scholarly journals Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

Oncotarget ◽  
2017 ◽  
Vol 8 (16) ◽  
pp. 27401-27411
Author(s):  
Yinchun Zhu ◽  
Lin Lin ◽  
Chao Wang ◽  
Haibo Jia ◽  
Sining Hu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Morphological Changes ◽  
Optical Coherence ◽  
Framingham Risk

Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography

2016 ◽  
Vol 27 (6) ◽  
pp. 460-466 ◽  
Author(s):  
Rocco Vergallo ◽  
Lei Xing ◽  
Yoshiyasu Minami ◽  
Tsunenari Soeda ◽  
Daniel S. Ong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Coronary Plaque ◽  
Optical Coherence ◽  
Framingham Risk

Abstract 17709: Framingham Risk Score and Coronary Plaque Characteristics as Assessed by Three-Vessel Optical Coherence Tomography Imaging

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Rocco Vergallo ◽  
Haibo Jia ◽  
Tsunenari Soeda ◽  
Yoshiyasu Minami ◽  
Sining Hu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Prediction Models ◽  
Coronary Plaque ◽  
Optical Coherence ◽  
Cholesterol Crystals ◽  
Coronary Syndrome ◽  
Framingham Risk ◽  
Risk Increase

Introduction: Clinical prediction models, such as the Framingham Risk Score (FRS), are useful to identify patients at high risk for future events. However, their association with coronary plaque features is largely unknown. Aim: This study aimed at evaluating the relationship between FRS and coronary plaque features by optical coherence tomography (OCT). Methods: FRS was assessed in 176 patients with coronary artery disease [72 with acute coronary syndrome (ACS), and 104 with stable angina] who underwent 3-vessel OCT imaging. Based on the FRS values, patients were divided into 3 groups: lower FRS (FRS<5%, n=26), intermediate FRS (5%≤FRS<10%, n=105), and higher FRS (FRS≥10%, n=45). Nonculprit coronary plaque features were compared among the 3 groups. Results: A total of 448 nonculprit plaques were identified (lower FRS, n=61; intermediate FRS, n=267; higher FRS, n=120). Compared to the patients with lower and intermediated FRS, those with higher FRS were older (p<0.001), and more likely to have male gender (p<0.001), diabetes (p=0.023), lower HDL-cholesterol (p<0.001) and higher creatinine levels (p=0.023). Compared to the patients with lower FRS, those with higher FRS had greater lipid index (mean lipid arc x lipid length), and tended to have higher prevalence of thin-cap fibroatheroma (TCFA). Patients with higher FRS showed greater prevalence of calcifications compared to those with lower and intermediate FRS. Prevalence of cholesterol crystals was progressively higher across the 3 groups. At multivariate analysis, presentation with ACS (OR, 2.37; 95% CI, 1.27–4.39; p=0.006), and FRS (OR, 1.57 per 5% risk increase; 95% CI, 1.01–2.42, p=0.043) were independent predictors of TCFA. Conclusions: Nonculprit plaques of patients with higher FRS showed greater lipid content, and higher prevalence of calcifications and cholesterol crystals compared to those of patients with lower and intermediate FRS. ACS presentation and FRS were independent predictors of TCFA.

STUDY OF HS-CRP IN PEOPLE OF HUE CITY

2015 ◽  
pp. 35-43
Author(s):  
Anh Tien Hoang ◽  
Kim Phuong Le
Keyword(s):  
Risk Factor ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Strong Predictor ◽  
High Sensitivity ◽  
Cerebrovascular Risk Factor ◽  
Framingham Risk ◽  
Cerebrovascular Risk ◽  
Hs Crp ◽  
Positive Significant Correlation

Background: High sensitivity C reactive protein is a protein that occur in acute phase of inflammation. hs-CRP is considered as a predict factor of cardiovascular and cerebrovascular risk. Framingham risk score is a strong predictor of cardiovascular and cerebrovascular risk and death. In Viet Nam there was still few studies about hs-CRP and Framingham risk score. Objective: To study the concentration of hs-CRP in peoples in Hue city, also the correlation of hs-CRP and cardiovascular and cerebrovascular risk factor, Framingham risk score. Methods: Clinical data of 1471 people age from 30-74 living in Hue city. We do clinical exam, paraclinical exam. We find out the correlations between hs-CRP and the cardiovascular and cerebrovascular risk factor, the correlations between hs-CRP and Framingham risk score. Results: (i) The concentration of hs-CRP of people in Hue city was 1.54 ± 3.81 mg/l. The concentration of hs-CRP in hyper cholesterol, hyper LDL, hypertension, smoke, obesity and hypo HDL group was significant higher than in the others groups (p<0.05). There was positive significant correlation between the concentration of hs-CRP and systolic blood pressure r=0.061(p< 0.05); (ii) There was positive significant correlation betwee the concentration of hs-CRP and cardiovascular risk (r=0.083; p<0.01) cerebrovascular risk (r=0.068; p<0.05). Conclusions: hs-CRP was a predict risk factor in cardiovascular and cerebrovascular. Key words: hs-CRP, Framingham, cardiovascular, cerebrovascular

