scholarly journals Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation

Oncotarget ◽  
2016 ◽  
Vol 7 (45) ◽  
pp. 73229-73241 ◽  
Author(s):  
Lei Wang ◽  
Yang Chen ◽  
Xiang Li ◽  
Youzhi Zhang ◽  
Erich Gulbins ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Nlrp3 Inflammasome ◽  
Cathepsin B ◽  
Endothelial Permeability ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Shengnan Zhao ◽  
Zizhen Gong ◽  
Xixi Du ◽  
Chunyan Tian ◽  
Lingyu Wang ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
High Fat Diet ◽  
Cathepsin B ◽  
Intestinal Inflammation ◽  
Critical Role ◽  
Inflammasome Activation ◽  
High Fat ◽  
Molecular Pattern ◽  
Nlrp3 Inflammasome Activation ◽  
Sphingosine 1 Phosphate

We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated through bile acid receptor sphingosine-1-phosphate receptor 2 (S1PR2); however, the intermediate process remains unclear. Here, we sought to explore the detailed molecular mechanism involved and examine the effect of S1PR2 blockage in a colitis mouse model. In this study, we found that DCA could dose dependently upregulate S1PR2 expression. Meanwhile, DCA-induced NLRP3 inflammasome activation is at least partially achieved through stimulating extracellular regulated protein kinases (ERK) signaling pathway downstream of S1PR2 followed by promoting of lysosomal cathepsin B release. DCA enema significantly aggravated DSS-induced colitis in mice and S1PR2 inhibitor as well as inflammasome inhibition by cathepsin B antagonist substantially reducing the mature IL-1β production and alleviated colonic inflammation superimposed by DCA. Therefore, our findings suggest that S1PR2/ERK1/2/cathepsin B signaling plays a critical role in triggering inflammasome activation by DCA and S1PR2 may represent a new potential therapeutic target for the management of intestinal inflammation in individuals on a high-fat diet.

scholarly journals Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

2020 ◽  
Vol 8 ◽  
Author(s):  
Angélique Chevriaux ◽  
Thomas Pilot ◽  
Valentin Derangère ◽  
Harmonie Simonin ◽  
Pierre Martine ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Cathepsin B ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

2015 ◽  
Vol 125 (2) ◽  
pp. 665-680 ◽  
Author(s):  
Jong-Seok Moon ◽  
Seonmin Lee ◽  
Mi-Ae Park ◽  
Ilias I. Siempos ◽  
Maria Haslip ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nlrp3 Inflammasome ◽  
Fatty Acid Synthase ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation
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