scholarly journals Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma

Oncotarget ◽  
2014 ◽  
Vol 5 (2) ◽  
pp. 506-518 ◽  
Author(s):  
Nicole M.A. White ◽  
Olena Masui ◽  
Leroi V. DeSouza ◽  
Olga Krakovska ◽  
Shereen Metias ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Diagnostic Markers ◽  
Quantitative Proteomic Analysis

Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma

PROTEOMICS ◽  
2008 ◽  
Vol 8 (15) ◽  
pp. 3194-3203 ◽  
Author(s):  
Noboru Okamura ◽  
Taro Masuda ◽  
Akinobu Gotoh ◽  
Toshiro Shirakawa ◽  
Shuji Terao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Therapeutic Targets ◽  
Diagnostic Markers ◽  
Human Renal Cell Carcinoma ◽  
Quantitative Proteomic Analysis

Label-free quantitative proteomic analysis reveals potential biomarkers and pathways in renal cell carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 939-951 ◽  
Author(s):  
Zuohui Zhao ◽  
Fei Wu ◽  
Sentai Ding ◽  
Liang Sun ◽  
Zhao Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Label Free ◽  
Quantitative Proteomic Analysis ◽  
Potential Biomarkers

scholarly journals iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yushi Zhang ◽  
Yi Cai ◽  
Hongyan Yu ◽  
Hanzhong Li
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Early Stage ◽  
Characteristic Curve ◽  
Serum Biomarker ◽  
Control Group ◽  
Serum Samples ◽  
Quantitative Proteomic Analysis

Renal cell carcinoma (RCC) is one of the most lethal urologic cancers and about 80% of RCC are of the clear-cell type (ccRCC). However, there are no serum biomarkers for the accurate diagnosis of RCC. In this study, we performed a quantitative proteomic analysis on serum samples from ccRCC patients and control group by using isobaric tag for relative and absolute quantitation (iTRAQ) labeling and LC-MS/MS analysis to access differentially expressed proteins. Overall, 16 proteins were significantly upregulated (ratio > 1.5) and 14 proteins were significantly downregulated (ratio < 0.67) in early-stage ccRCC compared to control group. HSC71 was selected and subsequently validated by Western blot in six independent sets of patients. ELISA subsequently confirmed HSC71 as a potential serum biomarker for distinguishing RCC from benign urologic disease with an operating characteristic curve (ROC) area under the curve (AUC) of 0.86 (95% confidence interval (CI), 0.76~0.96), achieving sensitivity of 87% (95% CI 69%~96%) at a specificity of 80% (95% CI 61~92%) with a threshold of 15 ng/mL. iTRAQ-based quantitative proteomic analysis led to identification of serum HSC71 as a novel serum biomarker of RCC, particularly useful in early diagnosis of ccRCC.

scholarly journals Identification of Proteins Differentially Expressed in the Conventional Renal Cell Carcinoma by Proteomic Analysis

2005 ◽  
Vol 20 (3) ◽  
pp. 450 ◽  
Author(s):  
Jeong Seok Hwa ◽  
Hyo Jin Park ◽  
Jae Hun Jung ◽  
Sung Chul Kam ◽  
Hyung Chul Park ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Differentially Expressed ◽  
Conventional Renal Cell Carcinoma

Differential Radioactive Proteomic Analysis of Microdissected Renal Cell Carcinoma Tissue by 54 cm Isoelectric Focusing in Serial Immobilized pH Gradient Gels

2005 ◽  
Vol 4 (6) ◽  
pp. 2117-2125 ◽  
Author(s):  
Slobodan Poznanović ◽  
Wojciech Wozny ◽  
Gerhard P. Schwall ◽  
Chaturvedula Sastri ◽  
Christian Hunzinger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Isoelectric Focusing ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Ph Gradient ◽  
Carcinoma Tissue ◽  
Renal Cell Carcinoma Tissue

Proteomic analysis in clear cell renal cell carcinoma: identification of differentially expressed protein by 2-D DIGE

2012 ◽  
Vol 8 (4) ◽  
pp. 1040 ◽  
Author(s):  
Francesca Raimondo ◽  
Claudia Salemi ◽  
Clizia Chinello ◽  
Daniela Fumagalli ◽  
Lavinia Morosi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Clear Cell ◽  
Differentially Expressed ◽  
Cell Renal Cell Carcinoma ◽  
Differentially Expressed Protein
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