The utility of coronary artery calcium in non-gated high resolution CT thorax scans in predicting cardiac events as compared to the Framingham risk score: a retrospective study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Saluja ◽  
H Contractor ◽  
M Daniells ◽  
J Sobolewska ◽  
K Khan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Retrospective Study ◽  
Coronary Artery ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Cardiac Events ◽  
End Point ◽  
Framingham Risk ◽  
Good Concordance

Abstract Background There is existing evidence to suggest a correlation between coronary artery calcification (CAC) measured using ECG-triggered chest computed tomography and cardiovascular disease. Further evidence has emerged to suggest a correlation between CAC measured using non-gated CT scans and cardiovascular disease. Herein, we sought to ascertain the utility of incidental findings of CAC on non-triggered high resolution CT (HRCT) thorax used for patients undergoing lung cancer screening or follow-up for interstitial lung disease and Framingham risk score (FRS) in predicting cardiovascular events. Methods The Computerised Radiology Information Service (CRIS) database was manually searched to determine all HRCT scans performed in a single trust from 05/2015 to 05/2016. The reports issued by Radiologists and images of selected studies were reviewed. For patients with CAC, we calculated the calcium score for patients using the Agatston method. Clinical events were determined from the electronic medical record without knowledge of patients' CAC findings. For these patients, the Framingham Risk Score (FRS) was also calculated. The primary end point of the study was composite of all-cause mortality and cardiac events (non-fatal myocardial infarction, coronary revascularization, new atrial fibrillation or heart failure episode requiring hospitalization). Results We selected 300 scans from a total of approximately 2000 scans performed over this time. Data at follow up was available for 100% of the patients, with a median duration of follow up of 1.6 years. Moderate to severe CAC was found in 35% of people. Multivariable analysis showed good concordance between CAC and FRS in predicting composite clinical end point. The Odds Ratio for cardiac events in patients with moderate to severe CAC was 5.3 (p&lt;0.01) and for composite clinical end point was 3.4 (p&lt;0.01). This is similar to the OR predicted by the FRS: 4.8; p&lt;0.01 and 3.1; p&lt;0.01 respectively. Only 6.2% of patients with moderate to severe CAC were currently statin treated. Conclusion In this retrospective study of patients with respiratory disease attending for HRCT scanning, co-incidentally detected CAC predicts cardiac events, with good concordance with the FRS. The incidental finding of CAC on non-gated CT scanning should be reported with Agatston score calculation allowing consideration of intervention to mitigate cardiovascular risk and optimize. Further multi-centre prospective studies of this strategy, with a larger patient cohort should be conducted to clarify the utility of CAC as a prediction tool to modify cardiac risk. Funding Acknowledgement Type of funding source: None

scholarly journals A Retrospective Exploratory Analysis on Cardiovascular Risk and Cognitive Dysfunction in Multiple Sclerosis

2021 ◽  
Vol 11 (4) ◽  
pp. 502
Author(s):  
Antonio Reia ◽  
Martina Petruzzo ◽  
Fabrizia Falco ◽  
Teresa Costabile ◽  
Matteo Conenna ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Verbal Learning ◽  
Macrovascular Disease ◽  
Cardiovascular Comorbidities ◽  
Cholesterol Levels ◽  
Framingham Risk ◽  
Input Variables

Background. Cardiovascular comorbidities have been associated with cognitive decline in the general population. Objectives. To evaluate the associations between cardiovascular risk and neuropsychological performances in MS. Methods. This is a retrospective study, including 69 MS patients. For all patients, we calculated the Framingham risk score, which provides the 10-year probability of developing macrovascular disease, using age, sex, diabetes, smoking, systolic blood pressure, and cholesterol levels as input variables. Cognitive function was examined with the Brief International Cognitive Assessment for MS (BICAMS), including the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-II (CVLT-II), and the Brief Visuospatial Memory Test-Revised (BVMT-R). Results. Each point increase of the Framingham risk score corresponded to 0.21 lower CVLT-II score. Looking at Framingham risk score components, male sex and higher total cholesterol levels corresponded to lower CVLT scores (Coeff = −8.54; 95%CI = −15.51, −1.57; and Coeff = −0.11; 95%CI = −0.20, −0.02, respectively). No associations were found between cardiovascular risk and SDMT or BVMT-R. Conclusions. In our exploratory analyses, cardiovascular risk was associated with verbal learning dysfunction in MS. Lifestyle and pharmacological interventions on cardiovascular risk factors should be considered carefully in the management of MS, given the possible effects on cognitive function.

Sign in / Sign up

Export Citation Format

Share Document