STUDY OF HS-CRP IN PEOPLE OF HUE CITY

2015 ◽  
pp. 35-43
Author(s):  
Anh Tien Hoang ◽  
Kim Phuong Le
Keyword(s):  
Risk Factor ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Strong Predictor ◽  
High Sensitivity ◽  
Cerebrovascular Risk Factor ◽  
Framingham Risk ◽  
Cerebrovascular Risk ◽  
Hs Crp ◽  
Positive Significant Correlation

Background: High sensitivity C reactive protein is a protein that occur in acute phase of inflammation. hs-CRP is considered as a predict factor of cardiovascular and cerebrovascular risk. Framingham risk score is a strong predictor of cardiovascular and cerebrovascular risk and death. In Viet Nam there was still few studies about hs-CRP and Framingham risk score. Objective: To study the concentration of hs-CRP in peoples in Hue city, also the correlation of hs-CRP and cardiovascular and cerebrovascular risk factor, Framingham risk score. Methods: Clinical data of 1471 people age from 30-74 living in Hue city. We do clinical exam, paraclinical exam. We find out the correlations between hs-CRP and the cardiovascular and cerebrovascular risk factor, the correlations between hs-CRP and Framingham risk score. Results: (i) The concentration of hs-CRP of people in Hue city was 1.54 ± 3.81 mg/l. The concentration of hs-CRP in hyper cholesterol, hyper LDL, hypertension, smoke, obesity and hypo HDL group was significant higher than in the others groups (p<0.05). There was positive significant correlation between the concentration of hs-CRP and systolic blood pressure r=0.061(p< 0.05); (ii) There was positive significant correlation betwee the concentration of hs-CRP and cardiovascular risk (r=0.083; p<0.01) cerebrovascular risk (r=0.068; p<0.05). Conclusions: hs-CRP was a predict risk factor in cardiovascular and cerebrovascular. Key words: hs-CRP, Framingham, cardiovascular, cerebrovascular

The Association between Prolactin, High-Sensitivity C-Reactive Protein and Framingham Risk Score in Menopause

2014 ◽  
Vol 78 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Elif Didem Ozdemir ◽  
Gamze Sinem Caglar ◽  
Ebru Akgul ◽  
Sevim Dincer Cengiz ◽  
Gamze Tombak
Keyword(s):  
Risk Score ◽  
Framingham Risk Score ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Framingham Risk

scholarly journals Cardio-ankle vascular index as an arterial stiffness marker improves on cardiovascular events by adding to framingham risk score

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Ono ◽  
T Miyoshi ◽  
Y Ohno ◽  
Y Ueki ◽  
K Kuroda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Risk Score ◽  
Cardiovascular Events ◽  
Framingham Risk Score ◽  
Risk Group ◽  
Independent Predictor ◽  
Intermediate Risk ◽  
Framingham Risk

Abstract Background The cardio-ankle vascular index (CAVI) is a non-invasive measurement that evaluates arterial stiffness using the analysis of oscillometric waveform during cuff-Inflation. Several studies reported that CAVI is associated with cardiovascular risk factors, while the clinical prognostic value of CAVI as a surrogate marker of atherosclerosis has not been fully elucidated. Meanwhile, the Framingham risk score (FRS) is an established marker of cardiovascular outcomes. Purpose To investigate whether adding CAVI to Framingham risk score improves the prediction of cardiovascular events. Methods This prospective observational study included consecutive 422 patients with cardiovascular risk factors but without known coronary artery disease (69±8 years, 63% men). CAVI was measured by the oscillometric method with VaSera vascular screening system. Patients with atrial fibrillation, left ventricular ejection fraction &lt;50%, both ABI&lt;0.9, severe valvular diseases, or hemodialysis were excluded. Primacy outcomes were cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure and revascularization. Results During a median follow-up of 3.1 years, cardiovascular events occurred in 12.8% (3.3%, 15.7%, and 19.1% in the low, intermediate and high-risk group of stratification by FRS, respectively). The ROC curve analysis for discriminating cardiovascular events showed that the AUC of CAVI added to Framingham risk score was the highest compared to Framingham risk score and CAVI alone (CAVI added to Framingham risk score: AUC 66.9, 95% CI 59.6–74.2, Framingham risk score alone: AUC 61.5, 95% CI 53.8–69.1, CAVI alone: AUC 62.3, 95% CI 54.1–70.6). The logistic regression analysis demonstrated that CAVI and Framingham risk score were independent predictors of cardiovascular events (CAVI: OR 1.381, 95% CI 1.164–1.597, p=0.004, Framingham risk score: OR 1.135, 95% CI 1.044–1.225, p=0.007). Next, when logistic regression analysis was performed simultaneously on Framingham risk factor and CAVI, CAVI was an independent predictor of cardiovascular events (OR 1.347, 95% CI 1.124–1.569, p=0.009). Furthermore, in the likelihood ratio test, CAVI added to Framingham risk score significantly improved the cardiovascular event prediction ability than Framingham risk factor alone. Next, when patients with intermediate risk (n=217) were divided into two groups based on CAVI of 9.0, the Kaplan-Meier estimate showed that events occurred more frequently in higher CAVI group (9.3% and 29.1%, log-rank, P=0.009) and the C-statistic was 0.662. Multiple Cox analysis showed that, in the intermediate risk group, CAVI was an independent predictor of primary outcomes (HR 1.387 per 1 index, 95% CI 1.081–1.779, p=0.010). Conclusion The measurement of CAVI could be a useful predictor for cardiovascular events. In addition, the combination of CAVI and Framingham risk score could improve the predictability compared to the Framingham risk score alone. Funding Acknowledgement Type of funding source: None

