scholarly journals Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (16) ◽  
pp. 26041-26056 ◽  
Author(s):  
Adeola O. Adebayo Michael ◽  
Nagib Ahsan ◽  
Valerie Zabala ◽  
Heather Francois-Vaughan ◽  
Stephanie Post ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rat Model ◽  
Proteomic Analysis ◽  
Focal Lesions ◽  
Laser Capture ◽  
Laser Capture Microdissected

scholarly journals Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli

2012 ◽  
Vol 25 (5) ◽  
pp. 709-721 ◽  
Author(s):  
Anjali A Satoskar ◽  
John P Shapiro ◽  
Cherri N Bott ◽  
Huijuan Song ◽  
Gyongyi M Nadasdy ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Glomerular Diseases ◽  
Laser Capture ◽  
Laser Capture Microdissected

Proteomic analysis of immunostained, laser-capture microdissected brain samples

2003 ◽  
Vol 24 (12) ◽  
pp. 296-302 ◽  
Author(s):  
Lionel Moulédous ◽  
Sybille Hunt ◽  
Rebecca Harcourt ◽  
Jenny L. Harry ◽  
Keith L. Williams ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Laser Capture ◽  
Laser Capture Microdissected

Proteomic analysis of laser capture microdissected human prostate cancer andin vitro prostate cell lines

2000 ◽  
Vol 21 (11) ◽  
pp. 2235-2242 ◽  
Author(s):  
David K. Ornstein ◽  
John W. Gillespie ◽  
Cloud P. Paweletz ◽  
Paul H. Duray ◽  
Judi Herring ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Proteomic Analysis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cell ◽  
Laser Capture ◽  
Prostate Cell Lines ◽  
Laser Capture Microdissected

Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

2020 ◽  
Vol 20 (5) ◽  
pp. 382-389 ◽  
Author(s):  
Shimaa EL-Sharawy ◽  
Osama El- Sayed Negm ◽  
Sherief Abd-Elsalam ◽  
Hesham Ahmed EL-Sorogy ◽  
Mona Ahmed Helmy Shehata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Gene Polymorphism ◽  
Clinical Laboratory ◽  
Treatment Options ◽  
Laboratory Evaluation ◽  
Toll Like Receptor ◽  
Focal Lesions ◽  
Tlr3 Gene ◽  
Cirrhotic Patients

Background & Aims: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the development of cancers. This study aimed to investigate the association between TLR3 gene polymorphism and HCV-related hepatocellular carcinoma in Egypt. Methods: This work was conducted on 70 individuals; fifty HCV cirrhotic patients were included in two groups; with HCC (30 patients) and without HCC (20 patients) compared with a group of 20 apparently healthy controls. All of the studied individuals underwent clinical-laboratory evaluation. TLR3 gene single-nucleotide polymorphism (SNP) (+1234C/T) was tested by polymerase chain reaction- restriction fragment length polymorphism. Results: This study reported that the prevalence of TLR3 +1234TT genotype was significantly increased in cirrhotic patients with HCC than without HCC, while it was not detected at all among the controls. When analyzing the TLR3 SNP +1234C/T with different clinical parameters in HCC patients, there was a significant association between+1234C/T SNP; namely TT genotype and each of the hepatic focal lesions᾽ number, size and the patients᾽ higher Okuda and BCLC stages. No association could be detected between TLR3 SNP and the age, sex, Child-Pugh grades, MELD score or AFP of the studied HCC cases. Conclusion: TLR3 gene SN P +1234C/T could be a novel risk factor for the HCV-related HCC among the Egyptian population.

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