Telomere length-related geneACYP2polymorphism is associated with the risk of HAPE in Chinese Han population

2016 ◽  
Vol 18 (9) ◽  
pp. 244-249 ◽  
Author(s):  
Yongjun He ◽  
Xiyang Zhang ◽  
Xun Li ◽  
Jieli Du ◽  
Xue He ◽  
...  
Keyword(s):  
Telomere Length ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 9849-9857 ◽  
Author(s):  
Fang Liu ◽  
Zhongguo Zhang ◽  
Yong Zhang ◽  
Yue Chen ◽  
Xiaoyu Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Telomere Length ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Related Gene ◽  
Chinese Han ◽  
Han Population

scholarly journals Polymorphisms in Telomere Length Associated TERC and TERT predispose for Ischemic Stroke in a Chinese Han population

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shuo Zhang ◽  
Guofa Ji ◽  
Yiqian Liang ◽  
Rui Zhang ◽  
Puyu Shi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Telomere Length ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Relative Telomere Length and Stroke Risk in a Chinese Han Population

2018 ◽  
Vol 66 (4) ◽  
pp. 475-481 ◽  
Author(s):  
Dan Gao ◽  
Rui Zhang ◽  
Guofa Ji ◽  
Chunqi Li ◽  
Dangshe Guo ◽  
...  
Keyword(s):  
Telomere Length ◽  
Stroke Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Relative Telomere Length

scholarly journals Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population

2011 ◽  
Vol 19 (6) ◽  
pp. 721-723 ◽  
Author(s):  
Qin Shen ◽  
Zhou Zhang ◽  
Lan Yu ◽  
Lan Cao ◽  
DaiZhan Zhou ◽  
...  
Keyword(s):  
Telomere Length ◽  
Chinese Han Population ◽  
Leukocyte Telomere Length ◽  
Common Variants ◽  
Chinese Han ◽  
Han Population

scholarly journals Single nucleotide polymorphisms in telomere length-related genes are associated with hepatocellular carcinoma risk in the Chinese Han population

2020 ◽  
Vol 12 ◽  
pp. 175883592093302
Author(s):  
Peng Huang ◽  
Rong Li ◽  
Lin Shen ◽  
Weizhou He ◽  
Shuo Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphisms ◽  
Telomere Length ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Frequency Distributions ◽  
Han Population ◽  
Tert Gene

Background: Single nucleotide polymorphisms (SNPs) in telomere-related genes are associated with a high risk of hepatocellular carcinoma (HCC). In this study, we investigated the SNPs of telomere length-related genes and their correlation with HCC risk in the Chinese Han population. Materials and methods: A total of 473 HCC patients and 564 healthy volunteers were recruited. Overall, 42 SNPs distributed in telomere-related genes were selected and identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: We found rs6713088 (OR = 1.27, 95% CI = 1.07–1.52, p = 0.007), rs843711 (OR = 1.29, 95% CI = 1.09–1.54, p = 0.004) and rs843706 (OR = 1.30, 95% CI = 1.09–1.55, p = 0.003) in the ACYP2 gene, rs10936599 (OR = 1.21, 95% CI = 1.02–1.44, p = 0.032) in the TERC gene and rs7708392 (OR = 1.24, 95% CI = 1.00–1.52, p = 0.042) in the TNIP1 gene were associated with high HCC risk (OR > 1). In contrast, rs1682111 (OR = 0.77, 95% CI = 0.64–0.94, p = 0.008) in the ACYP2 gene, rs2320615 (OR = 0.79, 95% CI = 0.64–0.99, p = 0.038) in the NAF1 gene, rs10069690 (OR = 0.75, 95% CI = 0.59–0.96, p = 0.021) and rs2242652 (OR = 0.70, 95% CI = 0.55–0.90, p = 0.004) in the TERT gene were associated with low HCC risk (OR < 1). Based on genotype frequency distributions, rs6713088, rs843645, rs843711 and rs843706 located in the ACYP2 gene as well as rs10936599 in the TERC gene were associated with a high incidence of HCC ( p < 0.05). In addition, SNPs in these genes could form a linkage imbalance haplotype. Specifically, the haploid ‘GC’ formed by rs10069690 and rs2242652 within the TERT gene increased the risk of HCC ( p < 0.05). Conclusion: SNPs in ACYP2, TERC, TERT and other genes were correlated with HCC risk in the Chinese Han population. These data may provide new insights into early diagnosis and screening of HCC.

Constitutive telomere length and gastric cancer risk: Case-control analysis in Chinese Han population

2009 ◽  
Vol 100 (7) ◽  
pp. 1300-1305 ◽  
Author(s):  
Xiaonan Liu ◽  
Guoqiang Bao ◽  
Tingting Huo ◽  
Zizhong Wang ◽  
Xianli He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Case Control ◽  
Chinese Han Population ◽  
Control Analysis ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population ◽  
Case Control Analysis

scholarly journals Association analysis of telomere length related gene ACYP2 with the gastric cancer risk in the northwest Chinese Han population

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 31144-31152 ◽  
Author(s):  
Jianhui Li ◽  
Gang Ma ◽  
Xulong Zhu ◽  
Tianbo Jin ◽  
Jianxiong Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Association Analysis ◽  
Chinese Han Population ◽  
Related Gene ◽  
Gastric Cancer Risk ◽  
Chinese Han ◽  
Han Population
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