Abstract P010: Cardiac Risk Factors and 6-Year Change in high-sensitivity Cardiac Troponin-T.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Bill McEvoy ◽  
Mariana Lazo-Elizondo ◽  
Lu Shen ◽  
Vijay Nambi ◽  
Ron Hoogeveen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Troponin T ◽  
Myocardial Damage ◽  
High Sensitivity ◽  
Cardiac Risk ◽  
Cardiac Risk Factors ◽  
Framingham Risk ◽  
Study Participants

Introduction: Troponin measured with a highly sensitive assay (hs-cTNT) can detect subclinical myocardial injury and may be useful for risk stratification. However, little is known about temporal changes in hs-cTNT in the general population. Hypothesis: Traditional cardiac risk factors will predict change in hs cTNT. Methods: We analyzed data from 8698 ARIC Study participants, free of cardiovascular disease, who had hs-cTNT measured at visit 2 (1990-1992) and visit 4 (1996-1998). Hs-cTNT was categorized as: undetectable (<5 ng/L), detectable (5-14 ng/L), and elevated (≥14 ng/L). We examined the association of baseline Framingham Risk Score (FRS) groups (low <10%, intermediate 10-20%, high >20%) and individual cardiac risk factors with change across hs-cTNT categories using Poisson regression and with absolute 6-year change using robust linear regression. Results: Over 6 years, 2124 study participants went from undetectable to detectable or elevated hs-cTNT and 353 went from detectable to elevated hs-cTNT. The mean crude 6-year hs-cTNT change (SD) within FRS groups were; low (+1.3 (6.0) ng/L), intermediate (+2.3 (9.3) ng/L), and high (+3.7 (8.3) ng/L). Higher baseline FRS was associated with an increase in hs-cTNT over 6 years ( Table ). This association was stronger for incident detectable hs-cTNT than for progression from detectable to elevated. Major predictors of change were baseline age, male gender, diabetes and hypertension. Black race/ethnicity and obesity were also associated with categorical hs-cTNT change. In addition to HDL-c, baseline hypercholesterolemia and smoking may be associated with downwards hs-cTNT change. Conclusions: Framingham Risk Score was positively associated with 6-year hs-cTNT change in middle-age adults. The modifiable risk factors primarily driving this association were diabetes, hypertension, and obesity. Additional studies are needed to evaluate if modifying these risk factors can prevent progression of subclinical myocardial damage.

scholarly journals Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

2016 ◽  
Vol 23 (9) ◽  
pp. 1138-1139 ◽  
Author(s):  
Kunihiro Nishimura ◽  
Tomonori Okamura ◽  
Makoto Watanabe ◽  
Michikazu Nakai ◽  
Misa Takegami ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Risk Score ◽  
Urban Population ◽  
Framingham Risk Score ◽  
Framingham Risk

scholarly journals Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

2014 ◽  
Vol 21 (8) ◽  
pp. 784-798 ◽  
Author(s):  
Kunihiro Nishimura ◽  
Tomonori Okamura ◽  
Makoto Watanabe ◽  
Michikazu Nakai ◽  
Misa Takegami ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Risk Score ◽  
Urban Population ◽  
Framingham Risk Score ◽  
Framingham Risk

Abstract 3299: Association Of The Metabolic Syndrome, Diabetes And Framingham Risk Score With Coronary Artery Calcium

