scholarly journals UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

2015 ◽  
Vol 125 (2) ◽  
pp. 665-680 ◽  
Author(s):  
Jong-Seok Moon ◽  
Seonmin Lee ◽  
Mi-Ae Park ◽  
Ilias I. Siempos ◽  
Maria Haslip ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nlrp3 Inflammasome ◽  
Fatty Acid Synthase ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 924
Author(s):  
Ni-Chun Kuo ◽  
Shieh-Yang Huang ◽  
Chien-Yi Yang ◽  
Hsin-Hsueh Shen ◽  
Yen-Mei Lee
Keyword(s):  
Hepatic Steatosis ◽  
Nlrp3 Inflammasome ◽  
Hepg2 Cells ◽  
Fatty Acid Synthase ◽  
Heme Oxygenase 1 ◽  
Autophagic Flux ◽  
Inflammasome Activation ◽  
Related Factor ◽  
Nlrp3 Inflammasome Activation ◽  
Wide Range

Magnolol (MG) is the main active compound of Magnolia officinalis and exerts a wide range of biological activities. In this study, we investigated the effects of MG using tyloxapol (Tylo)-induced (200 mg/kg, i.p.) hyperlipidemia in rats and palmitic acid (PA)-stimulated (0.3 mM) HepG2 cells. Our results showed that Tylo injection significantly increased plasma levels of triglyceride and cholesterol as well as superoxide anion in the livers, whereas MG pretreatment reversed these changes. MG reduced hepatic lipogenesis by attenuating sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) proteins and Srebp-1, Fas, Acc, and Cd36 mRNA expression as well as upregulated the lipolysis-associated genes Hsl, Mgl, and Atgl. Furthermore, MG reduced plasma interleukin-1β (IL-1β) and protein expression of NLR family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and caspase 1 as well as upregulated nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and induction of heme oxygenase-1 (HO-1) in hepatocytes of Tylo-treated rats. Enhanced autophagic flux by elevation of autophagy related protein 5-12 (ATG5-12), ATG7, Beclin1, and microtubule-associated protein light chain 3 B II (LC3BII)/LC3BI ratio, and reduction of sequestosome-1 (SQSTM1/p62) and phosphorylation of mTOR was observed by MG administration. However, autophagy inhibition with 3-methyladenine (3-MA) in HepG2 cells drastically abrogated the MG-mediated suppression of inflammation and lipid metabolism. In conclusion, MG inhibited hepatic steatosis-induced NLRP3 inflammasome activation through the restoration of autophagy to promote HO-1 signaling capable of ameliorating oxidative stress and inflammatory responses.

scholarly journals PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages

2019 ◽  
Vol 43 (5) ◽  
pp. 683
Author(s):  
Seung Il Jo ◽  
Jung Hwan Bae ◽  
Seong Jin Kim ◽  
Jong Min Lee ◽  
Ji Hun Jeong ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Antidiabetic Agent ◽  
Nlrp3 Inflammasome Activation

scholarly journals NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

2016 ◽  
Vol 22 (9) ◽  
pp. 1002-1012 ◽  
Author(s):  
Jong-Seok Moon ◽  
Kiichi Nakahira ◽  
Kuei-Pin Chung ◽  
Gina M DeNicola ◽  
Michael Jakun Koo ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Nlrp3 Inflammasome ◽  
Acid Oxidation ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation
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