scholarly journals Primary and recurrent ovarian high-grade serous carcinomas display similar microRNA expression patterns relative to those of normal ovarian tissue

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 70524-70534 ◽  
Author(s):  
Eun Ji Nam ◽  
Sunghoon Kim ◽  
Taek Sang Lee ◽  
Hee Jung Kim ◽  
Jung Yun Lee ◽  
...  
Keyword(s):  
Ovarian Tissue ◽  
Expression Patterns ◽  
Microrna Expression ◽  
High Grade ◽  
Normal Ovarian Tissue

scholarly journals Chromosome Unipolar Division and Low Expression of Tws May Cause Parthenogenesis of Rice Water Weevil (Lissorhoptrus oryzophilus Kuschel)

Insects ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 278
Author(s):  
Pengcheng Wang ◽  
Fangyuan Yang ◽  
Zhuo Ma ◽  
Runzhi Zhang
Keyword(s):  
Drosophila Melanogaster ◽  
Quantitative Pcr ◽  
Ovarian Tissue ◽  
Expression Patterns ◽  
Meiotic Spindle ◽  
Lissorhoptrus Oryzophilus ◽  
Rice Water Weevil ◽  
Rice Water ◽  
Beijing China ◽  
Low Expression

Rice water weevil (RWW) is divided into two types of population, triploid parthenogenesis and diploid bisexual reproduction. In this study, we explored the meiosis of triploid parthenogenesis RWW (Shangzhuang Town, Haidian District, Beijing, China) by marking the chromosomes and microtubules of parthenogenetic RWW oocytes via immunostaining. The immunostaining results show that there is a canonical meiotic spindle formed in the triploid parthenogenetic RWW oocytes, but chromosomes segregate at only one pole, which means that there is a chromosomal unipolar division during the oogenesis of the parthenogenetic RWW. Furthermore, we cloned the conserved sequences of parthenogenetic RWW REC8 and Tws, and designed primers based on the parthenogenetic RWW sequence to detect expression patterns by quantitative PCR (Q-PCR). Q-PCR results indicate that the expression of REC8 and Tws in ovarian tissue of bisexual Drosophila melanogaster is 0.98 and 10,000.00 times parthenogenetic RWW, respectively (p < 0.01). The results show that Tws had low expression in parthenogenetic RWW ovarian tissue, and REC8 was expressed normally. Our study suggests that the chromosomal unipolar division and deletion of Tws may cause parthenogenesis in RWW.

scholarly journals MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation

2012 ◽  
Vol 95 (11) ◽  
pp. 6529-6535 ◽  
Author(s):  
M. Wang ◽  
S. Moisá ◽  
M.J. Khan ◽  
J. Wang ◽  
D. Bu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Expression Patterns ◽  
Microrna Expression ◽  
Bovine Mammary Gland ◽  
Stage Of Lactation

scholarly journals Cardiac remodeling and pre-eclampsia: an overview of microRNA expression patterns

2018 ◽  
Vol 52 (3) ◽  
pp. 310-317 ◽  
Author(s):  
Z. Mohseni ◽  
M. E. A. Spaanderman ◽  
J. Oben ◽  
M. Calore ◽  
E. Derksen ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Expression Patterns ◽  
Microrna Expression

Identification of altered MicroRNA expression patterns in synovial sarcoma

2010 ◽  
Vol 50 (3) ◽  
pp. 137-145 ◽  
Author(s):  
Masanori Hisaoka ◽  
Atsuji Matsuyama ◽  
Yuichi Nagao ◽  
Lan Luan ◽  
Toshihiko Kuroda ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Expression Patterns ◽  
Microrna Expression

scholarly journals MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy

2017 ◽  
Vol 39 (5) ◽  
pp. 533-540 ◽  
Author(s):  
Ivyna Pau Ni Bong ◽  
Ching Ching Ng ◽  
Puteri Baharuddin ◽  
Zubaidah Zakaria
Keyword(s):  
Multiple Myeloma ◽  
Expression Patterns ◽  
Target Prediction ◽  
Microrna Expression

scholarly journals Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Evguenia Nepotchatykh ◽  
Wesam Elremaly ◽  
Iurie Caraus ◽  
Christian Godbout ◽  
Corinne Leveau ◽  
...  
Keyword(s):  
Treatment Options ◽  
Expression Patterns ◽  
Chronic Fatigue ◽  
Microrna Expression ◽  
Myalgic Encephalomyelitis ◽  
Circulating Microrna ◽  
Prevention Measures ◽  
Case Definitions ◽  
Specific Symptom ◽  
Fatigue Syndrome

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.

scholarly journals Mining expression and prognosis of FOLR1 in ovarian cancer by using Oncomine and Kaplan-Meier plotter

Pteridines ◽  
2019 ◽  
Vol 30 (1) ◽  
pp. 158-164
Author(s):  
Qingyuan Su ◽  
Qingyuan Lv ◽  
Ruijin Wu
Keyword(s):  
Ovarian Cancer ◽  
Mrna Expression ◽  
Ovarian Tumor ◽  
Ovarian Tissue ◽  
Progression Free Survival ◽  
Free Survival ◽  
Normal Ovarian Tissue ◽  
Oncomine Database ◽  
Kaplan Meier ◽  
Kaplan Meier Plotter

Abstract Objective: To further explore folate receptor 1 (FOLR1) gene expression in ovarian cancer and its association with patients’ prognosis by deep mining the Oncomine and Kaplan-Meier plotter databases. Methods: FOLR1 mRNA expression data of ovarian cancer were retrieved from the Oncomine database and further analyzed by comparing tumor to healthy tissue. The prognostic value of FOLR1 in ovarian cancer was analyzed by Kaplan-Meier Plotter, an online survival analysis database. Results A total of 439 studies were included in the Oncomine database in multiple types of cancers. Of the 439 studies, there were 54 with statistical differences for the expression of FOLR1, 19 with increased expression of FOLR1 and 35 with decreased expression comparing ovarian cancer to normal ovary tissue. After searching the Oncomine database, six datasets were discovered comparing the mRNA expression in ovarian tumor to healthy tissue. FOLR1 mRNA expression in ovarian tumor was significantly higher than that of normal ovarian tissue (all p<0.05). The Kaplan-Meier Plotter database analyzed the correlation between FOLR1 expression and ovarian cancer patient’s prognosis. A significant difference of progression-free survival between FOLR1 high and low expressing groups was found in ovarian cancer patients (HR=1.14, 95%CI: 1.00-1.29, p=0.043). However, the overall survival was not statistically different between high and low FOLR1 expressing patients (HR=0.95, 95%CI: 0.84-1.09, p=0.48). Conclusion FOLR1 mRNA was found to be highly expressed in ovarian tumor compared to normal ovarian tissue. Elevated FOLR1 mRNA expression was associated with the poor progression-free survival.

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