Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma

PROTEOMICS ◽  
2008 ◽  
Vol 8 (15) ◽  
pp. 3194-3203 ◽  
Author(s):  
Noboru Okamura ◽  
Taro Masuda ◽  
Akinobu Gotoh ◽  
Toshiro Shirakawa ◽  
Shuji Terao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Therapeutic Targets ◽  
Diagnostic Markers ◽  
Human Renal Cell Carcinoma ◽  
Quantitative Proteomic Analysis

scholarly journals Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma

Oncotarget ◽  
2014 ◽  
Vol 5 (2) ◽  
pp. 506-518 ◽  
Author(s):  
Nicole M.A. White ◽  
Olena Masui ◽  
Leroi V. DeSouza ◽  
Olga Krakovska ◽  
Shereen Metias ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Diagnostic Markers ◽  
Quantitative Proteomic Analysis

scholarly journals Metabolism-related enzyme alterations identified by proteomic analysis in human renal cell carcinoma

2016 ◽  
pp. 1327 ◽  
Author(s):  
Yuqin Yao ◽  
Zejun Lu ◽  
Qi Song ◽  
Jinliang Yang ◽  
Xiangfei Zhao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Human Renal Cell Carcinoma ◽  
Related Enzyme

Label-free quantitative proteomic analysis reveals potential biomarkers and pathways in renal cell carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 939-951 ◽  
Author(s):  
Zuohui Zhao ◽  
Fei Wu ◽  
Sentai Ding ◽  
Liang Sun ◽  
Zhao Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Label Free ◽  
Quantitative Proteomic Analysis ◽  
Potential Biomarkers

scholarly journals iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yushi Zhang ◽  
Yi Cai ◽  
Hongyan Yu ◽  
Hanzhong Li
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Early Stage ◽  
Characteristic Curve ◽  
Serum Biomarker ◽  
Control Group ◽  
Serum Samples ◽  
Quantitative Proteomic Analysis

Renal cell carcinoma (RCC) is one of the most lethal urologic cancers and about 80% of RCC are of the clear-cell type (ccRCC). However, there are no serum biomarkers for the accurate diagnosis of RCC. In this study, we performed a quantitative proteomic analysis on serum samples from ccRCC patients and control group by using isobaric tag for relative and absolute quantitation (iTRAQ) labeling and LC-MS/MS analysis to access differentially expressed proteins. Overall, 16 proteins were significantly upregulated (ratio > 1.5) and 14 proteins were significantly downregulated (ratio < 0.67) in early-stage ccRCC compared to control group. HSC71 was selected and subsequently validated by Western blot in six independent sets of patients. ELISA subsequently confirmed HSC71 as a potential serum biomarker for distinguishing RCC from benign urologic disease with an operating characteristic curve (ROC) area under the curve (AUC) of 0.86 (95% confidence interval (CI), 0.76~0.96), achieving sensitivity of 87% (95% CI 69%~96%) at a specificity of 80% (95% CI 61~92%) with a threshold of 15 ng/mL. iTRAQ-based quantitative proteomic analysis led to identification of serum HSC71 as a novel serum biomarker of RCC, particularly useful in early diagnosis of ccRCC.

MP-5.04: Proteomic Analysis for Human Renal Cell Carcinoma Cell Clones Having Different Metastatic Potentials

Urology ◽  
2008 ◽  
Vol 72 (5) ◽  
pp. S92-S93
Author(s):  
Y. Kuramitsu ◽  
T. Tanaka ◽  
M. Fujimoto ◽  
S. Naito ◽  
M. Oka ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proteomic Analysis ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Human Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell ◽  
Cell Clones
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