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Uzoma N Ibebuogu ◽  
nathan D Wong ◽  
Jessica Ramirez ◽  
SongShou Mao ◽  
Fereshteh Hajsadeghi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Coronary Artery ◽  
Risk Score ◽  
Coronary Artery Calcium ◽  
Framingham Risk Score ◽  
Subclinical Atherosclerosis ◽  
The Metabolic Syndrome ◽  
Framingham Risk ◽  
Risk Factor Burden

INTRODUCTION: Coronary artery calcium (CAC) is a sensitive marker for the detection of subclinical coronary heart disease (CHD), and can be accurately quantified using cardiac computed tomography. Few studies have examined the relation between the metabolic syndrome (MetS), MetS risk factor burden, diabetes, and CAC. HYPOTHESIS: To examine the relation between MetS, as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), MetS risk factor burden, diabetes and CAC. METHODS: We studied 356 consecutive, asymptomatic men and women aged 58 ± 11 years who underwent CAC testing, 116 had MetS, 61 had diabetes, and the remainder had neither. MetS was defined according to the NCEP ATP III guidelines with ≥ 3 risk factors. The prevalence and odds of CAC among these groups were determined by multivariable logistic regression analysis. Receiver operating characteristic curves were used to determine if MetS or diabetes added to 10-year CHD estimated by the Framingham risk score (FRS) in predicting CAC. RESULTS: The prevalence of CAC >0 for those with diabetes, MetS and neither condition was 73%, 69% and 60% respectively, while the prevalence of CAC ≥ 100 for the 3 groups was 64%, 43% and 24% respectively. Risk factor-adjusted odds for the presence of CAC ≥ 100 were 2.26 (95% CI 1 to 4.4, p=0.0001) among those with MetS and 3.46 (95% CI 1.6 to 7.4, p=0.0001) among those with diabetes, versus neither condition. ROC analysis for CAC ≥ 100 showed an area under the curve of 0.61 (95% CI 0.54 – 0.68) for FRS, 0.72 (95% CI 0.61– 0.83) for diabetes, 0.67 (95% CI 0.56 – 0.77) for the metabolic syndrome, 0.78 (95% CI 0.7– 0.85) when the MetS is added to the FRS (p<0.0001 compared to FRS alone), and 0.90 (95% CI 0.85– 0.95) when diabetes is added to the FRS (p<0.0001 compared to FRS alone). The CAC score showed a trend towards a progressive increase across the metabolic score ranging from 0 to 5 (p=0.0001). CONCLUSIONS: Those with MetS or diabetes have an increased likelihood of subclinical atherosclerosis (measured by CAC) compared to those with neither condition, and they also add to prediction of CAC over FRS, suggesting the importance of these factors in clinical assessment of CHD risk.

scholarly journals Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women

2008 ◽  
Vol 295 (3) ◽  
pp. H931-H938 ◽  
Author(s):  
Muthuvel Jayachandran ◽  
Robert D. Litwiller ◽  
Whyte G. Owen ◽  
John A. Heit ◽  
Thomas Behrenbeck ◽  
...  
Keyword(s):  
Risk Score ◽  
Framingham Risk Score ◽  
Total Concentration ◽  
High Sensitivity ◽  
Coronary Calcification ◽  
Low Risk ◽  
Cross Sectional ◽  
Framingham Risk ◽  
Menopausal Women

While the risk for symptomatic atherosclerotic disease increases after menopause, currently recognized risk factors do not identify ongoing disease processes in low-risk women. This study tested the hypothesis that circulating cell-derived microparticles may reflect disease processes in women defined as low risk by the Framingham risk score. The concentration and phenotype of circulating microparticles were evaluated in a cross-sectional study of apparently healthy menopausal women, screened for enrollment into the Kronos Early Estrogen Prevention Study. Microparticles were evaluated by flow cytometry, and coronary artery calcification (CAC) was scored using 64-slice computed tomography scanners. The procoagulant activity of isolated microparticles was determined with a sensitive fluorescent thrombin generation assay. Chronological age, body mass index, serum lipids, systolic blood pressure (Framingham risk score < 10%, range 1–3%), and high-sensitivity C-reactive protein did not differ significantly among women with low (0 < 35; range, 0.3–32 Agatston units) or high (>50; range, 93–315 Agatston units) CAC compared with women without calcification. The total concentration and percentage of microparticles derived from platelets and endothelial cells were greatest in women with high CAC scores. The thrombin-generating capacity of the isolated microparticles correlated with phosphatidylserine expression, which also was greatest in women with high CAC scores. The percentages of microparticles expressing granulocyte and monocyte markers were not significantly different among groups. Therefore, the characterization of platelet and endothelial microparticles may identify early menopausal women with premature CAC who would not otherwise be identified by the usual risk factor analysis.

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