were found in 44.6% and 33.8%, respectively. Overall survival (OS) was significantly longer in patients with DCC (p=0.014) negative tumors. TS expression was not an independent prognostic factor. Lack of DCC expression was associated with significantly longer cause-specific survival (CSS) (p=0.040) after curative resection. In conclusion, DCC expression is an independent prognostic factor in patients undergoing resection of gastric cancer while TS expression was not associated with the prognosis in our study.

scholarly journals Tumor Suppressor Effect of RBMS3 in Breast Cancer

2021 ◽  
Vol 20 ◽  
pp. 153303382110049
Author(s):  
Chunyang Wang ◽  
Yidan Wu ◽  
Yunqi Liu ◽  
Fushun Pan ◽  
Huijuan Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Poor Prognosis ◽  
Rna Binding ◽  
Independent Prognostic Factor ◽  
Cancer Tissue ◽  
Nuclear Staining ◽  
Cancer Tissues ◽  
Er Status

Background: RBMS3 (RNA-binding motif, single-stranded-intervacting protein 3) acts as a tumor-suppressive gene in a number of human cancers, however, its role in breast cancer is not fully understood. This study aimed to investigate the expression and clinicopathological significance of RBMS3 in breast cancer. Methods: A total of 998 breast cancer tissue samples in The Cancer Genome Atlas (TCGA) database with survival outcomes were divided into high RBMS3 expression and low expression groups using the median as the cutoff. Clinicopathological characteristics and prognosis were compared between the 2 groups. Results: TCGA showed that RBMS3 mRNA was downregulated in breast cancer tissues, and RBMS3 downregulation was correlated with poor prognosis. Immunohistochemistry staining of 127 paraffin-embedded breast cancer tissues showed that RBMS3 protein was localized in the cytoplasm and nucleus; however, nuclear staining was present in 90.0% of normal breast tissues but only 28.3% of breast cancer tissues. Decreased RBMS3 protein expression was significantly correlated with estrogen receptor (ER)-negative status and death at final follow-up. Patients with lower RBMS3 protein expression had substantially shorter survival than those with higher RBMS3 expression. Univariate and multivariate analysis indicated that the combination of RBMS3 expression and ER status (a variable designated as “cofactor”) was an independent prognostic factor in patients with breast cancer (hazard ratio [HR] = 0.420, 95% confidence interval [CI]: 0.223-0.791, P = 0.007). Conclusion: RBMS3 downregulation was correlated with poor prognosis in breast cancer patients, and the combination of RBMS3 expression and ER status was an independent prognostic factor.

scholarly journals ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor

2018 ◽  
Vol 50 (2) ◽  
pp. 495-505 ◽  
Author(s):  
Ji Won Lee ◽  
Sung Hye Park ◽  
Hyoung Jin Kang ◽  
Kyung Duk Park ◽  
Hee Young Shin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Alk Protein

scholarly journals Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2029
Author(s):  
Amer Abdulrahman ◽  
Markus Eckstein ◽  
Rudolf Jung ◽  
Juan Guzman ◽  
Katrin Weigelt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Cytokeratin 20 ◽  
Kaplan Meier ◽  
Increased Risk ◽  
Cox's Regression ◽  
Disease Specific

Prostate cancer, the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 protein expression in PCa by immunohistochemistry and to correlate the findings to the clinico-pathological data and prognosis. Immunohistochemical staining for GP88 was performed by TMA with samples from 442 PCa patients using an immunoreactive score (IRS). Altogether, 233 cases (52.7%) with negative GP88 staining (IRS < 2) and 209 cases (47.3%) with positive GP88 staining (IRS ≥ 2) were analyzed. A significant positive correlation was found for the GP88 IRS with the PSA value at prostatectomy and the cytoplasmic cytokeratin 20 IRS, whereas it was negatively associated with follow-up times. The association of GP88 staining with prognosis was further studied by survival analyses (Kaplan–Meier, univariate and multivariate Cox’s regression analysis). Increased GP88 protein expression appeared as an independent prognostic factor for overall, disease-specific and relapse-free survival in all PCa patients. Interestingly, in the subgroup of younger PCa patients (≤65 years), GP88 positivity was associated with a 3.8-fold (p = 0.004), a 6.0-fold (p = 0.008) and a 3.7-fold (p = 0.003) increased risk for death, disease-specific death and occurrence of a relapse, respectively. In the PCa subgroup with negative CK20 staining, GP88 positivity was associated with a 1.8-fold (p = 0.018) and a 2.8-fold increased risk for death and disease-specific death (p = 0.028). Altogether, GP88 protein positivity appears to be an independent prognostic factor for PCa patients.

scholarly journals Integrative Analysis Identified MCT4 as an Independent Prognostic Factor for Bladder Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Zhao ◽  
Bin Zhao ◽  
Wei-Hua Yan ◽  
Yan Xia ◽  
Zhi-Hui Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Protein Expression ◽  
Mrna Expression ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Radical Cystectomy ◽  
Independent Prognostic Factor ◽  
Bladder Cancer Cells ◽  
Glycolysis Process

BackgroundBladder cancer is the 10th most common cancer and most common urothelial malignancy worldwide. Prognostic biomarkers for bladder cancer patients are required for individualized treatment. Monocarboxylate transporter 4 (MCT4), encoded by SLC16A3 gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. We aimed to study the association between MCT4 expression and the overall survival (OS) of bladder cancer patients.MethodsThe published single-cell RNA sequencing data of 49,869 bladder cancer cells and 15,827 normal bladder mucosa cells and The Cancer Genome Atlas (TCGA) bladder cancer cohort data were used to explore the mRNA expression of SLC16A3 in bladder cancer. Eighty-nine consecutive bladder cancer patients who had undergone radical cystectomy were enrolled as a validation cohort. The expression of MCT4 proteins in bladder cancer specimens was detected using immunohistochemistry staining. The Kaplan–Meier survival analysis and Cox regression were performed to analyze the association between MCT4 protein expression and OS in bladder cancer patients.ResultsSLC16A3 mRNA was upregulated in bladder cancer cells. The upregulated genes in SLC16A3-positive epithelial cells were enriched in the glycolysis process pathway and monocarboxylic acid metabolic process pathway. Patients with high SLC16A3 mRNA expression showed significantly poor OS (p = 0.016). High MCT4 protein expression was also found to be an independent predictor for poor OS in bladder cancer patients (HR: 2.462; 95% CI: 1.202~5.042, p = 0.014). A nomogram was built based on the results of the multivariate Cox analysis.ConclusionBladder cancer with high SLC16A3 mRNA expression has a poor OS. High MCT4 protein expression is an independent prognostic factor for bladder cancer patients who had undergone radical cystectomy.

scholarly journals Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 38326-38336 ◽  
Author(s):  
Lars F. Petersen ◽  
Alexander C. Klimowicz ◽  
Shannon Otsuka ◽  
Anifat A. Elegbede ◽  
Stephanie K. Petrillo ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Protein Expression ◽  
Independent Prognostic Factor ◽  
Resected Nsclc ◽  
Atm Protein
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